Facultat de Medicina i Ciències de la Salut: Recent submissions
Now showing items 341-360 of 403
Detection of early cerebral amyloid-β deposition by PET imaging and its downstream effect
Alzheimer's disease (AD) is the leading cause of dementia worldwide. This disease, however, starts decades before any clinical symptom appears with the accumulation in the brain of aggregates of two main proteins: amyloid-β ...
Foetal Stem Cell conversion as a new mechanism of therapy resistance in intestinal cancer
Current therapy against colorectal cancer (CRC) is based on DNA-damaging agents that eradicate highly proliferative malignant cells. Whether sublethal chemotherapy affects tumour cell behaviour and impacts on patient outcome ...
Plasma membrane mechanosensing upon stretch-induced topography remodelling
Five years ago, I started walking this path that now seems like an entire life. Although everyone around tried to explain how this would feel, none of their explanations could have match what it has been in the end. And ...
Role of ZEB factors in macrophages in atherosclerosis and ovarian cancer
Macrophages polarization from an inflammatory to a tolerogenic state occurs in both physiological and pathological, and this reprogramming is key in the development of several diseases as different as atherosclerosis or ...
CRISPR-Cas9 to model retinitis pigmentosa caused by mutations in splicing factors in C. Elegans
Retinitis pigmentosa (RP) is a rare, heterogenic, and hereditary disease that produces gradual loss of the visual field and can cause blindness. Mutations causing RP are still unknown in about 50% of the cases. By CRISPR-Cas9, ...
Regulation of lipid and redox metabolism in X-linked Adrenoleukodystrophy (X-ALD): therapeutic implications
X-linked adrenoleukodystrophy (X-ALD) is a rare neurometabolic disease characterized by the loss of function of the peroxisomal transporter ABCD1, which leads to an accumulation of very long-chain fatty acids (VLCFA), ...
Intraoperative neurophysiological monitoring through pedicle screw stimulation
OBJECTIVES: Study the interdependence between stimulus duration and stimulus strength, to observe if by changing the stimulus duration, the current threshold levels will also change during pedicle screw stimulation. Then ...
A translational bioinformatics approach to improve genetic diagnostics of hereditary cancer using next-generation sequencing data
This PhD thesis has been carried out with the aim of improving, from a bioinformatic-based approach, the genetic diagnostics of hereditary cancer. More specifically, the aims were: 1. To perform a comprehensive evaluation ...
Psychological characteristics, sexual function and quality of life in infertile women with polycystic ovary syndrome
Polycystic ovary syndrome (PCOS) is a multisymptomatic disorder and the most common endocrinopathy among women of reproductive age. Psychopathological problems are a relatively new aspect of PCOS for clinicians. Only about ...
Effect of maternal HIV and malaria on the transplacental transfer of antibodies against prevalent pathogens and vaccines in Mozambican women
Infectious diseases are one of the main causes of mortality in newborns born in Mozambique. Transplacental transfer of antibodies is essential for conferring protection during the first months of life against these ...
Estudio de enfermedades crónicas de salud y funcionamiento en personas de mediana edad y mayores desde una perspectiva epidemiológica
El incremento de la esperanza de vida suele traducirse en un mayor número de años vividos con discapacidad debido a una mayor prevalencia de enfermedades crónicas de salud. La multimorbilidad (MM) es cada vez más común y ...
Myotonic Dystrophy Type 1: the heterogeneity of a complex disease in a global research approach
Myotonic Dystrophy Type 1 (DM1) is a complex disease with a dominant autosomic inheritance caused by a CTG expansion at the end of the DMPK gene. This expansion is very unstable and it is known that is correlated with the ...
CPEB4-Driven adipocyte reprogramming is required for adipogenesis and pathological inflammation
Obesity is reaching pandemic dimensions and is an established instigator of many diseases, such as non alcoholic fatty liver disease, the most prevalent liver disease worldwide. Most studies in this regard have been focused ...
CD5 as immunomodulatory agent in experimental models of fungal infection
CD5 is a scavenger receptor mainly expressed on lymphoid (T and B1a) cells but also on some minor myeloid (Mϕ and DCs) cell subsets. It is long known to negatively modulate differentiation and activation signals mediated ...
Anticuerpos frente a péptidos carbamilados en la artritis reumatoide: Papel en el reumatismo palindrómico, la enfermedad pulmonar intersticial y la respuesta terapéutica
INTRODUCCIÓN: La artritis reumatoide (AR) es una de las enfermedades autoinmunes más frecuentes y la forma de artritis inflamatoria más común afectando en torno al 1% de la población mundial. Además, es una enfermedad ...
Noves metodologies per al tractament de bacteris creixent en forma de biofilm
Les infeccions bacterianes han esdevingut un greu problema a escala mundial per culpa del mal ús que hom ha fet dels antibiòtics. L’adquisició de resistències als antimicrobians s’ha accelerat i cada cop hi ha més bacteris ...
Mechanisms and modulation of cortical rhythms and complexity
Throughout various brain states, billions of neurons interact resulting in a variety of cortical rhythms accompanied by switches between behavioral states (Gervasoni et al., 2004). As a result of the specific (1) ...
Tractament de l'hepatitis C crònica amb agents antivirals directes en pacients majors de 65 anys
ANTECEDENTS DEL TEMA En els últims anys els agents antivirals directes aprovats pel tractament de l’hepatitis C han permès l’accés al tractament a grups de pacients que anteriorment no es tractaven pel risc que comportava ...
Mitochondrial and autophagic alterations in human-derived cell models of Parkinson's disease related to LRRK2 (G2019S) and GBA (N370S) mutations
Parkinson's disease (PD) is the second most common neurodegenerative disease, and the most common movement disorder in the world population. In most cases its aetiology is still unknown, however, mitochondrial alterations ...
Deep Learning System for the Automatic Classification of Normal and Dysplastic Peripheral Blood Cells as a Support Tool for the Diagnosis
Clinical pathologists identify visually many morphological features to characterize the different normal cells, as well as the abnormal cell types whose presence in peripheral blood is the evidence of serious diseases. ...
