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Mostrando ítems 41538-41557 de 42829
Unraveling the molecular mechanisms involved in RCAN-peptide mediated inhibition of calcineurin-NFAT signaling and its potential as an inhibitor of tumor progressions
The calcineurin-NFATc signaling pathway is involved in many aspects of the development and function of the immune, neural, skeletal, cardiovascular and muscular system of vertebrates. Regulators of Calcineurin (RCAN) ...
Unraveling the success of invaders: biotic and abiotic factors determining the invasibility of Mediterranean benthic assemblages by Caulerpa cylindracea
Biological invasions have become one of the most pervasive threats to native ecosystems worldwide, causing species extinctions, disrupting the functioning of ecosystems, altering the provision of critical ecosystem services ...
Unravelling 3D cargo transport dynamics at the microtubule network with super-resolution microscopy
Intracellular transport plays an essential role in a wide variety of fundamental cellular processes required to maintain the internal regulation and organization of cells. Different types of cargos such as organelles, ...
Unravelling cell-particle interactions for the design of new micro- and nanoengineered systems
Els micromaterials i nanomaterials presenten unes propietats fisicoquímiques úniques i controlables, les quals han permès la creació d’eines innovadores per tal d’afrontar alguns dels reptes que presenten diferents branques ...
Unravelling genetic predisposition to familial breast and ovarian cancer: new susceptibility genes and variant interpretation by in silico approaches
Patients with hereditary breast and ovarian cancer (HBOC) in whom a causative pathogenic variant is not identified after genetic analysis may not benefit from prevention, early detection, or precision treatment measures. ...
Unravelling herbicide resistance in corn poppy (Papaver rhoeas L.) to improve integrated weed management strategies
La presencia de biotipos de amapola (Papaver rhoeas L.) resistentes a herbicidas constituye uno de los principales problemas de muchas áreas cerealistas de secano. La solución del mismo pasa por una correcta caracterización ...
Unravelling integrated kinetics during spindle assembly
To ensure faithful segregation of the genetic material, during mitosis the cell assembles the mitotic spindle, a macromolecular machine made of dynamic microtubules and associated proteins. Spindle microtubules are assembled ...
Unravelling mechanistic underpinnings of organometallic nickel chemistry and applications into medicinal chemistry
El níquel, degut a les seves propietats químiques inherents, ofereix patrons de reactivitat versàtils alhora que és abundant a la Terra i més assequible que altres metalls nobles com el pal·ladi o el ròdium. A més, la ...
Unravelling motor protein organization on lysosomal membranes with super-resolution microscopy
This thesis first develops new methods for high-throughput and multi-color super-resolution microscopy (Chapters 2 and 3). Subsequently, I apply these methods to study the organization of motor proteins on the lysosome ...
Unravelling new oncogenic functions of IKKα : towards a better understanding of colorectal carcinogenesis
Numerous studies have shown that the protein kinase IKKα is associated with cancer progression and metastasis in different models. However, the mechanisms underlying IKKα tumorigenic functions are poorly understood. We ...
Unravelling seabird-fishery dynamics through bird-borne technologies
[eng] Seabirds and fisheries share the same fishing resources and grounds, resulting in their inevitable interaction, with significant conservation implications for the firsts. Seabirds scavenging on fishery waste modify ...
Unravelling the (micro)plastic threat: the case study of plastic ingestion in Aristeus antennatus and Nephrops norvegicus from the NW Mediterranean Sea and its potential impact on health condition
L’impacte de la contaminació per plàstics, especialment en forma de microplàstics, ha copsat l’atenció dels mitjans durant les últimes dècades. La seva distribució generalitzada i la facilitat per interaccionar amb multitud ...
Unravelling the epigenomic, transcriptomic and cognitive interplay in Down syndrome
The presence of an extra copy of Human Chromosome 21 (HSA21) in Down syndrome (DS) is one of the most complex genetic perturbations compatible with life and is the most common genetic cause of intellectual disability. Here, ...
Unravelling the molecular bases of carotenoid biosynthesis in maize
My research program focused on the elucidation of the mechanisms of carotenoid accumulation in maize (Zea mays). I amplified a putative carotenoid ε-hydroxylase, named CYP97C19, from the yellow maize variety B73. Metabolic ...
Unravelling the molecular complexities of early-stage oestrogen receptor positive breast cancer to identify biomarkers of resistance to endocrine therapy
[eng] 80% of breast cancer (BC) express positive estrogen receptors (ER+) and up to 15% of them also overexpress or amplify the human epidermal growth factor receptor 2 (HER2), which confers a molecular biology and different ...
Unravelling the pathobiological diversity of highly pathogenic avian influenza in birds
La influença aviària (IA) es considera una de les malalties virals més importants que afecten la indústria avícola i una amenaça contínua per a la població humana i la vida salvatge. Fins a la data, no hi ha una comparació ...
Unravelling the pluripotency state of human embryonic stem cells derived from single blastomeres of 8-cell embryos
Les cèl·lules mare embrionàries (ESCs) poden presentar almenys dos estats de pluripotència: naïve i primed, amb un perfil d’expressió gènica semblant al de l’epiblast preimplantacional i postimplantacional, respectivament. ...
Unravelling the positional behaviour of fossil hominoids: Morphofunctional and structural analysis of the primate hindlimb
Los hominoideos actuales (simios y humanos) son primates ortógrados con comportamientos locomotores especializados como la suspensión, la escalada vertical y el bipedismo. En este sentido, identificar aquellas adaptaciones ...
Unravelling the Role of Long Noncoding RNAs in the Context of Cell-growth and Regeneration
Long noncoding RNAs (lncRNAs) have proven biological roles in plethora cellular contexts. Nonetheless, only a handful have been clearly characterized, leaving thousands of newly discovered lncRNAs without an associated ...
Unravelling the role of the cerebellum in drug addiction. Cerebellum-prefrontal networks in drug-induced preference memory
This doctoral thesis is the first to propose a causative working model for the cerebellum's role in drug-induced memories. We managed to explore the role of the cerebellum in cocaine-induced conditioned preference and its ...
