Now showing items 156-175 of 315

    Insight into the structure and function of engineered biocatalysts: serine hydroxymethyltransferase from Streptococcus thermophilus and halohydrine dehalogenase D2 from Gammaproteobacterium 

    Petrillo, Giovanna (Date of defense: 2017-06-28)

    The rapid progress in structural and molecular biology over the past fifteen years has allowed chemists to access the structures of enzymes, of their complexes and of engineered variants. This wealth of structural information ...

    Interactions between marine picoeukaryotes and their viruses one cell at a time = Interacciones entre picoeucariotas marinos y sus virus célula a célula 

    Castillo de la Peña, Yaiza M. (Date of defense: 2019-12-17)

    Marine viruses are key components of marine microbial communities, as they influence the cellular abundances and the community structure of microbes, participate in their genetic exchange, and intervene in the ocean ...

    Interrelación entre la respuesta a sombra y la síntesis de carotenoides en Arabidopsis thaliana 

    Ortiz Alcaide, Miriam (Date of defense: 2017-05-10)

    Los carotenoides son pigmentos fotosintéticos con un papel esencial para la protección de los cloroplastos frente al daño fotooxidativo causado por el exceso de irradiación solar. Cuando las plantas crecen en alta densidad ...

    Intervenciones nutricionales en la prevención cardiovascular y efectos de los factores de riesgo en el tejido adiposo 

    Lambert Goitia, Carmen (Date of defense: 2019-12-19)

    Las enfermedades cardiovasculares son una de las principales causas de mortalidad y morbilidad a nivel mundial, apareciendo como consecuencia de la acumulación de diversos factores de riesgo, tanto genéticos como ambientales. ...

    Intervención educativa en ancianos receptores de un servicio de teleasistencia destinado al incremento de conocimientos sobre alimentación y actividad física y a la reducción del riesgo de inseguridad alimentaria, malnutrición y sedentarismo (ICAAF-RIMAS) 

    Garrido Carrasco, Patricia Elena (Date of defense: 2019-11-27)

    El envejecimiento de la población comporta una mayor necesidad de servicios de cuidado para las personas mayores y la necesidad de tener en cuenta parámetros alimentarios y de actividad física para asegurar una óptima ...

    Into the structure of human full-length Smad proteins and the impact of cancer mutations 

    Gomes, Tiago Lopes (Date of defense: 2019-11-05)

    Signal transduction pathways are essential mechanisms that cells use to perform a myriad of biological processes that when aberrant, can cause serious diseases. Understanding the molecular basis of these pathways in detail ...

    Investigació en biomarcadors de l’estat de la dopamina i la serotonina en pacients neuropediàtrics 

    Batllori Tragant, Marta (Date of defense: 2021-04-12)

    Els errors congènits del metabolisme són malalties d’origen genètic amb una baixa prevalença dins de la població general. Aquestes malalties solen estar causades per mutacions en gens que provoquen un mal funcionament ...

    Investigating early functional alteration in a human iPSC-based model of Parkinson’s Disease 

    Carola, Giulia (Date of defense: 2019-07-26)

    Dopaminergic neurons (DAn) were efficiently differentiated from 6 different iPSC lines derived from a 2 control, 3 PD lines, and an isogenic PD line. We characterize the culture at different time point in order to verify ...

    Investigating Glial Contributions During Parkinson’s Disease Pathogenesis Using Patient-Specific iPSC-Derived Cells 

    di Domenico, Angelique (Date of defense: 2017-12-18)

    La malaltia de Parkinson (PD) s'associa amb la degeneració de les neurones dopaminèrgiques del mesencèfal ventral (vmDA) i l'acumulació d'inclusions citoplasmàtiques, els cossos de Lewy, compostos principalment per la α ...

    Investigating the genetic component of Parkinson’s disease through the use of human induced pluripotent stem cells and gene editing 

    Calatayud Aristoy, Carles (Date of defense: 2017-09-14)

    Despite the advances in the identification of genes and proteins involved in Parkinson’s disease (PD), there are still appreciable gaps in our understanding of the mechanisms underlying the chronic neurodegenerative process ...

    Investigation of branched and linear polymers as oral delivery systems of antimalarial drugs 

    Martí Coma-Cros, Elisabet (Date of defense: 2019-09-27)

    Malaria is an infectious disease that affects nearly half of the population in 90 countries around the world. In 2017 it was estimated that there were 219 million cases and 435,000 deaths disproportionately distributed ...

    Involvement of Polyamines in PAMP-triggered Immunity and Systemic Acquired Resistance (SAR). Extragenic Suppressors of Immune Hybrid Incompatibility 

    Liu, Changxin (Date of defense: 2020-10-29)

    The main topic of this Thesis is to investigate the contribution of polyamines to defense in Arabidopsis thaliana and the requirement of callose deposition for full expression of effector-triggered immunity in autoimmune ...

    Involvement of Polyamines in Ribosome Biogenesis and Identification of Potential Genes Associated with Spermine Resistance in Arabidopsis thaliana 

    Murillo Villuendas, Ester (Date of defense: 2023-10-20)

    [eng] Polyamines are small polycationic molecules that contain amino groups and are found in all living organisms. This study is aimed at acquiring a comprehensive understanding of the diverse roles of polyamines in plants, ...

    IRBC-induced p53-dependent Cell Death in c-MYC-driven tumors mediated by loss of MCL1 

    Domostegui Fernández, Ana (Date of defense: 2019-12-05)

    The oncogene MYC is altered and its expression is deregulated in up to 70% of human cancers, including B cell neoplasms. Earlier studies in a mouse model of Eμ-MYC-driven B-cell lymphomas reported that oncogenic MYC relies ...

    LIF as a metabolic messenger: study of glucose sensing by NSCLC and LIF-mediated nutrient stress responses 

    Hernández Madrigal, Miguel (Date of defense: 2022-06-17)

    Tumours grow in a self-imposed hypoglycaemic microenvironment due to their exacerbated metabolic needs. To thrive in these harsh conditions, malignant cells must adapt their own metabolic routes and hijack the host nutrient ...

    Los sistemas personalizados de dosificación y su aportación a la seguridad de los pacientes 

    Ruiz-Loscertales, H. (Héctor) (Date of defense: 2017-07-17)

    Los Sistemas Personalizados de Dosificación (SPD) son un sistema de reacondicionado donde el farmacéutico organiza los medicamentos de forma farmacéutica sólida que toma un determinado paciente durante una semana, siguiendo ...

    Mapping protein aggregation by deep mutational scanning 

    Seuma Areñas, Mireia (Date of defense: 2023-01-18)

    [eng] Proteins can adopt multiple conformations and material states, from soluble states to self- assemblies, such as liquid condensates or amyloids. Protein aggregation has been associated with many human diseases but how ...

    Marcadors genètics d'eficàcia i toxicitat en el tractament del càncer colorectal 

    Riera Armengol, Pau (Date of defense: 2020-09-23)

    El càncer colorectal (CCR) és una neoplàsia molt freqüent que causa una elevada mortalitat arreu del món. Els fàrmacs més utilitzats en el seu maneig són quimioteràpics (fluoropirimidines, oxaliplatí i irinotecan), agents ...

    Mecanismos de neuroprotección mediante la modulación de SIRT1 

    Corpas Expósito, Rubén (Date of defense: 2016-12-22)

    El aumento de la esperanza de vida poblacional que ha tenido lugar en las últimas décadas, previsiblemente conducirá a un incremento de la incidencia de enfermedades asociadas con la edad, incluyendo la demencia. La principal ...

    Mecanismos de remodelado y calcificación cardiovascular: papel del receptor nuclear NOR-1 y la LOX 

    Ballester Servera, Carme (Date of defense: 2023-10-16)

    [spa] La calcificación cardiovascular (CCV) afecta a arterias y válvulas comprometiendo su normal funcionamiento y aumentando el riesgo de sufrir accidentes cardiovasculares y de desarrollar hipertrofia cardíaca e insuficiencia ...