Universitat de Barcelona
Now showing items 21-40 of 75
[eng] Microscopy and Chromosome Conformation Capture (3C) are the two main techniques for studying the three-dimensional (3D) organization of the genome. Microscopy, allowing the visualization of genomic loci in individual ...
Long non-coding RNAs (lncRNAs) are defined as transcripts longer than 200 nucleotides that lack protein-coding potential. Although multiple examples of functional lncRNAs have been described, particularly regulating gene ...
The application of NGS techniques to the study of mature B-cell neoplasms at the research level is providing a large amount of new information, in certain cases with clinical implications, which includes the identification ...
During early development of bilaterian animals, specific body structures are formed and body axes are established. The establishment of body axes requires the precise and coordinated function of signalling pathways and ...
The chloride channel ClCN2 is expressed in glia in the mature nervous system of vertebrates and some physiological functions have been proposed. In addition, human patients with mutations in the gene or dysfunction of the ...
Aromatase inhibitors (AI) are one of the main therapies to treat estrogen-receptor positive breast cancer. AI use is associated with several side effects that affects patient’s quality of life and reduces treatment adherence. ...
El establecimiento de conexiones sinápticas específicas entre neuronas es esencial para la formación de los circuitos neuronales. En muchos sistemas esto requiere de una extensión hacia una capa sináptica concreta y la ...
Las proteínas codificadas por los genes del grupo Polycomb (PcG) constituyen un sistema clave de silenciamiento epigenético. Actúan en forma de complejos multiproteicos y modulan el estado de la cromatina mediante ...
[eng] During the last decade, advances in high-throughput sequencing (HTS) technologies have increased exponentially the generation of genomic data, especially of non-model species. In this thesis, we generated and used ...
In the present work, we studied the evolution of alternative splicing (AS) from different perspectives. First, we performed a preliminary analysis where we identified alternative exons with tissue-specific regulation in ...
The transcription factor NR2E3 participates in photoreceptor cell fate determination as it functions as both transcriptional repressor of cone genes and activator of rod genes. Mutations in NR2E3 cause retinitis pigmentosa ...
Osteoporosis is a general skeletal disorder. It is characterized by a low bone mass and a microarchitectural deterioration of bone tissue, which increase bone fragility and susceptibility to fracture. LRP5 is a widely ...
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental, complex and highly heritable disorder characterised by age-inappropriate symptoms of inattention, impulsivity and hyperactivity that impair the daily ...
Cerebrovascular disease is the leading cause of disability in adults. Independent of clinical variables such as infarct size and location, stroke subtype, and vascular risk factors, individuals have disparate responses ...
The broad objectives of this work are the identification of genes that contribute to the susceptibility to attention-deficit/hyperactivity disorder (ADHD) and cocaine dependence, two disorders that co-occur in patients. ...
La cocaïna és una droga psicoestimulant que actua directament sobre sistema de recompensa del cervell tot produint sensació de plaer. A més, els seus efectes sobre altres àrees cerebrals produeixen alteracions en l’estat ...
Aquesta Tesi té com a objectiu principal contribuir a l’estudi i a la identificació de factors genètics i epigenètics de susceptibilitat a les addiccions i a trastorns comòrbids, tant en humans com en models animals. Els ...
Los artrópodos, durante su historia evolutiva, han colonizado múltiples y diversos hábitats, incluyendo eventos de terrestrialización independientes en los distintos subfilos, e implicando en algunas ocasiones radiaciones ...
[eng] Losses to plant pathogens pose a major threat to global agriculture and food security worldwide. In the context of globalisation and climate change, the emergence and dispersion of pathogens resistant to conventional ...
Osteoporosis is a complex disease, determined by genetic and environmental factors, characterized by a low bone mass and microarchitectural deterioration of bone tissue, with a consequent decrease of bone strength and ...
