Facultat de Medicina i Ciències de la Salut

Recent Submissions

Epic Battles in Myeloma: Deciphering the Role of PVR in the Fight Between Tumors and Cytotoxic Cells 

Martinez Verbo, Laura (Date of defense: 2024-12-20)

[eng] HYPOTHESIS: Epigenetics influence cancer and recently epigenetic plasticity has been included as a new hallmark of cancer described in the latest published work of Hanahan113. Growing scientific evidence has pointed ...

The pulleys: from the anatomical and histological basis to sonoanatomical characterization 

Coronel Tarancón, Luis (Date of defense: 2024-12-20)

[eng] INTRODUCTION: Digital annular pulleys (DAP) are important anatomical structures for finger function. The anatomy, histology and imaging assessment of DAP, particularly at the level of their entheses, has not been ...

Uncovering TET2 chromatin targets at the leukemic onset 

Lazarenkov, Aleksey (Date of defense: 2024-12-18)

[eng] Epigenetic modifications, including DNA methylation, have been shown to play a prominent role in influencing cell identity in hematopoiesis. However, its role in gene regulation during differentiation remains poorly ...

Factores Psicológicos Asociados al Desarrollo y Curso de las Adicciones Comportamentales o Adicciones sin Sustancia 

González Bueso, Mª Vega (Date of defense: 2024-12-19)

[spa] INTRODUCCIÓN: Existe un debate epistemológico centrado en determinar cuál es el enfoque diagnóstico más adecuado en el campo de la salud mental, enfrentando modelo categorial frente al dimensional. El categorial ...

Psiquiatría nutricional aplicada al trastorno bipolar 

Costa, Susana Patrícia Gomes da (Date of defense: 2024-12-18)

[spa] INTRODUCCIÓN: El trastorno bipolar (TB) es un trastorno crónico del estado de ánimo caracterizado por fluctuaciones del estado de ánimo, que afecta a un amplio rango de población y se relaciona con un importante ...

Valoración de la reserva ovárica. Estudio de parámetros hormonales y ecográficos 

Peralta Flores, Sara (Date of defense: 2024-12-17)

[spa] INTRODUCCIÓN: Los marcadores de reserva ovárica son excelentes predictores de respuesta ovárica, pronóstico y riesgo de complicaciones en FIV/ICSI, aunque no son predictores de fertilidad natural. La determinación ...

Advancing precision medicine in cancer and COVID-19 with bioinformatics: a multifaceted affair 

García Prieto, Carlos Antonio (Date of defense: 2024-12-14)

[eng] Advancing precision medicine requires integrating bioinformatics to unravel complex biological data and translate these insights into clinical applications. This thesis explores the role of bioinformatics in enhancing ...

Sleep disorders in immune-mediated synaptic encephalopathies 

Muñoz Lopetegi, Amaia (Date of defense: 2024-12-17)

[eng] INTRODUCTION: Autoimmune encephalitis (AEI) is an inflammatory disease of the central nervous system, caused by specific antibodies against synaptic or neural surface proteins. More than twenty have been described ...

Unveiling the role of the Mediator complex in Ewing sarcoma tumorigenesis 

Cuervas Oliveras, Irene (Date of defense: 2024-12-17)

[eng] Ewing sarcoma is an aggressive tumor arising in bones and soft tissues that affects children and young adults. This disease is determined by an aberrant chromosomal translocation that forms an oncogenic fusion protein, ...

Eficacia y seguridad de las nuevas técnicas de resección endoscópica para neoplasias precoces gastrointestinales 

Uchima Koecklin, Hugo Ikuo (Date of defense: 2024-12-17)

[spa] INTRODUCCIÓN: La detección y caracterización endoscópica de lesiones neoplásicas precoces (lesiones superficiales confinadas a la mucosa o submucosa que en casos seleccionados tienen un riesgo muy bajo de metástasis ...

IKKα modulates metastatic activity by preventing Tight Junctions stabilization and collective cell migration 

Alvarez Villanueva, Daniel (Date of defense: 2024-12-16)

[eng] The IKKα kinase was previously found to activate multiple oncogenic and therapy-resistance pathways, including ATM/DDR, BRD4, and JAK/STAT3, independently of canonical NF-KB signaling. Here, we show that suppression ...

New therapeutic approaches to target myofibroblast activation in liver pathologies: fibrosis and cholangiocarcinoma 

Amengual Segura, Josep (Date of defense: 2024-12-16)

[eng] HYPOTHESES: Iron accumulation and senescence mediate fibrosis progression in kidney and lung. In the liver, iron overload, specifically in hepatocytes, has been linked to hepatic diseases such as hereditary ...

Diagnóstico de la causa de muerte y caracterización de infecciones fatales en muestras post mortem en países de baja renta 

Hurtado Negreiros, Juan Carlos (Date of defense: 2024-12-13)

[spa] INTRODUCCIÓN: La ausencia de datos confiables sobre las causas de muerte se ha señalado como un factor limitante para reducir la mortalidad en el mundo. Entendemos que para poder desarrollar un planteamiento y ...

Understanding Adiposity through Body Shape Phenotypes: Implications for Cancer Risk, Inflammation, and Prediction 

Peruchet Noray, Laia (Date of defense: 2024-12-13)

[eng] INTRODUCTION. Obesity is characterized by excess body fat (adiposity) and is a major determinant of disability. Obesity is mainly measured by body mass index (BMI) although it presents several limitations. For instance, ...

Unraveling the molecular basis of the metastatic process in Ewing sarcoma: insights into the role of LOXHD1 and PARP14 

Sánchez Serra, Sara (Date of defense: 2024-12-13)

[eng] HYPOTHESIS AND OBJECTIVES 1. Hypothesis: Metastasis is the worst prognostic factor in EwS patients, dropping patients’ overall survival to less than 30 %43. Further, about 25 % of patients present with metastatic ...

Evaluación de factores de riesgo de retrombosis y sangrado en pacientes con enfermedad tromboembólica venosa 

Gabara Xancó, Cristina (Date of defense: 2024-12-13)

[spa] HIPÓTESIS: 1. Establecer las ratios de recurrencia, sangrado mayor, y las tasas de mortalidad tras un primer episodio de trombosis no provocada, puede ayudar en la decisión de mantener o suspender la anticoagulación ...

Brain mechanisms and psychological determinants of mental health resilience. Learning from the COVID-19 pandemic 

Cabello Toscano, María del Rocío (Date of defense: 2023-11-06)

[eng] When confronted with a stressful situation, our reactions can vary greatly. In general, the population comes across to be resilient, being able to resist or adapt to disturbances. However, this is not the case for ...

Radioterapia estereotáctica en lesiones óseas. Factor tiempo como predictor de supervivencia 

Pérez Montero, Héctor (Date of defense: 2023-06-22)

[spa] INTRODUCCIÓN: En los últimos años se ha producido una mejora en el pronóstico de los pacientes metastásicos gracias a los avances en terapias oncológicas. Debido a ello, el abordaje radical de las metástasis ha ido ...

Generation of high-performance cellular model for Huntington’s disease 

Lam, Lam (Date of defense: 2024-12-13)

[eng] Huntington’s disease (HD) is an autosomal dominant inherited neurological disease, which is caused by mutation in the HTT gene that encodes for the huntingtin protein. The disease leads to involuntary movements, ...

ZeGRIN: Using zebrafish GRIN-related disorders models for disease understanding and therapeutic discovery 

Locubiche Serra, Sílvia (Date of defense: 2024-12-13)

[eng] The glutamatergic neurotransmission system is crucial for brain function, and its dysregulation is involved in several neurological diseases, including developmental, psychiatric and neurodegenerative disorders. ...