Now showing items 235-254 of 315
Jansana Garcia, Sergi (Date of defense: 2019-11-08)
La presente Tesis versa acerca de estudios sintéticos en el campo de los alcaloides Daphniphyllum, una familia de productos naturales con estructuras de un elevado interés sintético debido a su complejidad estructural y ...
Yoldi, Guillermo (Date of defense: 2018-10-23)
The discovery that RANK signaling mediates the protumorigenic role of progesterone in the mammary gland and its association with poor prognosis in breast cancer has opened the possibility of using RANKL inhibitors for ...
Marzal Martí, Berta (Date of defense: 2023-12-18)
[spa] El cáncer de mama es el tumor más frecuentemente diagnosticado en mujeres y entre sus diversos subtipos, en esta tesis, nos centraremos particularmente en el cáncer de mama HER2+. Esta patología se caracteriza por ...
Mateo Campins, Patricia (Date of defense: 2018-10-17)
La present tesi doctoral està enfocada al desenvolupament de noves petites molècules dirigides a diferents dianes del càncer. Els descobriments recents sobre la seqüenciació genòmica del càncer han revelat que molts dels ...
Vidal Limón, Heriberto Rafael (Date of defense: 2017-07-10)
Los cultivos celulares en suspensión representan un excelente herramienta biotecnológica para la producción de compuestos bioactivos empleados en la industria farmacéutica, cosmética y química. Entre éstos, los metabolitos ...
Molina Contreras, María José (Date of defense: 2017-09-18)
El síndrome de huida de la sombra (Shade Avoidance Syndrome, SAS) se refiere al conjunto de respuestas de las plantas desencadenadas por la detección de la disminución de la razón entre luz roja (R) y roja lejana (FR) de ...
Angulo Urarte, Ana (Date of defense: 2017-02-24)
Class IA PI3K (PI3K) functions have been widely investigated over the last two decades. PI3K signalling is located at the crossroads of many cell surface receptors sending signals to coordinate multiple cellular functions ...
Agnelli, Silvia (Date of defense: 2016-12-14)
Current lifestyle with high-energy diets and characterized by sedentary is triggering an alarming growth in obesity. Obesity along with metabolic syndrome- related co-morbidities (i.e. insulin resistance, atherosclerosis, ...
Ho Palma, Ana Cecilia (Date of defense: 2018-07-26)
Se ha observado en nuestro grupo de investigación que tanto las células 3T3L1 como el tejido adiposo blanco in vivo son capaces de liberar, a partir de la glucosa, grandes cantidades de lactato en condiciones aeróbicas y ...
Quifer Rada, Paola (Date of defense: 2017-06-26)
Beer is by far the most widely consumed alcoholic beverage in the world. Moderate alcohol consumption in general has been inversely associated with incident cardiovascular disease in observational studies. However, it has ...
Soria Florido, María Trinidad (Date of defense: 2019-01-11)
Cardiovascular disease remains the first cause of death worldwide. Pharmacological trials and Mendelian randomization studies have failed to unequivocally prove an inverse association between HDL-C levels and the risk of ...
Casas Masnou, Eduard (Date of defense: 2019-11-25)
Gene regulation mechanisms control the level of transcription of each gene into RNA and the combination of expressed genes determines cell identity. Gene regulation is maintained by epigenetic mechanisms including DNA ...
Núñez Álvarez, Yaiza (Date of defense: 2017-07-26)
HDAC11 is the newest member of the histone deacetylase (HDAC) family and one of the less studied. Its expression was described to be enriched in skeletal muscle tissues from the first moment of its discovery, yet now after ...
Arroba Hidalgo, Ester (Date of defense: 2021-02-10)
The human leukocyte antigen-G (HLA-G) is a non-classic MHC class I molecule. It is called “non-classic” because it differs from classic MHC class I molecules due to its very low amount of polymorphism and highly tissue-restricted ...
Vais, Ricardo Silva dos Santos (Date of defense: 2019-12-13)
The γ-‐tubulin ring complex (γTuRC) is required to efficiently generate new microtubules (MT) in a process known as MT nucleation. In mitotic cells, MT nucleation by γTuRC occurs from the centrosome, in vicinity of the ...
Figueiredo, Ana Raquel Martins (Date of defense: 2017-06-09)
Pericytes (PCs) are important regulators of the vascular development promoting vessel growth and stabilization. They have recently emerged as a therapeutic target to promote or inhibit angiogenesis. Therefore, advancing ...
Garcia Carbonell, Ricard (Date of defense: 2017-12-22)
Inflammatory bowel diseases (IBD) are chronic inflammatory processes that affect the gastrointestinal tract. IBD is characterized by an intestinal inflammation and epithelial cell injury leading to a poor psychosocial ...
González Pérez, Laura (Date of defense: 2019-12-12)
The cell cycle is orchestrated by the periodic activation of Cyclin-dependent kinases (CDKs). The enzymatic activity of CDKs depends on their association with cyclins, however, in some cases these kinases can be activated ...
Banjer, Hamsa Jameel (Date of defense: 2018-07-06)
Transportome alterations have been associated with oncogenesis. The loss of human Concentrative Nucleoside Transporter 1 (hCNT1) during carcinogenesis seems to be a relatively common event in tumors and might by itself ...
Segura Bayona, Sandra (Date of defense: 2018-06-22)
Histone deposition during DNA replication, transcription and repair ensures the faithful maintenance of genetic and epigenetic information. The histone H3-H4 chaperone ASF1 participates in both replication dependent and ...