3D-printed biomimetic bone grafts: clinical validation and improvement strategies 

    Johansson, Linh Ha Huong Lovisa (Date of defense: 2024-05-06)

    (English) Bone defects pose a major clinical and socio-economic burden and there is a clear need for new bone grafting strategies that take into account the physical-chemical properties of the native bone, to help treat ...

    A computational study of intervertebral disc degeneration in relation to changes in regional tissue composition and disc nutrition 

    Ruiz Wills, Carlos (Date of defense: 2015-07-17)

    Up to 85% of the world population suffers from low back pain, a clinical condition often related to the intervertebral disc (IVD) degeneration (DD). Altered disc cell nutrition affects cell viability and can generate ...

    Biomimetic bone grafts: from the lab to the clinic 

    Raymond, Yago (Date of defense: 2021-09-13)

    Bone grafting is a common medical practice in today’s society, being bone the second most transplanted tissue worldwide after blood. Therefore, it represents a field of major interest for both, biomedical research and the ...

    Design of hybrid fibers for bone tissue engineering 

    Sachot, Nadège (Date of defense: 2014-07-03)

    Most of the conventional organic-inorganic composite materials developed for bone tissue engineering do not possess intimate interactions between their constituents. As a consequence, they generally degrade in a non-homogeneous ...

    Effects of cold atmospheric plasmas on biomaterials: hydrogels and composites with calcium phosphates 

    Solé Martí, Xavier (Date of defense: 2023-07-13)

    (English) This PhD thesis is framed in the European Research Council starting grant project "Atmospheric Pressure plasma meets biomaterials far bone Cancer HEaling (APACHE)". The APACHE project is focused on the design of ...

    Functionalization of titanium surfaces with TGF-beta inhibitor peptides 

    Sevilla Sánchez, Pablo (Date of defense: 2013-07-16)

    Esta tesis queda enmarcada en el ámbito de los biomateriales metálicos, concretamente en superficies de titanio desarrolladas para la regeneración ósea. Las aplicaciones más habituales del titanio como biomaterial son los ...

    Novel multifunctional biomimetic peptides for bone tissue engineering 

    Oliver Cervelló, Lluís (Date of defense: 2022-11-03)

    (English) Mimicking bone extracellular matrix (ECM) is essential to improve cell-material interactions. In this regard, the functionalization of materials with biomolecules derived from the bone ECM is a promising approach. ...

    Tuning the biological performance of calcium phosphates through microstructural and chemical modifications 

    Díez Escudero, Anna (Date of defense: 2017-11-13)

    Bone is the most transplanted tissue after blood. As pointed out by the World Health Organization, musculoskeletal diseases can potentially rise as the fourth largest cause of disability within the next years. Unfortunately, ...