Falcones Olarte, Kevin Bryan (Date of defense: 2022-04-22)
HYPOTHESIS 1: The frequency and the plateau values displayed by OSA-related IH patterns are important to understand the endothelial dysfunction triggered by OSA. AIM 1: A) General: To evaluate ...
Goicoechea Barrenechea, Leire (Date of defense: 2021-06-16)
X-linked adrenoleukodystrophy (X-ALD) is a rare neurometabolic disease characterized by the loss of function of the peroxisomal transporter ABCD1, which leads to an accumulation of very long-chain fatty ...
Castro Barquero, Sara (Date of defense: 2022-05-30)
[eng] INTRODUCTION: Metabolic syndrome (MetS) is a clustering of different cardiovascular and cardiometabolic risk factors. In developed countries, MetS prevalence has risen to 20- 25% in the adult ...
Baroni, Matteo Libero (Date of defense: 2020-07-17)
[eng] Resistance to standard therapy and relapses are observed in several cases of both myeloid and lymphoid cell malignancies. Such phenomenon poses unquestionable limits to the utility of current ...
Cabot, Débora (Date of defense: 2020-09-28)
[eng] Analysis of KRAS phosphorylation and KRAS effector domain as targets for cancer therapy Oncogenic mutations of KRAS are found in the most aggressive human tumors, including colorectal cancer (CRC). ...
Vilarrasa Blasi, Roser (Date of defense: 2020-10-09)
[eng] Nuclear organization and its impact on gene regulation have started to be elucidated thanks to the development of chromosomal conformation capture techniques. In this doctoral thesis, in situ Hi-C ...
Zanoncello, Jasmina (Date of defense: 2020-07-30)
[ENG] Venous malformations (VM), the most frequent type of vascular malformations, are localized developmental defects occurring during vascular morphogenesis that generat dilated, tortuous venous ...
Dubreuil Vall, Laura (Date of defense: 2020-10-28)
[eng] Executive function is defined as a subset of high-order cognitive functions (including working memory, inhibition, initiation and monitoring) that sustain adaptive goal-directed behavior and ...
Stein, Heike (Date of defense: 2020-11-13)
[eng] In this thesis, I investigate different synaptic and circuit mechanisms of working memory, how their interaction produces specific working memory biases, and how their disruption in psychiatric ...
Solé Sánchez, Patricia (Date of defense: 2020-12-09)
[eng] Regulatory cells are essential to immune homeostasis. Both autoimmune diseases and the progression of cancer are related to alterations in the development and/or function of the regulatory ...