Universitat de Barcelona
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[eng] Nuclear receptors (NRs) are a superfamily of ligand-activated transcription factors that function as biological sensors to regulate gene expression in a timeand tissue-specific and manner. The coordinated actions ...
La viroterapia oncolítica es un tratamiento emergente basado en el uso de virus replicativos que de manera selectiva infectan células tumorales y provocan su muerte. Hasta la fecha, se han producido grandes avances en dotar ...
Induced pluripotent stem cells (iPSC) can be made from adult somatic cells by reprogramming them with Oct4, Sox2, Klf4 and c-Myc. IPSC have given rise to a new technology to study and treat human disease (Takahashi et al., ...
Los grandes ensamblados macromoleculares presentan unas propiedades mecánicas extraordinarias las cuales los hacen perfectos para su uso con fines muy distintos dentro de la nanotecnología y la biomedicina. El virus diminuto ...
La acuicultura es una importante actividad económica vinculada a la producción de alimentos que se encuentra en etapa de expansión. Sin embargo, la producción de especies carnívoras como la dorada (Sparus aurata) presenta ...
The study of the 3D structural details of protein interactions is essential to understand biomolecular functions at the molecular level. In this context, the limited availability of experimental structures of protein-protein ...
[eng] L-type amino acid transporters play key roles in human physiology and are involved in several human pathologies such as primary inherited aminoacidurias (Feliubadaló et al., 1999; Torrents et al., 1999), autism ...
Infectious diseases are still one of the main leading causes of death worldwide mainly due the overuse and the lack of development of new antibiotics. This fact has increased the appearance of multidrug resistance (MDR) ...
Once a target is identified and characterized, the long pathway to develop a drug starts. In this process, biophysical methods have an important part to play and nowadays are firmly combined at several stages. In this ...
Rosmarinic acid (RA), an ester of caffeic acid and 3,4-dihydroxyphenyl lactic acid, is widely distributed in the plant kingdom, including Satureja khuzistanica, a threatened Iranian plant species. Interest in RA is growing ...
The general goal of this thesis has been to progress oncolytic adenovirus therapy for PDAC, by the incorporation of novel preclinical models to test for patient-specific responses and the generation of oncolytic adenoviruses ...
El rabdomiosarcoma (RMS) és el sarcoma de parts toves més comú en nens i adolescents que representa un 3-4 % dels càncers infantils. En canvi, és molt menys freqüent en adults. Principalment consisteix en dues variants ...
Tribbles (TRIB) homologues proteins are a family of three pseudokinases withan important role in controlling immunity, metabolism, and cancer throughprotein-protein interactions (PPIs). TRIB pseudokinases have the same ...
Polyglutamine (polyQ) tracts are low sequence complexity regions frequently found in transcription factors. Abnormal expansions of polyQ tracts in nine different proteins cause a family of neurodegenerative disorders called ...
As innate immune cells, macrophages sense endogenous and exogenous danger signals and respond orchestrating inflammatory processes. For the rapid induction and efficient resolution of inflammatory responses, macrophages ...
[eng] The vault particle, with a mass of 10 MDa and dimensions of 70 nm x 40 nm x 40 nm, is the largest ribonucleoprotein described in the eukaryotic kingdom. The vault shell is organized in two identical moieties, each ...
La presente tesis doctoral se divide, de forma general, en dos principales vertientes, una de carácter metodológica y otra de carácter aplicada. La primera de ellas se ha focalizado en la caracterización de la especie ...
[eng] MYC dysregulation is the most common alteration in cancers, driving several cellular processes that cooperatively promote aberrant cell growth and proliferation. Among them, the induction of protein synthesis has ...
En la presente Tesis Doctoral se presenta la descripción y caracterización de un nuevo tipo de vesícula de membrana externa (MV) en bacterias gramnegativas, hallada tanto en cepas ambientales como en cepas patógenas. Para ...
Major unsolved diseases such as Cancer, cardiopathies or neurodegenerative disorders are frequently related with the malunction of complex protein networks. These networks are integrated by the interaction of multiple ...
