Gomila Juaneda, Alexandre (Date of defense: 2021-09-20)
The main aim of this thesis is setting up and using in vivo screening techniques to identify and characterize new photopharmacological compounds targeting endogenous proteins. In order to achieve ...
Medina Bernal, Ana del Rocío (Date of defense: 2021-11-19)
Determining and understanding protein structure in atomic detail is a fundamental process to the advancement of biotechnology and biomedicine, shedding light the role of macromolecules and their complexes, ...
Pitsili, Eugenia (Date of defense: 2021-11-04)
Metacaspases are a family of cysteine proteases found in lower eukaryotes and plants. They are considered to be distant relatives of caspases, present only in animals. The role of metacaspases is quite ...
Maric, Aida (Date of defense: 2021-11-05)
The circadian clock is an endogenously generated timekeeping mechanism that generates 24-hour rhythms in multiple biological processes. The rhythmic oscillations provide an adaptive advantage, allowing ...
Caballero Muñoz, Iracema (Date of defense: 2021-03-26)
Pathologies that result in highly modulated intensities in macromolecular crystal structures pose a challenge for structure solution. To address this issue two studies have been performed: a theoretical ...
Quintairos Domenech, Luis (Date of defense: 2021-07-08)
Despite advances in immunosuppression, allograft rejection and clinical outcomes remain a challenge in solid organ transplantation. Currently, the immunosuppressive treatment’s individual adjustment is ...
Calatayud Robert, Sara (Date of defense: 2021-12-20)
Proteins are composed of domains, a well-defined region within a protein that constitutes a stable, independently folding, compact structural unit, and that usually performs a specific function. During ...
López Yerena, Anallely (Date of defense: 2021-09-28)
The health promoting attributes associated with following a traditional Mediterranean diet have been reviewed extensively. The principal source of dietary fat in the Mediterranean diet is Extra virgin ...
Baelo Álvarez, Aida (Date of defense: 2021-01-28)
Bacterial infections are a major health concern worldwide due to the mortality and comorbidity associated levels. Besides the development of drug-resistance mechanisms, most recalcitrant infections are ...
Gordaliza Alaguero, Isabel (Date of defense: 2021-11-29)
Mitofusins (MFN1/2) have been demonstrated to play a role in several mitochondrial functions such as mitochondrial dynamics and bioenergetics, interorganelle communication, immune response, autophagy, ...