Now showing items 148-167 of 315

    Immunoreceptor MerTK: A journey from the membrane into the nucleus of human dendritic cells 

    Borgman, Kyra J. E. (Date of defense: 2018-10-26)

    Discrimination between foreign and potentially harmful antigens, and the body’s own tissue is one of the most crucial first steps that lays at the basis of a proper immune response. Immunoreceptors are cell membrane embedded ...

    The impact of nutrients on clock genes and metabolism: their role for the prevention and treatment of metabolic diseases 

    Castillo Figueroa, Ana Lucía (Date of defense: 2017-04-24)

    A number of recent studies in animals and humans have linked energy regulation and the circadian clock at the molecular, physiological and behavioral levels, concluding that disruption of clock genes results in metabolic ...

    Impacto de los factores de riesgo cardiovascular en las células madre de tejido adiposo 

    Béjar Serrano, María Teresa (Date of defense: 2016-12-19)

    Las enfermedades cardiovasculares se desarrollan como consecuencia de la interacción entre factores genéticos y ambientales. Los factores de riesgo cardiovascular son una serie de condiciones que favorecen la aparición de ...

    Improved Preparative Chemical Methodologies to Address Challenging Targets: Synthetic, Semi-synthetic and Multicomponent Approaches 

    Pedrola Teixell, Marina (Date of defense: 2022-07-14)

    In the context of facilitated methodologies for the obtention of bioactive compounds, in this thesis we have explored the possibility of introducing reliable, pot-economic and semi-synthetic approaches in the quest of ...

    Improving islet-graft revascularization 

    Alves Figueiredo, Hugo Jorge (Date of defense: 2018-06-29)

    El trasplante de islotes ha sido reconocido como una prometedora opción de tratamiento de la diabetes tipo 1 (DT1) tras la introducción del protocolo de Edmonton, el cual enfatiza el requerimiento de un adecuado número de ...

    In silico molecular modelling and design of heme-containing peroxidases for industrial applications 

    Cañellas Fontanilles, Marina (Date of defense: 2018-07-17)

    It is widely known that the development of modern chemistry and the consequent world industrialization have improved our quality of life to unimaginable levels. However, these advances have come with a high cost, causing ...

    Influencia de la educación nutricional, hábitos de estilo de vida obesogénicos y predictores de pérdida de peso en pacientes con obesidad grave incluidos en un programa de cirugía bariatrica 

    Parri Bonet, Alejandra (Date of defense: 2019-11-13)

    INTRODUCCIÓN: La obesidad grave es una enfermedad crónica que se caracteriza por un exceso de grasa corporal, que condiciona un aumento de la morbimortalidad. La cirugía bariátrica es el tratamiento de elección cuando ha ...

    Influencia del tipo de lípidos de la nutrición parenteral sobre la retinopatía de la prematuridad 

    Cabañas Poy, Mª José (Date of defense: 2022-05-12)

    INTRODUCCIÓN. La retinopatía de la prematuridad (Retinopathy of prematurity, ROP) es una vitreorretinopatía proliferativa que afecta a los recién nacidos prematuros y es una de las principales causas de ceguera infantil. ...

    Insight into the structure and function of engineered biocatalysts: serine hydroxymethyltransferase from Streptococcus thermophilus and halohydrine dehalogenase D2 from Gammaproteobacterium 

    Petrillo, Giovanna (Date of defense: 2017-06-28)

    The rapid progress in structural and molecular biology over the past fifteen years has allowed chemists to access the structures of enzymes, of their complexes and of engineered variants. This wealth of structural information ...

    Interactions between marine picoeukaryotes and their viruses one cell at a time = Interacciones entre picoeucariotas marinos y sus virus célula a célula 

    Castillo de la Peña, Yaiza M. (Date of defense: 2019-12-17)

    Marine viruses are key components of marine microbial communities, as they influence the cellular abundances and the community structure of microbes, participate in their genetic exchange, and intervene in the ocean ...

    Interrelación entre la respuesta a sombra y la síntesis de carotenoides en Arabidopsis thaliana 

    Ortiz Alcaide, Miriam (Date of defense: 2017-05-10)

    Los carotenoides son pigmentos fotosintéticos con un papel esencial para la protección de los cloroplastos frente al daño fotooxidativo causado por el exceso de irradiación solar. Cuando las plantas crecen en alta densidad ...

    Intervenciones nutricionales en la prevención cardiovascular y efectos de los factores de riesgo en el tejido adiposo 

    Lambert Goitia, Carmen (Date of defense: 2019-12-19)

    Las enfermedades cardiovasculares son una de las principales causas de mortalidad y morbilidad a nivel mundial, apareciendo como consecuencia de la acumulación de diversos factores de riesgo, tanto genéticos como ambientales. ...

    Intervención educativa en ancianos receptores de un servicio de teleasistencia destinado al incremento de conocimientos sobre alimentación y actividad física y a la reducción del riesgo de inseguridad alimentaria, malnutrición y sedentarismo (ICAAF-RIMAS) 

    Garrido Carrasco, Patricia Elena (Date of defense: 2019-11-27)

    El envejecimiento de la población comporta una mayor necesidad de servicios de cuidado para las personas mayores y la necesidad de tener en cuenta parámetros alimentarios y de actividad física para asegurar una óptima ...

    Into the structure of human full-length Smad proteins and the impact of cancer mutations 

    Gomes, Tiago Lopes (Date of defense: 2019-11-05)

    Signal transduction pathways are essential mechanisms that cells use to perform a myriad of biological processes that when aberrant, can cause serious diseases. Understanding the molecular basis of these pathways in detail ...

    Investigació en biomarcadors de l’estat de la dopamina i la serotonina en pacients neuropediàtrics 

    Batllori Tragant, Marta (Date of defense: 2021-04-12)

    Els errors congènits del metabolisme són malalties d’origen genètic amb una baixa prevalença dins de la població general. Aquestes malalties solen estar causades per mutacions en gens que provoquen un mal funcionament ...

    Investigating early functional alteration in a human iPSC-based model of Parkinson’s Disease 

    Carola, Giulia (Date of defense: 2019-07-26)

    Dopaminergic neurons (DAn) were efficiently differentiated from 6 different iPSC lines derived from a 2 control, 3 PD lines, and an isogenic PD line. We characterize the culture at different time point in order to verify ...

    Investigating Glial Contributions During Parkinson’s Disease Pathogenesis Using Patient-Specific iPSC-Derived Cells 

    di Domenico, Angelique (Date of defense: 2017-12-18)

    La malaltia de Parkinson (PD) s'associa amb la degeneració de les neurones dopaminèrgiques del mesencèfal ventral (vmDA) i l'acumulació d'inclusions citoplasmàtiques, els cossos de Lewy, compostos principalment per la α ...

    Investigating the genetic component of Parkinson’s disease through the use of human induced pluripotent stem cells and gene editing 

    Calatayud Aristoy, Carles (Date of defense: 2017-09-14)

    Despite the advances in the identification of genes and proteins involved in Parkinson’s disease (PD), there are still appreciable gaps in our understanding of the mechanisms underlying the chronic neurodegenerative process ...

    Investigation of branched and linear polymers as oral delivery systems of antimalarial drugs 

    Martí Coma-Cros, Elisabet (Date of defense: 2019-09-27)

    Malaria is an infectious disease that affects nearly half of the population in 90 countries around the world. In 2017 it was estimated that there were 219 million cases and 435,000 deaths disproportionately distributed ...

    Involvement of Polyamines in PAMP-triggered Immunity and Systemic Acquired Resistance (SAR). Extragenic Suppressors of Immune Hybrid Incompatibility 

    Liu, Changxin (Date of defense: 2020-10-29)

    The main topic of this Thesis is to investigate the contribution of polyamines to defense in Arabidopsis thaliana and the requirement of callose deposition for full expression of effector-triggered immunity in autoimmune ...