Now showing items 66-85 of 315
Alqahtani, Abdulateef (Date of defense: 2023-10-25)
[eng] In 2001, the initial hypothesis of targeted protein degradation (TPD) was born to announce the launching of a new era of therapeutics development not by inhibiting a component of ubiquitin-proteasome system as small ...
González Díez, Aleix (Date of defense: 2023-07-24)
[eng] G protein-coupled-receptors (GPCRs) are the largest family of membrane proteins and mediate important cellular responses. Metabotropic glutamate receptors (mGlu) belong to the Glutamate family/Class C GPCR. These ...
Miranda Peñarroya, Maria Gemma (Date of defense: 2022-11-28)
[cat] Les teràpies endoscòpiques bariàtriques (TEB) són estratègies prometedores per al tractament de l'obesitat. No obstant això, hi ha una gran variabilitat en la pèrdua de pes i els individus sovint recuperen el pes ...
Cañellas Santos, Mariona (Date of defense: 2022-11-03)
[eng] This industrial Ph.D. thesis aimed to illustrate the presence of the cell-based bioassays throughout the whole life of a drug product and to demonstrate its importance for a complete characterization of a pharmaceutical ...
Sortino, Rosalba (Date of defense: 2023-10-18)
[eng] G protein-coupled receptors (GPCRs) modulate diverse cellular responses to the majority of neurotransmitters and hormones within the human body. They exhibit much structural and functional diversity and are responsive ...
Gomila Juaneda, Alexandre (Date of defense: 2021-09-20)
The main aim of this thesis is setting up and using in vivo screening techniques to identify and characterize new photopharmacological compounds targeting endogenous proteins. In order to achieve that aim, the thesis ...
Bustos Araya, Marta Eduviges (Date of defense: 2023-02-24)
[eng] The interest of this work was to manufacture solid lipid nanoparticles that serve as a vehicle for biomolecules, specifically Chondroitin sulfate and pEGFP plasmid DNA. In the experimental part, the reagents and ...
Caballero Muñoz, Iracema (Date of defense: 2021-03-26)
Pathologies that result in highly modulated intensities in macromolecular crystal structures pose a challenge for structure solution. To address this issue two studies have been performed: a theoretical study of one of ...
Laveriano Santos, Emily Pilar (Date of defense: 2022-11-29)
[eng] The rising of cardiometabolic risk factors like obesity, higher blood pressure, and alteration in the metabolism of lipids and glucose during adolescence increase the risk of type 2 diabetes mellitus and cardiovascular ...
Rodríguez Monforte, Míriam (Date of defense: 2017-03-06)
Las enfermedades cardiometabólicas son la primera causa de muerte a nivel mundial. La prevención primaria de dichas enfermedades es el pilar fundamental para una salud óptima de los adultos, debiendo empezar desde la ...
Camps i Fajol, Cristina (Date of defense: 2022-12-19)
[eng] Cancer is the second leading cause of death globally. The gold standard for cancer has historically been surgery, radiotherapy and chemotherapy. Although the efficacy of chemotherapy has been broadly confirmed, drug ...
Cano Fernández, Amanda (Date of defense: 2018-11-09)
Las enfermedades del sistema nervioso central (SNC) engloban a un conjunto de patologías de elevada gravedad debido a la importancia de este sistema para el organismo. La Epilepsia del Lóbulo Temporal (TLE) y la Enfermedad ...
Banús Mulet, Antònia (Date of defense: 2019-07-16)
Recentment s’han descrit els receptors de dopamina per la seva implicació en càncer i la seva potencial inhibició com a mecanisme antitumoral. Al present treball s’ha ampliat aquesta recerca a la LLA-T, una malaltia amb ...
Lovera Ulecia, Marta (Date of defense: 2023-05-05)
[eng] Cohen syndrome (CS) is an ultra-rare, multi-system, autosomal recessive disorder caused by mutations in the VPS13B gene on chromosome 8q22.2. The most characteristic clinical features of this disorder are microcephaly, ...
Garrido Trigo, Alba (Date of defense: 2023-05-19)
[eng] Crohn’s disease and ulcerative colitis are chronic inflammatory bowel diseases that show perplexing heterogeneity which is poorly understood at a cellular level. We applied single-cell RNA sequencing and CosMxTM ...
Grau Valls, Laura (Date of defense: 2017-07-24)
Aquesta tesis doctoral està enfocada a la investigació de nous agents amb potencial activitat antitumoral, mitjançant la inhibició d'enzims claus per al desenvolupament i la progressió del càncer, com per exemple KRAS. De ...
Zuazo Gaztelu, Iratxe (Date of defense: 2018-11-23)
Tumor progression is a complex conundrum of events that involve not only tumor cells, but also their surrounding microenvironment. Accounting to the natural dependency of tumors on angiogenesis, its therapeutic targeting ...
Ribó-Coll, Margarita (Date of defense: 2022-12-16)
[spa] Las enfermedades cardiovasculares (ECV), representan la principal causa de morbimortalidad en los países desarrollados y su aumento continúa a nivel mundial. Su denominación hace referencia a varias enfermedades de ...
Hurtado Barroso, Sara (Date of defense: 2019-10-28)
La dieta mediterránea, rica en hortalizas y frutas, tiene efectos beneficiosos en la salud debido en parte a su alto contenido en fitoquímicos biológicamente activos, entre ellos los carotenoides y los polifenoles. Las ...
Negrete Sánchez, Elsa N. (Date of defense: 2019-10-11)
Actualmente, el 80% de los injertos hepático proceden de donantes con muerte cerebral. Sin embargo, la muerte cerebral reduce la tolerancia de los injertos hepáticos a la lesión por isquemia/reperfusión y contrarresta los ...