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Molecular insights on arrhythmogenic cardiomyopathy: assessment of premature termination codons in desmosomal genes and variants reclassification
Arrhythmogenic cardiomyopathy (ACM) is an entity that groups different clinical forms of hereditable cardiac diseases that are associated to ventricular arrhythmia and sudden cardiac death. The main cases are characterized ...
Molecular keys in structural evolution of insect ovaries
The present work aims at establishing the first bases for studying the insect oocyte polarity in a phylogenetically basal species, the cockroach Blattella germanica. Our approach was to choose some genes that have been ...
Molecular mechanism of dBigH1 action
INTRODUCTION: For decades it was known that many species contain embryo specific linker histone H1 variants that replace the somatic H1 during early embryogenesis. This is especially important because the early embryo ...
Molecular mechanism of PE5-induced cytotoxicity and generation of new cytotoxic nuclear-directed
Cytotoxic ribonucleases are promising agents to be used in the treatment of cancer. Our group previously described a cytotoxic human pancreatic ribonuclease variant, named PE5, which carries a nuclear localization signal. ...
Molecular mechanisms and effect of acute and psychosocial stress on the intestinal barrier function. Implications on the irritable bowel syndrome
El estrés psicosocial es uno de los grandes problemas de salud en las sociedades modernas. En condiciones fisiológicas el estrés representa una amenaza para la homeostasis. En respuesta al estrés se genera una respuesta ...
molecular mechanisms controlling the diurnal oscillation of r-loop formation in arabidopsis thaliana
El rellotge circadiari és un mecanisme cel·lular endogen que sincronitza processos biològics en coordinació amb els cicles de 24 hores del dia i la nit. La funció circadiària és essencial per a la regulació rítmica de ...
Molecular mechanisms during the differentiation, maturation and function of marine fish spermatozoa
The molecular mechanisms regulating sperm differentiation (spermiogenesis) and maturation in fishes are largely unknown. In these oviparous species, the initiation of sperm motility is triggered by the osmolality of the ...
Molecular mechanisms for active DNA demethylation in cellular immune models
Epigenetic factors, such as histone post-translational modifications and DNA methylation, are critical determinants of gene expression, which ultimately defines cell identity and function. Despite intense research in DNA ...
Molecular mechanisms involved in Platinum-Induced Peripheral Neuropathy. An exploratory study
La neuropatia perifèrica induïda per platins (NPIP) és un dels efectes adversos més freqüents del cisplatí, l’oxaliplatí i el carboplatí, agents quimioteràpics de tipus platins administrats pel tractament de càncers altament ...
Molecular mechanisms involved in the cerebral cortex development and their implications in neurodevelopmental disorders
During the process of corticogenesis, cortical radial glial cells (RGs) generate sequentially most of the distinct types of neurons and glial cells that will populate the neocortex. The generation of these cells at the ...
Molecular mechanisms involved in the immunomodulation induced by LIF in cancer
LIF is a pleiotropic cytokine that can act as an immunomodulatory factor in different biological processes, such as embryo implantation, organ transplantation tolerance and multiple sclerosis. Here, we have observed that ...
Molecular mechanisms involved in the process of muscle wasting : human and animal studies
Muscle dysfunction and muscle wasting are major systemic manifestations of chronic conditions such as Chronic Obstructive Pulmonary Disease (COPD) and cancer. Several biological mechanisms contribute to such a dysfunction. ...
Molecular mechanisms involved in the protective effect of Mediterranean diet and olive oil consumption in humans
The scope of the present work was to investigate whether the protective role of the traditional Mediterranean diet (TMD), and virgin olive oil (VOO) rich in phenolic compounds (PC), towards cardiovascular disease can be ...
Molecular mechanisms of ageing in neurodegeneration role of oxidative and endoplamic reticulum stress in different human diseases
La hipòtesi de treball d'aquesta tesi es que les malalties neurodegeneratives<br/>poden considerarse formes accelerades de l'envelliment, selectives per a<br/>determinades localitzacions anatòmiques del teixit nerviós. ...
Molecular mechanisms of alternative splicing regulation by antitumor drugs targeting U2 snRNP
RNA splicing is the process of removal of introns from pre-mRNAs. It is carried out by the spliceosome, composed of five small nuclear ribonucleoproteins (snRNPs). Several small molecules with antitumor properties target ...
Molecular mechanisms of apoptosis induced by dexamethasone in chronic lymphocytic leukemia
Glucocorticoids are frequently included in the chemotherapy regimens administered to patients with CLL because they are potent immunosuppressant agents and because they are able to induce apoptosis in CLL cells. Although ...
Molecular mechanisms of apoptosis induction by AICAR and the new prohibitin-binding compound fluorizoline
The pro-apoptotic effects of two new drugs have been studied for the development of new strategies for cancer treatment. On the one hand, we proved that AICAR induces apoptosis in an AMPK- and p53-independent manner in ...
Molecular mechanisms of msl2 mRNA translational regulation
Regulation of msl2 translation is a key step in the modulation of X-chromosome dosage compensation. MSL2 is the limiting subunit of the dosage compensation complex, an assembly that promotes hyper-transcription of the ...
Molecular mechanisms of plastidial differentiation
Los carotenoides son isoprenoides que tanto los organismos fotosintéticos como algunos no fotosintéticos producen. Tienen funciones relacionadas con la fotosínte sis, la fotoprotección, la señalización y la pigmentación. ...
Molecular mechanisms of resistance to PI3K inhibitors
The development of high-throughput sequencing technologies has prompted the evaluation of large cohorts of different tumor types. The results from these comprehensive genomic studies have revealed the most commonly mutated ...
