Bariatric surgery and diet change in rats

dc.contributor
Universitat de Barcelona. Departament de Bioquímica i Biomedicina Molecular
dc.contributor.author
Rossell Rusiñol, Joana
dc.date.accessioned
2021-12-13T11:43:49Z
dc.date.available
2021-12-13T11:43:49Z
dc.date.issued
2021-02-26
dc.identifier.uri
http://hdl.handle.net/10803/672931
dc.description.abstract
An unbalanced, unhealthy diet is one of the main causes leading to obesity and the apparition of comorbidities. Bariatric surgery is currently the most effective and durable treatment against obesity. Despite being a commonly performed technique is still much investigated, as the mechanisms by which the weight is reduced and the comorbidities are improved are still largely unknown. Implementing healthier dietary habits after BS appears to be decisive to maintain the obtained benefits, besides the mechanistic restriction of the BS. On the other hand, dieting alone is also described to have beneficial effects if well implemented. Based on this information, we established the following hypothesis: A high-fat diet will induce modifications on a rodent model, such as increasing adiposity, unbalancing the gut microbiota, and modifying the fatty acid composition of several organs. The deleterious effects produced by the high-fat diet will be partly improved by either vertical sleeve gastrectomy or by a change of diet, while the combination of both actions will have a synergistic effect and a better outcome than both actions alone. To explore this hypothesis the following objectives were formulated: • Identify the major modifications caused by the HFD on adiposity, gut microbiota composition, and fatty acid composition in tissues. • Study the effects caused by VSG when the high-fat diet is continued. • Study the effects caused by a change of diet alone. • Study the effects caused by a combination of VSG and a change of diet.
dc.format.extent
170 p.
dc.format.mimetype
application/pdf
dc.language.iso
eng
dc.publisher
Universitat de Barcelona
dc.rights.license
L'accés als continguts d'aquesta tesi queda condicionat a l'acceptació de les condicions d'ús establertes per la següent llicència Creative Commons: http://creativecommons.org/licenses/by-sa/4.0/
dc.rights.uri
http://creativecommons.org/licenses/by-sa/4.0/
*
dc.source
TDX (Tesis Doctorals en Xarxa)
dc.subject
Cirurgia de l'obesitat
dc.subject
Cirugía de la obesidad
dc.subject
Obesity surgery
dc.subject
Dieta
dc.subject
Diet
dc.subject
Microbiota intestinal
dc.subject
Gastrointestinal microbiome
dc.subject.other
Ciències de la Salut
dc.title
Bariatric surgery and diet change in rats
dc.type
info:eu-repo/semantics/doctoralThesis
dc.type
info:eu-repo/semantics/publishedVersion
dc.subject.udc
61
dc.contributor.director
Peinado Onsurbe, Julia
dc.contributor.director
Pardina Arrese, Eva
dc.contributor.tutor
Peinado Onsurbe, Julia
dc.embargo.terms
cap
dc.rights.accessLevel
info:eu-repo/semantics/openAccess


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