Facultat de Medicina i Ciències de la Salut: Recent submissions
Now showing items 81-100 of 561
Análisis de la autogestión del cuidado de la diabetes tipo 1 en población infantil y adolescente
[spa] INTRODUCCIÓN: La diabetes tipo 1 (DT1) es una enfermedad autoinmune que destruye las células beta del páncreas, las cuales producen insulina. La insulina es una hormona vital cuya función principal es facilitar ...
Inhibició del catabolisme de la lisina mitjançant teràpia gènica com a aproximació terapèutica per a l’Acidúria Glutàrica tipus 1
[cat] L'acidúria glutàrica tipus 1 (AG1) és una malaltia metabòlica hereditària causada per la deficiència enzimàtica de glutaril-CoA deshidrogenasa (GCDH), una proteïna implicada en el catabolisme de la lisina, el triptòfan ...
Inhibition of the PI3K/Akt pathway as a therapeutic strategy for pediatric-type diffuse high-grade gliomas
[eng] This thesis aims to contribute to the field of therapy development in pHGG. These deadly cancers infiltrate structures such as the brainstem, cerebellum, thalamus and spinal cord, rendering surgery unfeasible. All ...
Genetic and Epigenetic Contributions to Psychotic Disorders: From Early Vulnerability to Clinical Onset in Precision Psychiatry
[eng] INTRODUCTION: Psychotic disorders are complex in their etiology, as they involve genetic, epigenetic and environmental factors. This complexity translates into a great clinical heterogeneity, with different stages ...
Deciphering tumorsphere biology in ovarian cancer
[eng] Epithelial ovarian cancer (EOC) is the fifth-leading cause of cancer death among women and the most lethal gynecological malignancy. High-grade serous ovarian carcinoma (HGSOC) is the most prevalent and aggressive ...
Efectividad de la acupuntura como estrategia complementaria previa a la inducción programada del parto
[spa] La inducción del parto es un procedimiento habitual en el embarazo, consiste en provocar el inicio de las contracciones de parto, bien por métodos mecánicos o farmacológicos, antes de que éste se inicie de forma ...
Transcriptome analysis and functional characterization of Plasmodium vivax spleen and bone marrow dependent genes and the role of the extracellular vesicles in cryptic niche formation
[eng] INTRODUCTION: Plasmodium vivax is the most widespread malaria parasite, with 2.8 billion people at risk across regions from Southeast Asia to the Americas. In 2022 alone, approximately 6.9 million clinical cases ...
New biomarkers of cardiometabolic risk: Hypothalamus-pituitary-adrenal axis and subclinical atherosclerosis. From type 1 diabetes to chronic kidney disease
[eng] INTRODUCTION: Type 1 diabetes (T1D) and chronic kidney disease (CKD) are populations with high cardiovascular risk and mortality despite recent improvements in healthcare. New strategies are needed to tackle ...
Deciphering the trajectory of iPSC-derived hepatic stellate cells in physiology and disease
[eng] Hepatic stellate cells (HSCs) are mainly responsible for liver fibrosis, a common feature in all liver diseases, regardless of their etiology, and which currently has no treatment. In addition, fibrosis is directly ...
Generación de una fuente de linfocitos T alogénicos para su uso en terapia CAR-T contra enfermedades oncológicas e infecciosas
[spa] El uso de linfocitos T de donantes para la inmunoterapia celular tiene en el rechazo por alogenicidad la principal limitación. En este sentido mientras que la reducción en la expresión de las moléculas del complejo ...
Advancing in Endometrial Cancer Prevention: Exploring the Role of Circadian Disruption Factors and the Sensitivity of Cervicovaginal Cytology for its Detection
[eng] INTRODUCTION: Endometrial cancer (EC) is the most common gynecological tumor in developed countries, with an increasing incidence due to population aging and growing obesity. This cancer is estrogen-dependent, so ...
Understanding the immunogenicity of RTS,S/AS0 vaccination in African children: antigen glycosylation, booster dose and off-target antibody responses
[eng] INTRODUCTION: Malaria, caused by Plasmodium falciparum, remains a major public health concern, especially in children under 5 years of age in sub-Saharan Africa. RTS,S/AS01E is the first of two malaria vaccines ...
Role of Sirtuins in haematopoiesis and leukaemia
[eng] Haematopoiesis is the process by which haematopoietic stem cells replenish all blood cell types, including myeloid cells and lymphocytes, throughout life in mammals. In particular, B lymphocytes or B-cells are the ...
Elucidating variable disease severity of X-linked adrenoleukodystrophy through multiomics and metagenomics of gut microbiome
[eng] X-linked adrenoleukodystrophy (X-ALD) is a rare and devastating neurodegenerative disorder characterized by inflammatory demyelination of the brain and/or axonal degeneration in the spinal cord. This arises from a ...
Mechanobiology of single cell migration on patterned fibronectin gradients
[eng] Directed cell migration along gradients of extracellular matrix (ECM) density – a process called haptotaxis – plays a central role in morphogenesis, the immune response, and cancer invasion. It is commonly assumed ...
Development of Epstein-Barr Virus-Specific T cells expressing anti-CD19 Chimeric Antigen Receptor for cancer immunotherapy
[eng] T cells expressing chimeric antigen receptors (CAR-T) targeting the CD19 antigen have been proven to be one of the most promising treatments for B cell neoplasms. However, CAR-T therapy presents certain limitations, ...
Proyecto OntoPharma. Diseño, desarrollo e implementación de un sistema de soporte a la decisión clínica basado en ontologías
[spa] INTRODUCCIÓN: La seguridad del paciente en el uso del medicamento sigue siendo un desafío, especialmente en el ámbito hospitalario debido a su complejidad. Asimismo, la mayoría de los errores ocurren durante la etapa ...
Analysis of multidisciplinary clinical practice in cancer care and factors related to the professional roles of the care teams: A qualitative and quantitative evaluation in the framework of the Catalan Health System
[eng] INTRODUCTION: The last 20 years have seen significant progress in cancer control, driven by multiple advances in different areas such as technology, surgery procedures, medical treatments, but also by innovation in ...
Estudio sobre las complicaciones quirúrgicas derivadas del trasplante de páncreas en el Hospital Clínic de Barcelona
[spa] INTRODUCCIÓN: El trasplante de páncreas (TxP) es un procedimiento quirúrgico complejo destinado a restaurar la normoglucemia y la independencia a la insulina exógena, principalmente en pacientes con diabetes mellitus ...
COVID-19 clinical and epidemiological profiles. Risk-group characterization in patients with chronic conditions and multimorbidity
[eng] INTRODUCTION: In December 2019 an outbreak of pneumonia cases of unknown etiology was reported in Wuhan, China. The disease, eventually known as COVID-19, was caused by the novel Severe Acute Respiratory Syndrome ...
