Mostrando ítems 1-9 de 9
Chiesa, Giulio (Fecha de defensa: 2015-12-11)
Spinal bulbar muscular atrophy (SBMA) is a member of the polyglutamine (polyQ) expansion diseases family; the most famous of which is Huntington disease (HD). SBMA is caused by the expansion of the ...
Escobedo Pascual, Albert (Fecha de defensa: 2014-11-06)
Nedd4L is a HECT-type E3 ubiquitin ligase (it covalently binds ubiquitin molecules before transferring them to the final substrate). Ubiquitination is a posttranslational modification (PTM) that labels ...
Guillén Boixet, Jordina (Fecha de defensa: 2015-12-04)
Cytoplasmic polyadenylation element binding proteins (CPEBs) are a family of RNA-binding proteins essential for the translational regulation of mRNAs in various biological contexts. CPEBs recognize CPE ...
Campos Gorgona, Nefertiti (Fecha de defensa: 2013-10-15)
En esta tesis se describen los resultados obtenidos en la clonación y caracterización de una nueva transglutaminasa (TGasa) vegetal aislada en arroz (Oryza sativa), la segunda transglutaminasa clonada ...
Bilbao Girona, Ana (Fecha de defensa: 2019-10-30)
El modelo de negocio de I+D de las compañías farmacéuticas está en crisis desde hace décadas debido a los grandes costes y a la baja productividad. En consecuencia, la identificación de nuevos biomarcadores ...
Pallara, Chiara (Fecha de defensa: 2016-02-04)
Proteins are large biomolecules that play essential functional and structural roles within cells and that typically act through their interaction with other proteins and biomolecules, forming highly ...
Jiménez García, Brian (Fecha de defensa: 2016-07-21)
Computing has pushed a paradigm shift in many disciplines, including structural biology and chemistry. This change has been mainly driven by the increase in performance of computers, the capacity of ...
Barradas Bautista, Didier (Fecha de defensa: 2017-03-16)
Proteins are the embodiment of the message encoded in the genes and they act as the building blocks and effector part of the cell. From gene regulation to cell signalling, as well as cell recognition ...
Gil Sepúlveda, Victor Alejandro (Fecha de defensa: 2016-06-09)
The pharmaceutical industry is actively looking for new ways of boosting the efficiency and effectiveness of their R&D programmes. The extensive use of computational modeling tools in the drug discovery ...