Facultat de Farmàcia i Ciències de l'Alimentació: Recent submissions
Now showing items 81-100 of 331
Desarrollo y optimización de parches transdérmicos tipo "Drug in Adhesive" de ropinirol de base acrílica mediante un dispositivo laminador de vertido sobre molde (Mold-Casting) diseñado en 3D
[spa] En esta tesis doctoral se realizan el desarrollo, estudio y optimización de parches transdérmicos de base acrílica de tipo "drug in adhesive" de ropinirol para su aplicación tópica en el tratamiento de la enfermedad ...
Identifying new targets to inhibit brat tumour growth in Drosophila melanogaster through combined transcriptomics and functional genome-wide analysis
[eng] I have used the brain tumours that originate in Drosophila larvae upon depletion of the brain tumor (brat) gene as a model to study neoplastic malignant growth. I have used genetic analysis to interrogate the Drosophila ...
Proteína inmunodominante P116 del patógeno humano Mycoplasma pneumoniae: un recipiente para el colesterol y otros lípidos esenciales
[spa] Mycoplasma pneumoniaees una bacteria patógena humana sin pared celular que causa neumonías atípicas y otras infecciones respiratorias. Es una de las pocas especies de procariotas que necesitan lípidos en la integridad ...
New insights into the association between carotenoids, polyphenols and vitamin A, and highly prevalent diseases
[eng] The present dissertation aims at broadening current knowledge regarding the importance of bodily or tissue status of bioactive compounds that are highly abundant in the Mediterranean diet (carotenoids and polyphenols) ...
Metabolic vulnerabilities of rhabdomyosarcoma: insights into the role of ASS1
[eng] Rhabdomyosarcoma (RMS) is the most prevalent soft tissue sarcoma (STS) in children and adolescents. The Alveolar subtype (ARMS) is driven by PAX3-FOXO1, a fusion protein originated from a chromosomal translocation. ...
Efecto “HALO” de una intervención de pérdida de peso mediante cambios en el estilo de vida en familiares de individuos con sobrepeso y/u obesidad. Validación de un cuestionario de adherencia a Dieta Mediterránea hipocalórica
[spa] La obesidad es una enfermedad crónica y un problema de salud pública, producido por un desequilibrio entre la ingesta y el gasto de energía. La prevalencia de la obesidad en todo el mundo se ha duplicado desde 1980, ...
Design and characterization of topical ketorolac tromethamine formulations
[eng] Pain and inflammation are the most common and recurrent side effects after surgery and, understandably, the patient's most feared, affecting treatment adherence. The present work aims to characterize in vitro, ex ...
Synthetic approaches towards organic products of pharmaceutical interest
[eng] The present thesis focuses on the study and synthesis of three active principles (APIs) with therapeutic activity. Although these compounds are commercially available, their route of synthesis are very old, therefore ...
Characterization of the proteome and palmitoylome alterations induced by palmitic and oleic acids in OSCC cells
El papel que juega el metabolismo lipídico en la progresión del cáncer está siendo revisado. Estudios recientes de nuestro laboratorio demuestran que el tratamiento con ácido palmítico (AP) de células en cultivo o ...
Biomarkers and therapeutic targets based on bacterial “Quorum Sensing” system
Infectious diseases are still one of the main leading causes of death worldwide mainly due the overuse and the lack of development of new antibiotics. This fact has increased the appearance of multidrug resistance (MDR) ...
Data integration in inflammatory bowel disease
INTRODUCTION: Inflammatory bowel disease is a complex intestinal disease with several genetic and environmental factors that can influence its course. The ethiology and pathophysiology of the disease is not fully understood. ...
Structure-based drug design of novel antiviral compounds against human herpesvirus and coronavirus
The herpesvirus diseases are increasing in importance as a public health problem throughout the world. Members of the human herpesvirus family are global in distribution and infect 60-95% of the world's population, both ...
Computational and biophysical approaches for the discovery of Tribbles pseudokinases modulators
Tribbles (TRIB) homologues proteins are a family of three pseudokinases withan important role in controlling immunity, metabolism, and cancer throughprotein-protein interactions (PPIs). TRIB pseudokinases have the same ...
Photoswitchable ligands targeting beta-adrenoceptors for in vitro, in vivo and structural studies
G protein-coupled receptors (GPCRs) are a large family of membrane proteins responsible for signaling transduction processes. Due to their roles in modulating essential physiological functions, GPCRs are classical ...
Epigenetic Dysregulation of Monocytes as a Sensor of Activity and Progression in Arthritis
OBJECTIVE: Identifying predictive biomarkers at early stages of undifferentiated arthritis (UA) is crucial for starting appropriate therapies to avoid poor outcomes. Monocytes and macrophages, largely associated with ...
LIF as a metabolic messenger: study of glucose sensing by NSCLC and LIF-mediated nutrient stress responses
Tumours grow in a self-imposed hypoglycaemic microenvironment due to their exacerbated metabolic needs. To thrive in these harsh conditions, malignant cells must adapt their own metabolic routes and hijack the host nutrient ...
Influencia del tipo de lípidos de la nutrición parenteral sobre la retinopatía de la prematuridad
INTRODUCCIÓN. La retinopatía de la prematuridad (Retinopathy of prematurity, ROP) es una vitreorretinopatía proliferativa que afecta a los recién nacidos prematuros y es una de las principales causas de ceguera infantil. ...
Procesamiento de los receptores TAM en patología humana y su empleo como biomarcadores
La familia TAM consta de tres receptores de membrana de tipo tirosina-quinasa: TYRO3, AXL, MERTK. Sus ligandos son Growth Arrest-Specific 6 (GAS6) y la Proteína S (PROS1). Éstas últimas son proteínas dependientes de vitamina ...
Nutritional and body composition changes affecting head and neck cancer patients during oncological treatment
The use of imaging techniques routinely used for diagnosis and the assessment for treatment response in oncology allow us to analyze the changes in body composition that occur during treatment and how these changes impact ...
Improved Preparative Chemical Methodologies to Address Challenging Targets: Synthetic, Semi-synthetic and Multicomponent Approaches
In the context of facilitated methodologies for the obtention of bioactive compounds, in this thesis we have explored the possibility of introducing reliable, pot-economic and semi-synthetic approaches in the quest of ...
