Topal, Busra (Date of defense: 2020-01-08)
Polyglutamine (polyQ) tracts are low sequence complexity regions frequently found in transcription factors. Abnormal expansions of polyQ tracts in nine different proteins cause a family of neurodegenerative ...
Riaño Canalias, Ferran (Date of defense: 2017-09-29)
Ribosome biogenesis is one of the most energy consuming anabolic processes in a cell, required for the generation of the translational machinery to grow and proliferate. Moreover, this process necessitates ...
Rodríguez Monforte, Míriam (Date of defense: 2017-03-06)
Las enfermedades cardiometabólicas son la primera causa de muerte a nivel mundial. La prevención primaria de dichas enfermedades es el pilar fundamental para una salud óptima de los adultos, debiendo ...
Soria Florido, María Trinidad (Date of defense: 2019-01-11)
Cardiovascular disease remains the first cause of death worldwide. Pharmacological trials and Mendelian randomization studies have failed to unequivocally prove an inverse association between HDL-C ...
Vais, Ricardo Silva dos Santos (Date of defense: 2019-12-13)
The γ-‐tubulin ring complex (γTuRC) is required to efficiently generate new microtubules (MT) in a process known as MT nucleation. In mitotic cells, MT nucleation by γTuRC occurs from the centrosome, ...
Talló Domínguez, Kirian (Date of defense: 2021-06-17)
Lipids are essential components in most living organisms whose functionality varies with their chemical structure. In an aqueous environment, diluted dispersions of phospholipids tend to form vesicles ...
Castillo Figueroa, Ana Lucía (Date of defense: 2017-04-24)
A number of recent studies in animals and humans have linked energy regulation and the circadian clock at the molecular, physiological and behavioral levels, concluding that disruption of clock genes ...
Creus i Cuadros, Anna (Date of defense: 2018-02-27)
The World Health Organization (WHO) 1 says that CVDs are number one cause of death globally. An estimated 17.7 million people died from CVDs in 2015, representing 31% of all global deaths. Over three ...
Gutierrez Prat, Núria (Date of defense: 2018-10-03)
Cells often need to respond to damaging internal and external stimuli. One of the pathways that is frequently activated by stress stimuli involves activation of the kinase p38alpha, which can phosphorylate ...
Palau de Miguel, Anna (Date of defense: 2016-11-30)
Polycomb proteins are important epigenetic regulators involved in the maintenance of stemness and differentiation. In this thesis, I focused on the role of some Polycomb Repressive Complex 1 (PRC1) ...