Now showing items 29786-29805 of 43181
Pigrau Pastor, Marc (Date of defense: 2018-11-28)
El estrés psicosocial es uno de los grandes problemas de salud en las sociedades modernas. En condiciones fisiológicas el estrés representa una amenaza para la homeostasis. En respuesta al estrés se genera una respuesta ...
Zhou, Wenguan (Date of defense: 2024-07-24)
El rellotge circadiari és un mecanisme cel·lular endogen que sincronitza processos biològics en coordinació amb els cicles de 24 hores del dia i la nit. La funció circadiària és essencial per a la regulació rítmica de ...
Castro Arnau, Júlia (Date of defense: 2023-10-23)
The molecular mechanisms regulating sperm differentiation (spermiogenesis) and maturation in fishes are largely unknown. In these oviparous species, the initiation of sperm motility is triggered by the osmolality of the ...
Català Moll, Francisco (Date of defense: 2020-06-08)
Epigenetic factors, such as histone post-translational modifications and DNA methylation, are critical determinants of gene expression, which ultimately defines cell identity and function. Despite intense research in DNA ...
Calls Cobos, Aina (Date of defense: 2021-06-29)
La neuropatia perifèrica induïda per platins (NPIP) és un dels efectes adversos més freqüents del cisplatí, l’oxaliplatí i el carboplatí, agents quimioteràpics de tipus platins administrats pel tractament de càncers altament ...
Pijuán Jiménez, Isabel (Date of defense: 2019-12-02)
During the process of corticogenesis, cortical radial glial cells (RGs) generate sequentially most of the distinct types of neurons and glial cells that will populate the neocortex. The generation of these cells at the ...
Sala Hojman, Ada (Date of defense: 2016-07-15)
LIF is a pleiotropic cytokine that can act as an immunomodulatory factor in different biological processes, such as embryo implantation, organ transplantation tolerance and multiple sclerosis. Here, we have observed that ...
Fermoselle Pérez, Clara (Date of defense: 2012-11-26)
Muscle dysfunction and muscle wasting are major systemic manifestations of chronic conditions such as Chronic Obstructive Pulmonary Disease (COPD) and cancer. Several biological mechanisms contribute to such a dysfunction. ...
Konstantinidou, Valentini (Date of defense: 2010-03-22)
The scope of the present work was to investigate whether the protective role of the traditional Mediterranean diet (TMD), and virgin olive oil (VOO) rich in phenolic compounds (PC), towards cardiovascular disease can be ...
Vasileva Ilieva, Ekaterina (Date of defense: 2009-05-12)
La hipòtesi de treball d'aquesta tesi es que les malalties neurodegeneratives<br/>poden considerarse formes accelerades de l'envelliment, selectives per a<br/>determinades localitzacions anatòmiques del teixit nerviós. ...
Vigevani, Luisa (Date of defense: 2016-11-21)
RNA splicing is the process of removal of introns from pre-mRNAs. It is carried out by the spliceosome, composed of five small nuclear ribonucleoproteins (snRNPs). Several small molecules with antitumor properties target ...
Gomes Monteiro Lopes Baptista, Maria João (Date of defense: 2012-10-10)
Glucocorticoids are frequently included in the chemotherapy regimens administered to patients with CLL because they are potent immunosuppressant agents and because they are able to induce apoptosis in CLL cells. Although ...
Moncunill Massaguer, Cristina (Date of defense: 2015-07-23)
The pro-apoptotic effects of two new drugs have been studied for the development of new strategies for cancer treatment. On the one hand, we proved that AICAR induces apoptosis in an AMPK- and p53-independent manner in ...
García Beyaert, Marina (Date of defense: 2016-01-27)
Regulation of msl2 translation is a key step in the modulation of X-chromosome dosage compensation. MSL2 is the limiting subunit of the dosage compensation complex, an assembly that promotes hyper-transcription of the ...
Torres Montilla, Salvador (Date of defense: 2022-02-25)
Los carotenoides son isoprenoides que tanto los organismos fotosintéticos como algunos no fotosintéticos producen. Tienen funciones relacionadas con la fotosínte sis, la fotoprotección, la señalización y la pigmentación. ...
Castel Morales, Pau (Date of defense: 2016-05-09)
The development of high-throughput sequencing technologies has prompted the evaluation of large cohorts of different tumor types. The results from these comprehensive genomic studies have revealed the most commonly mutated ...
Pedrosa, Leire (Date of defense: 2020-10-30)
[cat] El glioblastoma (GBM) és el tumor primari cerebral més freqüent i més agressiu. Els pacients amb GBM tenen una supervivència mitjana de 15 mesos. Una dels principals dificultats que presenten els GBMs per ser tractats ...
Solé-Soler, Roger (Date of defense: 2023-12-04)
Els cromosomes han de ser manipulats amb compte per mantenir la integritat del genoma. La família de complexos proteics SMC contribueix a organitzar el genoma en llaços de cromatina, utilitzant la seva activitat d'ATPasa ...
del Ser Badia, Anna (Date of defense: 2022-11-11)
La remodelació sinàptica depenent d’activitat o plasticitat sinàptica és considerada la base cel·lular de diferents processos fisiològics cerebrals com l’aprenentatge i la memòria. Un proteoma equilibrat és essencial per ...
Gamez Molina, Beatriz (Date of defense: 2015-12-17)
We propose a molecular description of the mechanism whereby the osteogenic master gene Osx is controlled post-transcriptionally through a mechanism driven by miR-322/Tob2, strongly suggesting that control of specific mRNA ...