Universitat de Barcelona
Now showing items 197-216 of 315
Bacterial infections are a major health concern worldwide due to the mortality and comorbidity associated levels. Besides the development of drug-resistance mechanisms, most recalcitrant infections are caused by bacteria ...
Linum album is an herbaceous plant with medical interest due to its content of podophyllotoxin (PTOX), an aryltetralin lignan with cytotoxic activity. The study of biotechnological alternatives has generated big interest. ...
The central topic of this thesis has been the study, development and validation of diverse multiplexed diagnostics platforms and techniques that can be applied to a wide range of topics, from environmental monitoring to ...
Receptor activator of nuclear factor kappa-β ligand (RANKL) and its receptor RANK are key mediators of bone resorption1,2. RANKL, its receptor RANK and its natural decoy receptor OPG, which is a competitive inhibitor that ...
[eng] The present dissertation aims at broadening current knowledge regarding the importance of bodily or tissue status of bioactive compounds that are highly abundant in the Mediterranean diet (carotenoids and polyphenols) ...
The thesis is presented as a compendium of publications and includes six different sections: General Introduction, Objectives, Results, General Discussion, Conclusions and References. The General Introduction summarizes ...
[eng] Plant specialized metabolism is the source of a wide range of bioactive compounds, some of which with relevant pharmacological properties. Nowadays, cancer is one of the main causes of mortality worldwide, therefore, ...
La tuberculosi és una infecció bacteriana causada per un micobacteri anomenat Mycobacterium tuberculosis. Actualment és la primera causa mundial de mortalitat causada per un agent infecciós fins i tot per sobre de la ...
Local invasion is a key cell-biological event in the metastatic cascade. In response to a changing microenvironment, cancer cells may act using two main strategies of invasion: single cell invasion and collective invasion. ...
Quatsomes are lipid-based nanovesicles developed by Nanomol group, composed of ionic surfactants and sterol derivatives. Regarding their properties, Quatsomes have shown to be highly homogenous and stable for years, important ...
Avui en dia, la única solució per a pacients que es troben en una situació de fase terminal de malaltia hepàtica o en una lesió hepàtica aguda es el transplantament. La demanda d’òrgans per a aquesta finalitat supera ...
Las lesiones del músculo esquelético son las lesiones más comunes en el ámbito deportivo (su frecuencia puede variar del 10-55%), siendo una preocupación importante en la medicina deportiva. Más del 90% de todas las lesiones ...
The use of imaging techniques routinely used for diagnosis and the assessment for treatment response in oncology allow us to analyze the changes in body composition that occur during treatment and how these changes impact ...
[eng] Myotonic dystrophy type 1 (DM1), one of the more complex diseases already known, is the most common and multisystemic rare neuromuscular disease among adults, without cure and limited pharmacological treatments. In ...
Three-dimensional ligand-based virtual screening methods have been used for many years in drug discovery, with a variable success depending on different factors, such as the complexity of the target system or the suitability ...
Oncolytic virus (OV)-based therapies have an emerging role in the treatment of solid tumors, involving both direct cell lysis and immunogenic cell death. Nonetheless, tumor- associated stroma limits the efficacy of oncolytic ...
Light-controlled manipulation of neuronal activity has transformed the field of neurobiology. Light provides temporal and spatial resolution over activation or inhibition of targeted populations of neurons, one single ...
Bone is a highly organised and specialised connective tissue that provides a rigid, protective and supporting framework to the body. In addition to this, bone is unique in its capacity to self-regenerate without the ...
L'èxit dels agents biològics pel tractament de la malaltia inflamatòria intestinal es veu reduït pel fet que no tots els pacients responen bé al tractament i està descrit que fins a un 40% dels pacients que responen ...
El agua es esencial para el sostenimiento de la vida en la tierra, por lo tanto, la calidad debe ser controlada para garantizar su uso de forma segura. Los objetivos planteados en esta tesis están orientados a la optimización ...
