Universitat de Barcelona
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La presente tesis doctoral se divide, de forma general, en dos principales vertientes, una de carácter metodológica y otra de carácter aplicada. La primera de ellas se ha focalizado en la caracterización de la especie ...
[eng] MYC dysregulation is the most common alteration in cancers, driving several cellular processes that cooperatively promote aberrant cell growth and proliferation. Among them, the induction of protein synthesis has ...
En la presente Tesis Doctoral se presenta la descripción y caracterización de un nuevo tipo de vesícula de membrana externa (MV) en bacterias gramnegativas, hallada tanto en cepas ambientales como en cepas patógenas. Para ...
La enfermedad de Alzheimer es la principal causa de demencia. Es una enfermedad neurodegenerativa para la cual no existe tratamiento curativo. La transtiretina (TTR) es una proteína tetramérica conocida por su función ...
INTRODUCCIÓ: Aquesta tesi doctoral està inclosa dins del Pla de Doctorats Industrials de la Generalitat de Catalunya i s’ha realitzat conjuntament entre la Universitat de Barcelona i una empresa veterinària privada: ...
El metilfenidat HCl (MPH) és un fàrmac clàssic per al tractament del TDAH en nens a partir dels 6 anys, quan altres mesures resulten insuficients. Aquest trastorn es manifesta principalment durant la infància i l’adolescència ...
[eng] Pain and inflammation are the most common and recurrent side effects after surgery and, understandably, the patient's most feared, affecting treatment adherence. The present work aims to characterize in vitro, ex ...
[eng] The field of nanomedicine has garnered increasing clinical interest over the past few decades, leading to the approval of numerous products, particularly in oncology. This is due to their ability to encapsulate and ...
Major unsolved diseases such as Cancer, cardiopathies or neurodegenerative disorders are frequently related with the malunction of complex protein networks. These networks are integrated by the interaction of multiple ...
This thesis shows the research carried out on two specific diseases: familial hypercholesterolemia, which is included within the cardiovascular diseases group, and cancer. These diseases are the major cause of deaths in ...
[eng] In 2001, the initial hypothesis of targeted protein degradation (TPD) was born to announce the launching of a new era of therapeutics development not by inhibiting a component of ubiquitin-proteasome system as small ...
[eng] G protein-coupled-receptors (GPCRs) are the largest family of membrane proteins and mediate important cellular responses. Metabotropic glutamate receptors (mGlu) belong to the Glutamate family/Class C GPCR. These ...
[cat] Les teràpies endoscòpiques bariàtriques (TEB) són estratègies prometedores per al tractament de l'obesitat. No obstant això, hi ha una gran variabilitat en la pèrdua de pes i els individus sovint recuperen el pes ...
[eng] This industrial Ph.D. thesis aimed to illustrate the presence of the cell-based bioassays throughout the whole life of a drug product and to demonstrate its importance for a complete characterization of a pharmaceutical ...
[eng] G protein-coupled receptors (GPCRs) modulate diverse cellular responses to the majority of neurotransmitters and hormones within the human body. They exhibit much structural and functional diversity and are responsive ...
The main aim of this thesis is setting up and using in vivo screening techniques to identify and characterize new photopharmacological compounds targeting endogenous proteins. In order to achieve that aim, the thesis ...
[eng] The interest of this work was to manufacture solid lipid nanoparticles that serve as a vehicle for biomolecules, specifically Chondroitin sulfate and pEGFP plasmid DNA. In the experimental part, the reagents and ...
[eng] Lipid metabolism (biosynthesis, storage, and mobilization of lipids within an organism) is a very important aspect of energy homeostasis and plays an essential. Obesity is a complex multifactorial disease characterized ...
Pathologies that result in highly modulated intensities in macromolecular crystal structures pose a challenge for structure solution. To address this issue two studies have been performed: a theoretical study of one of ...
[eng] The rising of cardiometabolic risk factors like obesity, higher blood pressure, and alteration in the metabolism of lipids and glucose during adolescence increase the risk of type 2 diabetes mellitus and cardiovascular ...
