Facultat de Medicina i Ciències de la Salut

Envíos recientes

CHEMSEX: Caracterización de usuarios de drogas en contexto sexual y su asociación con VIH, VHC y otras enfermedades de transmisión sexual 

Mora Cañizo, Lorena de la (Fecha de defensa: 2023-01-17)

[spa] Desde el descubrimiento del VIH/SIDA y el inicio de la epidemia en la década de los años ochenta, esta enfermedad ha afectado a grupos que viven en condiciones de vulnerabilidad. Los primeros casos fueron descritos ...

Isolation, Culture and Characterization of Klinefelter Spermatogonial Stem Cells 

Galdón López, Guillermo (Fecha de defensa: 2023-01-13)

[eng] INTRODUCTION: Klinefelter syndrome (KS) is a chromosomal abnormality that affects approximately 1 in 500-1000 male births. Their most frequent karyotype is 47XXY and up to 10% of them present significant mosaicism ...

Biochemical and mechanical changes of the extracellular matrix during lung metastasis 

Narciso, Maria Leonor Barreto Torres de Mendonça (Fecha de defensa: 2023-01-12)

[eng] The mechanical properties of a tumor play an important role in cancer progression and therapeutic response. In fact, the stiffening of the tumor microenvironment has been linked to therapy resistance and an increased ...

Study of the effects of mechanical force on nucleo-cytoplasmic transport 

Granero Moya, lgnasi (Fecha de defensa: 2023-01-12)

[eng] Mechanical force controls fundamental cellular processes in both healthy and diseased cells, and more and more evidence shows that the nucleus experiences and feels the forces applied to it. These forces can lead to ...

Understanding the genotype-phenotype relation between PIK3CA variant signalling and vascular malformations 

Maes, Louis (Fecha de defensa: 2025-04-30)

[eng] Vascular malformations (VMs) represent a diverse group of diseases with complex yet poorly understood underlying mechanisms. Causative gain-of-function mutations in PIK3CA have been associated with the onset of these ...

Exploring the use of tolerogenic dendritic cells and pore-forming toxins in the context of oncolytic adenoviruses 

Moya Borrego, Laura (Fecha de defensa: 2025-04-30)

[eng] Oncolytic viruses (OVs), engineered to infect preferentially and selectively replicate within cancer cells while sparing healthy tissues, have regained interest in oncology for their potential to restore host anti-tumor ...

Characterization of the Immune System, Hematopoietic Stem Cells, and Molecular Biomarkers in Myelodysplastic Syndromes and Chronic Myelomonocytic Leukemia: Implications for Improved Stratification and Treatment. 

Rodríguez-Sevilla, Juan José (Fecha de defensa: 2025-04-28)

[eng] INTRODUCTION: Myelodysplastic syndromes (MDS) and chronic myelomonocytic leukemia (CMML) are clonal hematological neoplasms characterized by ineffective hematopoiesis, chronic inflammation and complex molecular ...

Study of the acquisition and maintenance of antibody and cellular immune responses against SARS-CoV-2 in longitudinal cohorts 

Rubio Bodí, Rocío (Fecha de defensa: 2025-04-30)

[eng] The COVID-19 pandemic has underscored the importance of understanding adaptive immune responses to SARS-CoV-2 to optimize vaccination strategies and public health interventions. Adaptive immune responses generate ...

Avances en la Caracterización del Sustrato Arrítmico y Procedimientos de Ablación: Integración de Catéteres de Alta Densidad y Nuevas Aplicaciones de Resonancia Magnética Cardíaca 

Vázquez Calvo, Sara (Fecha de defensa: 2025-04-29)

[spa] Las arritmias ventriculares en pacientes con cardiopatía estructural son una de las principales causas de muerte y morbilidad en dicha población. Su origen se haya en cicatrices miocárdicas que pueden ser identificadas ...

Development of a brain-penetrant formulation of SN-38 using shuttle peptides for the treatment of pediatric high-grade gliomas 

Resa Parés, Clàudia (Fecha de defensa: 2025-04-25)

[eng] Drug delivery to the brain remains a significant challenge due to the integrity of the blood-brain barrier (BBB), which protects the brain tissue. In this study, we present the design and preclinical development of ...

Prevalence of unexpected positive intraoperative cultures in hip arthroplasty and their impact on the result and survival of the prosthesis 

Vargas-Reverón, Caribay (Fecha de defensa: 2025-04-23)

[eng] INTRODUCTION: Total hip arthroplasty (TKA) is performed more and more frequently due to the increase in indications and longer life expectancy. Approximately 12% will require revision surgery at 10-15 years, with ...

Impact of new pharmacological strategies for the treatment of acute myocardial infarction: study of the effects and synergy of sacubitril/valsartan and empagliflozin 

Martínez Falguera, Daina (Fecha de defensa: 2025-04-23)

[eng] INTRODUCTION: The introduction of new drugs such as sacubitril/valsartan and empagliflozin has markedly improved clinical outcomes in patients with heart failure (HF). The role of these drugs in HF is well-established; ...

Estudio anatómico y ecográfico del nervio radial en su recorrido por el brazo y antebrazo 

García Martínez, Jose (Fecha de defensa: 2022-11-11)

[spa] El nervio radial realiza un tortuoso camino por el brazo y antebrazo relacionándose con diferentes estructuras anatómicas que están envueltas por la fascia muscular profunda de la extremidad superior (EESS) y más ...

Unravelling Neural Heterogeneity in Mental Disorders: The Role of Genetics, Cognition, and Comorbidities 

Fortea González, Lydia (Fecha de defensa: 2025-04-09)

[eng] INTRODUCTION: Mental disorders are one of the main causes of disability worldwide, with a significant impact on the quality of life of those affected and a great economic and social burden on society. Despite advances ...

Implementación de un sistema de dosimetría in vivo mediante detectores de centelleo plástico en braquiterapia 

Herreros, Antonio (Fecha de defensa: 2025-04-16)

[spa]INTRODUCCIÓN: La braquiterapia (BQT) es una forma de radioterapia que utiliza fuentes radiactivas encapsuladas para administrar tratamientos a corta distancia. Esta técnica permite una alta dosis de radiación en ...

Aplicación del Índice de Desaturación-Distancia (DDR) en pacientes con Hipertensión Arterial Pulmonar (HAP): Seguimiento y Pronóstico de Supervivencia 

Alsina Restoy, Javier (Fecha de defensa: 2025-04-11)

[spa] INTRODUCCIÓN: En la introducción, se aborda una revisión exhaustiva sobre la prevalencia, la etiopatogenia, el diagnóstico y el tratamiento de una de las enfermedades respiratorias crónicas más importantes en el ...

Management of patients with acute infections in resource-limited settings: towards new host biomarker-based tools to improve triage and risk stratification 

Balanza Lombardia, Núria (Fecha de defensa: 2025-04-04)

[eng] INTRODUCTION: Acute infections are a leading reason for seeking healthcare globally. However, the triage and risk stratification of patients with such infections remain challenging across different healthcare levels. ...

Sarcopenia y fatiga en la artritis reumatoide. Prevalencia y factores determinantes 

Valencia Muntalà, Lídia (Fecha de defensa: 2025-04-03)

[spa] Esta tesis doctoral aborda dos comorbididades clave en pacientes con artritis reumatoide (AR): la sarcopenia y la fatiga. Ambas condiciones representan importantes retos clínicos debido a su prevalencia, impacto en ...

Identification and Preclinical Evaluation of Asenapine Maleate as a Direct Survivin Inhibitor for Lung Cancer Therapy and Sensitization to Proapoptotic Treatments 

Benítez García, Cristina (Fecha de defensa: 2025-04-04)

[eng] A major challenge in cancer treatment is the ability of cancer cells to evade cell death, a hallmark of cancer that drives both disease progression and treatment resistance. Overexpression of anti-apoptotic proteins, ...

A long-lasting porcine model of ARDS caused by Pseudomonas aeruginosa and Ventilator-Induced Lung Injury 

Arrieta Ruiz, Marta (Fecha de defensa: 2025-04-03)

[eng] INTRODUCTION: Existing animal models of acute respiratory distress syndrome (ARDS) are varied and often differ compared to human ARDS in their main features of lung damage, etiology, pathophysiology, or maintenance ...