Now showing items 21-40 of 308
Arroyo Solera, Irene (Date of defense: 2017-06-22)
En múltiples tipos tumorales, SERPINA E1 se asocia con una peor evolución clínica de los pacientes. En el carcinoma escamoso de cabeza y cuello (CECC), el aumento del nivel de expresión de SERPINA E1 por parte de las células ...
Quifer Rada, Paola (Date of defense: 2017-06-26)
Beer is by far the most widely consumed alcoholic beverage in the world. Moderate alcohol consumption in general has been inversely associated with incident cardiovascular disease in observational studies. However, it has ...
Petrillo, Giovanna (Date of defense: 2017-06-28)
The rapid progress in structural and molecular biology over the past fifteen years has allowed chemists to access the structures of enzymes, of their complexes and of engineered variants. This wealth of structural information ...
Félez Sánchez-Ocaña, Marta (Date of defense: 2017-06-29)
Papillomaviruses (PVs) are a numerous family of small dsDNA viruses infecting virtually all mammals. PVs cause infections without triggering a strong immune response, and natural infection provides only limited protection ...
Aznar Lou, Ignacio (Date of defense: 2017-06-29)
La no iniciación es un comportamiento que se caracteriza por no empezar aquellos tratamientos farmacológicos prescritos por primera vez. Este comportamiento puede estar influenciado por distintos factores y parámetros ...
Moreno Fortuño, David (Date of defense: 2017-06-30)
Saccharomyces cerevisiae és un model escaient per estudiar el procés d’envelliment a nivell cel.lular gràcies al seu mecanisme de divisió asimètrica. Fent una analogia amb l’envelliment en organismes superiors, on les ...
Pou Cabello, Ana (Date of defense: 2017-06-30)
Over the past decade, sphingolipids have emerged as a new class of modulators of various cell functions. Ceramide, which is the central molecule in the biosynthesis of sphingolipids and glycosphingolipids, is involved in ...
Contreras Muñoz, Paola (Date of defense: 2017-07-07)
Las lesiones del músculo esquelético son las lesiones más comunes en el ámbito deportivo (su frecuencia puede variar del 10-55%), siendo una preocupación importante en la medicina deportiva. Más del 90% de todas las lesiones ...
Hidalgo Martínez, Diego Alberto (Date of defense: 2017-07-10)
The thesis is presented as a compendium of publications and includes six different sections: General Introduction, Objectives, Results, General Discussion, Conclusions and References. The General Introduction summarizes ...
Vidal Limón, Heriberto Rafael (Date of defense: 2017-07-10)
Los cultivos celulares en suspensión representan un excelente herramienta biotecnológica para la producción de compuestos bioactivos empleados en la industria farmacéutica, cosmética y química. Entre éstos, los metabolitos ...
Lozano Mena, David (Date of defense: 2017-07-10)
En la present Tesi Doctoral s’ha desenvolupat una metodologia sintètica per accedir a compostos policíclics complexos funcionalitzats de manera senzilla i eficaç, amb l’objectiu de poder generar a partir d’aquests un alquè ...
Ruiz-Loscertales, H. (Héctor) (Date of defense: 2017-07-17)
Los Sistemas Personalizados de Dosificación (SPD) son un sistema de reacondicionado donde el farmacéutico organiza los medicamentos de forma farmacéutica sólida que toma un determinado paciente durante una semana, siguiendo ...
Limón Magaña, David (Date of defense: 2017-07-21)
anostructured supramolecular hydrogels and gold nanoparticles, as two kinds of nanomaterials, were synthsized, characterized and evaluated for their potential as drug delivery systems. Two bis-imidazolium cationic ...
Grau Valls, Laura (Date of defense: 2017-07-24)
Aquesta tesis doctoral està enfocada a la investigació de nous agents amb potencial activitat antitumoral, mitjançant la inhibició d'enzims claus per al desenvolupament i la progressió del càncer, com per exemple KRAS. De ...
Núñez Álvarez, Yaiza (Date of defense: 2017-07-26)
HDAC11 is the newest member of the histone deacetylase (HDAC) family and one of the less studied. Its expression was described to be enriched in skeletal muscle tissues from the first moment of its discovery, yet now after ...
Leal Witt, María Jesús (Date of defense: 2017-07-27)
INTRODUCCIÓN: La obesidad en uno de los mayores factores de riesgo para desordenes metabólicos y cardiovasculares. El exceso de peso ganado durante la infancia aumenta el riesgo de enfermedad en el adulto, sin embargo ...
Ortiz Hernández, Raül (Date of defense: 2017-09-06)
La regulació local de la síntesi proteica permet a la neurona respondre ràpidament a senyals sinàptiques, és un element fonamental de la plasticitat sinàptica i està alterat en moltes patologies neuronals. La síntesi de ...
Requena Osete, Jordi (Date of defense: 2017-09-08)
Induced pluripotent stem cells (iPSC) can be made from adult somatic cells by reprogramming them with Oct4, Sox2, Klf4 and c-Myc. IPSC have given rise to a new technology to study and treat human disease (Takahashi et al., ...
Moizé Arcone, Violeta (Date of defense: 2017-09-14)
BACKGROUND: Bariatric surgery (BS) is the most effective long-term therapy for the treatment of severe obesity. Benefits of BS include a reduction of overall and cardiovascular mortality, incidence of first occurrence of ...
Calatayud Aristoy, Carles (Date of defense: 2017-09-14)
Despite the advances in the identification of genes and proteins involved in Parkinson’s disease (PD), there are still appreciable gaps in our understanding of the mechanisms underlying the chronic neurodegenerative process ...