Facultat de Farmàcia i Ciències de l'Alimentació: Recent submissions
Now showing items 181-200 of 331
Active Liquid Crystals in Confinement
Living systems flow. What appears obvious from our daily observation of people, birds or insects remains surprisingly true at the smallest scale of life. Even at the earliest stages of embryonic development, the most ...
Structural insights into “acid blobs and negative noodles” – The androgen receptor as a case study
Androgen receptor is a transcription factor that plays a key role in prostate cancer development and progression. Its N-terminal intrinsically disordered activation domain is an example of ill- structured negatively charged ...
Intervenciones nutricionales en la prevención cardiovascular y efectos de los factores de riesgo en el tejido adiposo
Las enfermedades cardiovasculares son una de las principales causas de mortalidad y morbilidad a nivel mundial, apareciendo como consecuencia de la acumulación de diversos factores de riesgo, tanto genéticos como ambientales. ...
Computational Study of the Structure and Dynamics of Androgen Receptor Polyglutamine Tract
Polyglutamine (polyQ) tracts are low sequence complexity regions frequently found in transcription factors. Abnormal expansions of polyQ tracts in nine different proteins cause a family of neurodegenerative disorders called ...
Optical control of endogenous receptors and cellular excitability with light
Light-controlled manipulation of neuronal activity has transformed the field of neurobiology. Light provides temporal and spatial resolution over activation or inhibition of targeted populations of neurons, one single ...
Estudi del paper de les proteïnes JNK en el desenvolupament de trastorns metabòlics i cognitius = Study on the role of the JNK proteins in the development of metabolic and cognitive disruptions
Molts estudis previs sobre el paper de les cinases c-JUN N-terminal (JNK) no tenien en compte les diferències existents en l’activitat de cadascuna de les isoformes. Això va provocar que les propostes terapèutiques que ...
The Role of Microtubule nucleation during neural development
The γ-‐tubulin ring complex (γTuRC) is required to efficiently generate new microtubules (MT) in a process known as MT nucleation. In mitotic cells, MT nucleation by γTuRC occurs from the centrosome, in vicinity of the ...
Signal Transduction proteins in Streptococcus pneumoniae and Vibrio cholerae
The aim of this project is to structurally characterize proteins involved in bacterial signal transduction systems by applying X-ray crystallography. Bacteria use signal transduction systems to react in response to any ...
Caracterització morfològica i molecular i estudi epidemiològic d’espècies d’Anisakis i Hysterothylacium (Nematoda: Ascaridoidea) en peixos de consum habitual procedents de l’Atlàntic Nord-Est i del Mediterrani
Aquest treball engloba l’estudi d’espècies de nematodes ascaridoïdeus de les famílies Anisakidae i Raphidascarididae paràsites de peixos marins arreu del món que presenten un interès sanitari i/o comercial. Dins la família ...
Interactions between marine picoeukaryotes and their viruses one cell at a time = Interacciones entre picoeucariotas marinos y sus virus célula a célula
Marine viruses are key components of marine microbial communities, as they influence the cellular abundances and the community structure of microbes, participate in their genetic exchange, and intervene in the ocean ...
A role for heterochromatin and repetitive elements in epigenetic inheritance
Gene regulation mechanisms control the level of transcription of each gene into RNA and the combination of expressed genes determines cell identity. Gene regulation is maintained by epigenetic mechanisms including DNA ...
The supramolecular organization of cancer metabolism: From macromolecular crowding to metabolic reprogramming underlying cancer metastasis and drug resistance
Metastasis and drug resistance represent the two main causes of therapeutic failure in oncology. In the present dissertation, the interplay between them has been interrogated using metabolomics, systems biology and biophysical ...
IRBC-induced p53-dependent Cell Death in c-MYC-driven tumors mediated by loss of MCL1
The oncogene MYC is altered and its expression is deregulated in up to 70% of human cancers, including B cell neoplasms. Earlier studies in a mouse model of Eμ-MYC-driven B-cell lymphomas reported that oncogenic MYC relies ...
Design and synthesis of engineered peptides to target undruggable PPIs: from in silico to in vitro studies
Major unsolved diseases such as Cancer, cardiopathies or neurodegenerative disorders are frequently related with the malunction of complex protein networks. These networks are integrated by the interaction of multiple ...
Intervención educativa en ancianos receptores de un servicio de teleasistencia destinado al incremento de conocimientos sobre alimentación y actividad física y a la reducción del riesgo de inseguridad alimentaria, malnutrición y sedentarismo (ICAAF-RIMAS)
El envejecimiento de la población comporta una mayor necesidad de servicios de cuidado para las personas mayores y la necesidad de tener en cuenta parámetros alimentarios y de actividad física para asegurar una óptima ...
Biotechnological production of rosmarinic acid and ruscogenins. Scaling up the optimized processes to benchtop bioreactors
Rosmarinic acid (RA), an ester of caffeic acid and 3,4-dihydroxyphenyl lactic acid, is widely distributed in the plant kingdom, including Satureja khuzistanica, a threatened Iranian plant species. Interest in RA is growing ...
Química radicalaria aplicada a la síntesis de alcaloides Daphniphyllum
La presente Tesis versa acerca de estudios sintéticos en el campo de los alcaloides Daphniphyllum, una familia de productos naturales con estructuras de un elevado interés sintético debido a su complejidad estructural y ...
Aplicacions de l’enginyeria cristal·lina al descobriment i estudi de noves formes sòlides de principis actius
Aquesta tesi descriu el disseny, optimització i implementació de metodologies d’screening versàtils per a la recerca de noves formes sòlides de compostos orgànics. La certesa d’estar desenvolupant la forma sòlida d’un ...
Influencia de la educación nutricional, hábitos de estilo de vida obesogénicos y predictores de pérdida de peso en pacientes con obesidad grave incluidos en un programa de cirugía bariatrica
INTRODUCCIÓN: La obesidad grave es una enfermedad crónica que se caracteriza por un exceso de grasa corporal, que condiciona un aumento de la morbimortalidad. La cirugía bariátrica es el tratamiento de elección cuando ha ...
Unveiling the biological role of stigmasterol biosynthesis in tomato plants
In plants, the sterol biosynthetic pathway leads to the production of a complex mixture of end-products, among which β-sitosterol, stigmasterol, campesterol, and cholesterol are the most abundant ones. Stigmasterol, the ...
