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Mostrando ítems 21672-21691 de 43230
Identification and characterization of the molecular pathways regulating the cell cycle-linked pluripotency exit
The self-renewing nature of embryonic stem cells (ESCs) is a consequence of their ability to proliferate while maintaining pluripotency, by means the capacity to differentiate into all adult cell types. Despite the remarkable ...
Identification and characterization of the TRPVs protein-protein interactions, a comprehensive approach to elucidate TRPVs function and regulation
Los canales TRPV son canales de cationes que participan en la homeostasis del calcio con propiedades de activación polimodales. Los TRPVs regulan los niveles de calcio intracelular y promueven ...
Identification and control of diffusive systems applied to charge trapping and thermal space sensors
The work underlying this Thesis, has contributed to the main study and characterization of diffusive systems. The research work has been focused on the analysis of two kind of systems. On the one hand, the dynamics of ...
Identification and evaluation of molecular biomarkers in urine for the detection of prostate cancer
El cáncer de próstata (CP) es una de las mayores causas de muerte entre los hombres de los países desarrollados. Sin embargo, los actuales métodos de diagnóstico presentan una elevada tasa de falsos positivos debido a su ...
Identification and Fate of Known and Unknown Transformation Products of Pharmaceuticals in the Aquatic System
Pharmaceuticals which are used worldwide are designed to facilitate the life for the human society and have an important role in treatment and prevention of disease for both humans and animals. They are ubiquitous in the ...
Identification and functional analysis of intestinal stem cell genes in homeostasis and cancer
The first chapter of this thesis describes the study of intestinal stem cells (ISCs) and their relationship to colon cancer. We describe the transcriptional landscape of intestinal epithelial populations through the use ...
Identification and functional analysis of molecular mechanisms involved in the latency of ER positive breast cancer
Breast cancer is the most frequently diagnosed cancer and remains the second leading cause of death among women in Europe and United States. In this malignancy, metastasis remains to be an incurable condition, and therefore ...
Identification and functional analysis of new factors that mediate tramtrack's function during Drosophila tracheal system development / Identificación y análisis funcional de nuevos factores que median la función de tramtrack durante el desarrollo del sistema traqueal de Drosophila
A stereotyped tubular epithelial network forms many of our bodies’ organs and, defects in the formation of these tubules often leads to organ failure. My Thesis project aims to further understand the mechanisms underling ...
Identification and functional characterization of genetic loci involved in osteoporosis and atypical femoral fracture
Osteoporosis is a complex disease, determined by genetic and environmental factors, characterized by a low bone mass and microarchitectural deterioration of bone tissue, with a consequent decrease of bone strength and ...
Identification and functional characterization of P1N-PISPO, a new gene product present in sweet potato potyviruses
Sweet potato feathery mottle virus (SPFMV) (Potyvirus genus, Potyviridae family) causes important yield losses in sweet potato crops, in particular in co-infections with the unrelated crinivirus Sweet potato chlorotic stunt ...
Identification and partial characterization of acid phosphatases from Haemophilus parasuis
Haemophilus parasuis es una bacteria Gram negativa común en el tracto respiratorio superior de cerdos sanos y es el agente etiológico de la enfermedad de Glässer, que se caracteriza por poliserositis fibrinosa y poliartritis. ...
Identification and phylogeny of clinical and environmental isolates of Alternaria, Cladosporium and other genera of dematiaceous hyphomycetes
La present tesi s’ha centrat en l’estudi de la diversitat d’espècies i la taxonomia dels gèneres Alternaria i Cladosporium, així com d’altres gèneres d’hifomicets dematiàcis morfològicament similars. S’han estudiat un total ...
Identification and validation of phenotypes in a cohort of patients with obstructive sleep apnea
Introducció. L'apnea obstructiva del son (AOS) és una malaltia heterogènia, complexa, que s'associa a múltiples comorbiditats. L'objectiu d'aquest estudi és identificar fenotips d'AOS mitjançant una anàlisi de clúster, fer ...
Identification by virtual screening of protein tyrosine phosphatase 1B and matrix metalloproteinase 13 inhibitors for the treatment of obesity and obesity-associated disorders
L'obesitat és un dels principals problemes de salut pública del segle XXI. La gran expansió econòmica de les últimes dècades en els països desenvolupats ha contribuit a l’increment del consum d’aliments poc saludables i a ...
Identification de facteurs d'intégration quantitatifs et qualitatifs des néologismes à la langue spécialisée médicale: une analyse sur corpus diachronique entre 2007 et 2015
La evolución del lenguaje médico refleja los avances médicos y se caracteriza por la creación neológica destinada a nombrar nuevos descubrimientos e innovaciones. Por lo tanto, la creación neológica, la variación terminológica ...
Identification of a new deadenylation negative feedback loop that regulates meiotic progression
Els oòcits de vertebrats es troben aturats a la profase I de la primera meiosi (PI). Durant el procés anomenat oogènesi, els oòctits sintetitzen i emmagatzemen grans quantitats d'ARN missatgers(ARNm)que els seran necessaris ...
Identification of a risk transcriptome and proteome in Parkinson’s disease, Dementia with Lewy bodies and rapidly progressive Dementia with Lewy bodies
Parkinson's disease (PD) is a neurodegenerative disorder characterized by movement impairment, or parkinsonism, for which there is still no cure. The manifest clinical signs result from neuronal loss of more ...
Identification of altered regulatory interactions in disease
Gene regulation is a complex biological process that requires the coordinated interaction of different molecules. The integrity of the underlying mechanisms ensures the correct expression of genes that maintain cell ...
Identification of black carbon contributions in oceanic sediments using benzene polycarboxylic acid markers
El carboni negre (BC) abasta una àmplia gamma de materials orgànics derivats de la combustió que són químicament i estructuralment heterogenis. Constitueix una fracció significativa de la matèria orgànica acumulada als ...
Identification of clinically relevant genetic variation in immune-mediated inflammatory diseases using genome-wide approaches
Rheumatoid arthritis, psoriasis, psoriatic arthritis, systemic lupus erythematosus, Crohn’s disease and ulcerative colitis are six of the most prevalent immune-mediated inflammatory diseases (IMIDs) and are associated with ...
