Ara mostrant els elements 73-92 de 107
Pantazi, Eirini (Data de defensa: 2015-07-06)
Ischemia-reperfusion injury (IRI) is an inevitable situation in clinical settings such as liver transplantation and hepatic resection. It develops when blood flow is interrupted for a long period of time (ischemia) and ...
Bassani, Nicklas (Data de defensa: 2017-12-15)
Antiangiogenic drugs are used clinically for treatment of different types of cancers and in the case of renal cell carcinoma (RCC) are now standard first-line treatments (Rini, 2009). Nevertheless, these agents mainly serve ...
Andrés Benito, Pol (Data de defensa: 2019-12-17)
Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) are clinically distinct neurodegenerative diseases that are connected by genetic and pathological overlap. ALS patients present with muscle ...
Avó Freixo, Francisco Duque Projecto (Data de defensa: 2016-10-20)
The microtubule cytoskeleton plays essential roles during cell division, migration, differentiation, defining cell morphology and organizing intracellular transport. The properties of microtubules, such as their stability, ...
Delgado Cirilo, Antonio (Data de defensa: 1986-01-01)
Las modificaciones moleculares que constituyen el objetivo de la presente Tesis pretenden aportar nuevos datos que permitan un más amplio conocimiento de los requisitos estructurales y estereoquímicos necesarios tanto ...
Funtikova, Anna N. (Data de defensa: 2015-11-30)
Cardiovascular diseases (CVD) are the principal cause of mortality worldwide. Lifestyle plays a crucial role in preventing the development of CVD, and one of its key elements is diet, which directly affects cardiometabolic ...
Jiménez Castro, Mónica B. (Data de defensa: 2014-03-04)
In this thesis the role of cyclic AMP , the endoplasmic reticulum stress and adipocytokines such as adiponectin, resistin and visfatin injury in I/R in steatotic liver grafts and non- steatotic undergoing transplantation ...
Cal Pérez-Quevedo, Roi (Data de defensa: 2013-04-19)
Las alteraciones del metabolismo lipídico causadas por la isquemia miocárdica tienen profundos efectos en el estado fisiológico del corazón. En el corazón isquémico, la hipoxia incrementa la formación de vacuolas lipídicas ...
Sima Teruel, Núria (Data de defensa: 2016-06-30)
La cromatina és una estructura nucleoproteica, dinàmica i jeràrquicament organitzada dins del nucli cel•Iular. La seva estructura, organització i funció està controlada al llarg del cicle cel.lular, per processos epigenètics ...
Mayol Ricart, Gemma (Data de defensa: 2013-03-21)
El neuroblastoma (NB) agrupa un espectro muy heterogéneo de tumores que evolucionan de forma radicalmente distinta. La variedad de comportamiento clínico del NB determina el enfoque terapéutico, que puede variar entre un ...
Pulido Villamil, Ximena Carolina (Data de defensa: 2014-07-21)
El estudio de los gamma-péptidos miméticos basados en cis-gamma-amino-L-prolina con capacidad de atravesar la membrana celular en diferentes organismos, constituye una temática de gran interés en el área de biomedicina ...
Izquierdo Serra, Mercè (Data de defensa: 2014-05-06)
Optical tools to control neuronal activity include synthetic photoswitchable ligands of receptors and ion channels. Photoswitches can act either as soluble molecules (photochromic ligands, PCLs) or tethered to the protein ...
Nieves Calatrava, Ingrid (Data de defensa: 2015-11-24)
One of the ultimate goals in biomedicine is to understand the relationship between structure, function, and dynamics of biomolecules in living cells. The biophysical tools designed to gain more insight into metabolism, ...
Guillén Boixet, Jordina (Data de defensa: 2015-12-04)
Cytoplasmic polyadenylation element binding proteins (CPEBs) are a family of RNA-binding proteins essential for the translational regulation of mRNAs in various biological contexts. CPEBs recognize CPE elements in the 3’ ...
Barradas Bautista, Didier (Data de defensa: 2017-03-16)
Proteins are the embodiment of the message encoded in the genes and they act as the building blocks and effector part of the cell. From gene regulation to cell signalling, as well as cell recognition and movement, ...
Villar Menéndez, Izaskun (Data de defensa: 2014-06-06)
La adenosina es un metabolito presente en todo el organismo con distintas funciones fisiológicas. En el sistema nervioso central, desempeña un importante papel como neuromodulador a través de la interacción con sus receptores ...
Román González, Lidia (Data de defensa: 2014-01-31)
Within the hematopoietic system, all mature blood cells are generated. Every differentiation step is characterized by the activation of a new, lineage specific, genetic program and the extinction of the previous one. To ...
Cánovas Bilbao, Begoña (Data de defensa: 2017-07-20)
In normal epithelial cells, p38α has a well-established role as a tumor suppressor. However, recent reports have illustrated pro-tumorigenic functions for the p38α pathway by promoting tumor cell survival and proliferation. ...
Santos Barriopedro, Irene (Data de defensa: 2015-05-08)
Chromatin compaction is regulated by different factors, among them histone posttranslational modifications. There are different histone modifications, and among them, acetylation and methylation of lysine residues. Acetylation ...
de la Puente Robles, Beatriz (Data de defensa: 2015-12-18)
The present Doctoral Thesis focuses on the study of the sigma-1 receptor (σ1R) in the field of pain. This research has been a part of the preclinical σ1R project focusing on drug discovery of σ1R ligands for the treatment ...