Now showing items 258-277 of 304

    Rol de las proteínas α- y γ-sinucleína en la neurotransmisión dopaminérgica nigroestriatal y mesocortical: Implicación en enfermedades neurodegenerativas y trastornos neuropsiquiátricos 

    Pavia Collado, Rubén (Date of defense: 2020-11-06)

    [spa] Las sinucleínas son una familia de proteínas pequeñas y altamente conservadas en vertebrados, especialmente abundantes en las neuronas y típicamente enriquecidas en los terminales presinápticos, donde participan en ...

    Role of intra-abdominal hypertension in the development and outcome of ovarian hyperstimulation syndrome 

    Petrenko, Aleksei (Date of defense: 2022-09-21)

    [spa] INTRODUCCIÓN: El síndrome de hiperestimulación ovárica (SHO) es la complicación yatrogénica más grave y potencialmente mortal asociada con las técnicas de reproducción asistida (TRA). El SHO moderado o grave puede ...

    Role of the NADPH oxidase NOX4 in hepatocyte proliferation 

    Herranz Itúrbide, Macarena (Date of defense: 2021-09-23)

    [spa] La familia de las NADPH oxidasas ha emergido en los últimos años como una importante fuente de producción de radicales libres de oxígeno (ROS), los cuáles juegan un papel fundamental en situaciones fisiológicas y ...

    Role of ZEB factors in B cell activation and malignant progression 

    Profitós Pelejà, Núria (Date of defense: 2020-07-29)

    ZEB1 and ZEB2 are two transcription factors best known for their role driving a dedifferentiation process, commonly referred as epithelial to mesenchymal transition (EMT). This process is carried out either in multiple ...

    Role of ZEB factors in macrophages in atherosclerosis and ovarian cancer 

    Martínez Campanario, María del Carmen (Date of defense: 2021-05-27)

    Macrophages polarization from an inflammatory to a tolerogenic state occurs in both physiological and pathological, and this reprogramming is key in the development of several diseases as different as atherosclerosis or ...

    Seguridad y eficacia de varnimcabtagene autoleucel (ARI-0001) en síndromes linfoproliferativos CD19 positivos 

    Ortiz-Maldonado Gibson, Valentín (Date of defense: 2022-10-26)

    [spa] En términos generales, el pronóstico de los síndromes linfoproliferativos originados en el linfocito B es francamente desfavorable una vez estos recaen o son refractarios (R/R) a la primera o posteriores líneas de ...

    Seqüeles dentals en adolescents sotmesos a tractament oncològic durant la primera infància 

    Rabassa Blanco, Judit (Date of defense: 2022-12-16)

    [cat] El càncer infantil és una de les principals causes de mortalitat durant la infància i l’adolescència. Segons l’Associació Espanyola contra el càncer, 1500 nens/es de 0 a 14 anys són diagnosticats anualment d’aquesta ...

    Sleep-Disordered Breathing in Children with Cleft Palate 

    Moraleda Cibrián, Marta (Date of defense: 2022-07-11)

    [eng] INTRODUCTION: One in 700 newborns in the United States is born with cleft palate every year. It is estimated that the prevalence of sleep-disordered breathing symptoms in children with cleft palate, compared with ...

    Spatial learning in the network of hippocampal place cells: Altering memory using a mouse model of passive transfer of antibodies from patients with anti-NMDAR encephalitis 

    Zamani Mozafarabadi, AmirPasha (Date of defense: 2022-12-16)

    [eng] Anti-NMDAR encephalitis is the most frequent antibody-mediated encephalitis known to date, in which patients develop specific antibodies directed against the N-methyl-D-aspartate receptors (NMDARs) in the central ...

    Spatiotemporal dynamics of the cerebral cortex: from unconscious brain states towards consciousness 

    Camassa, Alessandra (Date of defense: 2021-07-23)

    Understanding the dynamics of the brain that gives rise to conscious experience and that underscore the transition through different brain states is one of the central problems of today’s neuroscience. The cerebral cortex ...

    Study of collective cell durotaxis as an active wetting phenomenon 

    Pallares Pallares, Macià Esteve (Date of defense: 2022-03-08)

    Cell migration is essential to many biological processes. In adult organisms, it is crucial for wound healing, homeostasis, and immune response, whereas aberrant cell migration potentially leads to pathology. For example, ...

    Synaptic and circuit mechanisms of working memory and their dysfunction in anti-NMDA receptor encephalitis and schizophrenia 

    Stein, Heike (Date of defense: 2020-11-13)

    [eng] In this thesis, I investigate different synaptic and circuit mechanisms of working memory, how their interaction produces specific working memory biases, and how their disruption in psychiatric or neurological disease ...

    The implementation of Advanced Practice Nursing in Catalonia 

    Sevilla Guerra, Sonia (Date of defense: 2018-06-01)

    INTRODUCTION: The expansion of professional roles has been proved to be an innovative solution across some countries in order to help address healthcare integration, coordination, continuity, access and health care ...

    The new bioactive hydraulic sealers in endodontics 

    Bardini, Giulia (Date of defense: 2022-11-30)

    [eng] INTRODUCTION: In the last twenty years, sealing cements based on tricalcium silicate cements have been introduced into the market for orthograde filling of the root canal system. These silicate-based sealing cements ...

    The role of genome architecture in normal and neoplastic B cells: a multi-omics approach 

    Vilarrasa Blasi, Roser (Date of defense: 2020-10-09)

    [eng] Nuclear organization and its impact on gene regulation have started to be elucidated thanks to the development of chromosomal conformation capture techniques. In this doctoral thesis, in situ Hi-C data and nine ...

    El tipo de donante, la hemoglobina basal y la amplitud máxima del coágulo del tromboelastograma basal: cofactores determinantes de la transfusión de concentrados de hematíes en el trasplante hepático 

    Viguera Fernández, Laura (Date of defense: 2022-11-15)

    [spa] La primera hipótesis de esta tesis doctoral, establece que la hemoglobina basal (previa al trasplante hepático) y la amplitud máxima del coagulo del tromboelastograma, pueden predecir la transfusión intraoperatoria ...

    Tomografía por Emisión de Positrones cuantificada en la evaluación prequirúrgica de la epilepsia 

    Mayoral Peñalva, Maria (Date of defense: 2019-07-24)

    La epilepsia es una enfermedad con una elevada prevalencia e impacto sociosanitario. Aproximadamente un tercio de los pacientes son resistentes al tratamiento farmacológico y en estos casos debe considerarse la cirugía ...

    Towards precision medicine in pediatric liver cancer: discovery and validation of prognostic biomarkers 

    Carrillo Reixach, Juan (Date of defense: 2022-12-19)

    [eng] Pediatric liver cancer is considered a rare disease and represents <3% of all pediatric tumors worldwide. The main types of liver tumors in the pediatric age group are hepatoblastoma (HB) and hepatocellular carcinoma ...

    Tracking preformed serological and T-cell alloimmune memory together with donor/recipient Molecular Human Leukocyte Antigen (HLA) disparity to improve immune-risk stratification in Kidney Transplantation 

    Meneghini, Maria Antonia Emilia (Date of defense: 2021-10-21)

    INTRODUCTION: The presence of a donor-specific alloimmune response negatively impacts allograft outcomes, being associated to risk of rejection and premature graft loss. Alloimmunity can be both preformed (memory) or can ...

    Tractament de l'hepatitis C crònica amb agents antivirals directes en pacients majors de 65 anys 

    Amorós Reboredo, Patrícia (Date of defense: 2020-11-26)

    ANTECEDENTS DEL TEMA En els últims anys els agents antivirals directes aprovats pel tractament de l’hepatitis C han permès l’accés al tractament a grups de pacients que anteriorment no es tractaven pel risc que comportava ...