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Role of inflammation and oxidative stress in the systemic manifestations of chronic respiratory diseases: lung cancer, chronic obstructive pulmonary disease, and bronchiectasis
Introducció: Les malalties respiratòries cròniques com el càncer de pulmó (CP), la malaltia pulmonar obstructiva crònica (MPOC) i les bronquiectàsies afecten tant les estructures pulmonars com els òrgans fora del sistema ...
The role of information and telecommunication technologies in the productivity of Central and Eastern European countries
La tesi està escrita com un manuscrit de cinc publicacions científiques i presenta una de les primeres evidències de la relació entre les tecnologies de la informació i la comunicació (TIC) i la productivitat en els països ...
Role of Interstitial Cells of Cajal in the Pacemaker Activity and Neurotransmission in the Rat Colon
Els objectius d'aquesta tesi han estat l'estudi de la funció de les cèl·lules intersticials de Cajal (ICCs) en l'activitat marcapassos i en la transmissió neuromuscular, dins el tracte gastrointestinal. L'estudi s'ha ...
Role of intra-abdominal hypertension in the development and outcome of ovarian hyperstimulation syndrome
[spa] INTRODUCCIÓN: El síndrome de hiperestimulación ovárica (SHO) es la complicación yatrogénica más grave y potencialmente mortal asociada con las técnicas de reproducción asistida (TRA). El SHO moderado o grave puede ...
The Role of intracellular amyloid β-peptide in the pathophysiology of GNE myopathy and Alzheimer's disease
The Amyloid β-peptide (Aβ) is accumulated in several diseases including GNE myopathy and Alzheimer’s disease (AD). GNE myopathy is a skeletal muscle disorder caused by biallelic mutations in the UDP-N-acetylglucosamine ...
Role of iron content and endostatin expression in the progression of diabetic retinopathy
La retinopatia diabètica és la principal causa de ceguera en la població adulta i s’espera que la seva prevalença continuï augmentant en els propers anys. Està dividida en una fase no proliferativa, en la que es donen ...
Role of KCN E4 on the voltage gated potassium channel Kv1.3 = Paper de KCNE4 en el canal de potassi dependent de voltage Kv1.3
Voltage gated potassium channels (Kv) play important roles in different biological process such as generation and propagation of the nerve pulse and the cardiac action potential, promotion of insulin secretion, cell volume ...
Role of kinase DYRK1A in the neurogenesis of the embryonic telencephalon
[eng] DYRK1A is a kinase that is expressed in virtually all tissues and cell types and is implicated in human diseases. Several studies indicate that DYRK1A is a dose-dependent gene with a prevalent function in brain ...
The Role of Kindlin-2 in the progression of renal fibrosis
Chronic kidney disease (CKD) is usually characterized by histological lesions of glomerulosclerosis and tubulointerstitial fibrosis (TIF). The progressive TIF is mediated by multiple mediators such as growth factors, ...
The role of landscape and species attributes in insect community assembly, population genetics and plant-insect interactions in expanding Quercus ilex forests
Los mecanismos responsables de la colonización y coexistencia de las especies en los hábitats, es uno de los mayores rompecabezas en ecología de comunidades. Varias teorías, entre ellas la teoría de nicho, neutral y de ...
The Role of leaders' characteristics on governments formation
This Ph.D. dissertation examines the extent to which the personal characteristics of political leaders affect their political ambition and government formation processes. While the literature shows that government ...
The role of learning in asset pricing
Hi ha algunes dades interessants o anomalies en els mercats d'actius, i aquesta tesi utilitza enfocament d'aprenentatge "racionalitat interna" per explicar aquests fets. El primer capitol primer determina que el moviment ...
Role of linker Histone H1 variants in cell proliferation, Chromatin Structure and Gene expression in breast cancer cells
At least eleven histone H1 variants exist in mammalian somatic cells that bind to the linker DNA and stabilize the nucleosome particle contributing to higher order chromatin compaction. In addition of playing a structural ...
The role of lung ultrasonography in the evaluation of neonatal respiratory distress syndrome
Objetivo de nuestro estudio fue evaluar la capacidad diagnóstica de la ecografía pulmonar en el diagnóstico del Síndrome del Distrés Respiratorio (SDR), así como en el seguimiento de la respuesta al tratamiento. La ecografía ...
Role of lysophosphatidic acid receptors in spinal cord injury physiopathology
La médula espinal, la cual constituye una parte vital para el sistema nervioso central (SNC), puede resultar dañada a pesar de estar muy bien protegida por la columna vertebral, dando lugar a importantes consecuencias. La ...
The Role of macroH2A1 histone variant in muscle metabolism and development
In the eukaryotic nucleus, DNA, wrapped around a core of histone proteins. Replication-coupled histones can be exchanged by histone variants. In mammals, H2A can be replaced by three distinct macroH2A proteins. Alternative ...
Role of MAF in bone metastasis
The identification of genes that mediate metastasis is pivotal to better understand the mechanism, to develop novel drugs and to stratify patients with highest risk and consecutively administrate them preventive treatments. ...
The role of mesenchymal stem cell products in experimental asthma
L’asma es una malaltia inflamatòria crònica que afecta aproximadament a 300 milions de persones en tot el mon. Aquesta malaltia es caracteritza principalment per un conjunt d’alteracions estructurals en les vies respiratòries, ...
Role of Methylation in Modulating MAPK Signaling. Implications in Melanoma. Papel de la metilación como modulador de la señalización en MAPK. Implicaciones en melanoma.
1. General Overview MTAP is a key enzyme in the methionine salvage pathway and controls the levels of methylthioadenosine (MTA). Lost of MTAP, which is frequent in melanoma, results in higher intra and extracellular MTA ...
Role of Mfn2 in Macrophage Inflammatory Responses
Mitochondria are well known for their role as bioenergetic and biosynthetic organelles. Recently, they also have emerged as one of the main regulators of innate immune responses, mostly for its ability to modulate several ...
