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Now showing items 35642-35661 of 41827
Role of the histone demethylase PHF2 during early neurogenesis
During neural development, signaling molecules and networks of expressed transcription factors cooperate to control cellular fate. Chromatin acting factors are essential players in cell proliferation and differentiation ...
The role of the histone variant macroH2A in the regulation of chromatin architecture
In the eukaryotic cell nucleus, DNA is tightly wrapped around histone complexes, forming a dynamic structure known as chromatin. The nucleosome particle is the basic repeating unit of the chromatin fiber and its protein ...
Role of the human Concentrative Nucleoside Transporter 1 (hCNT1) in oncogenesis
Transportome alterations have been associated with oncogenesis. The loss of human Concentrative Nucleoside Transporter 1 (hCNT1) during carcinogenesis seems to be a relatively common event in tumors and might by itself ...
The role of the husking trays in the late neolithic communities of the near east
El paper dels Husking trays a les comunitats del Neolític final del Pròxim Orient. Aquest projecte de recerca es centra en entendre millor el paper d’una de les formes de ceràmica que més van caracteritzar el Neolític final ...
Role Of The Innate Immunity In The Etiopathogenesis of Primary Sjögren Syndrome: Influence Of Viral And Immunogenetic Factors Related To Cell Adhesion Molecules In Systemic Disease And Autoantibody Profile
[eng] Sjögren Syndrome is a systemic autoimmune disease that affects the exocrine glands, most notably the salivary and lacrimal glands, although it can affect other mucosal surfaces. Inflammation at these sites leads to ...
Role of the Intestinal Microbiota and metabolomic profile in Type 2 Diabetes: effects on risk factors for comorbidities associated with this pathology and insulin resistance of specific organs and tissues
Antecedents: La diabetis de tipus 2 (DM2) es considera una creixent epidèmia mundial, associada a diverses comorbiditats, que inclouen les malalties cardiovasculars, malalties del fetge o demències, generant un nombre ...
Role of the kidney androgen-regulated protein in the development of the metabolic syndrome
El síndrome metabólico (SM) incluye síntomas tales como la obesidad, la resistencia a la insulina, hiperinsulinemia compensatoria, dislipidemia (DLP) y la hipertensión arterial (HTA) en conjunto que lleva a la diabetes ...
Role of the Kinases NEK6, NEK7 and NEK9 in the Regulation of the Centrosome Cycle
This thesis project is focused on the study of the signaling module formed by the NIMA-related protein Nek6, Nek7, and Nek9 and their function during early mitosis, with particular interest in centrosome separation and ...
Role of the LILRB1 HLA class I-specific inhibitory receptor in the regulation of macrophage function
In the present work the regulatory role played by the HLA class I (HLA-I)-specific LILRB1 inhibitory receptor in human macrophages (MΦ) was addressed. In vitro differentiated monocyte-derived M1 and M2 MΦ expressed different ...
The Role of the Local Community Participation in the Management of Cultural Heritage: A Case Study of Rijal Almaa and Historical Example in Rural Saudi Arabia
Amb l’ampli enfocament en l’àmbit del patrimoni cultural a l’Aràbia Saudita durant les últimes dècades, també hi ha hagut un desenvolupament accelerat des del punt de vista institucional i acadèmic. Atès que la gestió del ...
Role of the MAP kinase Sty1 and the transcription factor Atf1 in euchromatin and heterochromatin dynamics in Schizosaccharomyces pombe
Eukaryotic DNA is condensed inside the nucleus, compacted into chromatin. The structure of chromatin is dynamic, and its accessibility to cellular machinery can be altered depending on the level of chromatin compaction ...
Role of the metacaspase AtMC1 in stress-triggered protein aggregate formation in yeast and plants
L’agregació de proteïnes és un fenomen generalitzat a les cèl·lules que es pot associar a condicions patològiques. La formació d’agregats de proteïnes és induïda per múltiples tipus d’estrès, inclosos temperatura, químic, ...
Role of the NADPH oxidase NOX4 in hepatocyte proliferation
[spa] La familia de las NADPH oxidasas ha emergido en los últimos años como una importante fuente de producción de radicales libres de oxígeno (ROS), los cuáles juegan un papel fundamental en situaciones fisiológicas y ...
Role of the NADPH Oxidase NOX4 in Liver Fibrosis and Hepatocarcinogenesis
Reactive oxygen species (ROS) are short-lived, highly electrophilic molecules generated by the partial reduction of oxygen to form superoxide, hydrogen peroxide and hydroxyl radical as well as other secondary metabolites. ...
The role of the oncogene prostate tumor overexpressed-1 and the regulation of mRNA translation in prostate cancer progression and chemoresistance
El cáncer de próstata (CaP) metastásico es actualmente incurable. Prostate tumor overexpressed 1 (PTOV1) se expresa a niveles altos en CaP y otras neoplasias asociado a estadíos más agresivos y mal pronóstico clínico. Un ...
Role of the protein quality control system in basal and stress conditions in fission yeast
Proteostasis is the proper homeostasis of the concentration and the molecular structure of the proteins, which preserves the integrity of the proteome. Proteo-stasis is constantly challenged by intrinsic and extrinsic ...
Role of the RecA protein in the structuration and function of Salmonella enterica chemotaxis signalling complexes
Salmonella enterica és un patogen entèric primari que infecta tant humans com animals i és la causa més freqüent de malalties transmeses per aliments. S. enterica es pot propagar a les persones a través d'aliments contaminats ...
Role of the regulation of cell lipid composition and membrane structure in the antitumor effect of 2-hydroxyoleic acid
El ácido 2-hidroxioleico (2OHOA) es un fármaco antitumoral diseñado para regular la estructura y composición de los lípidos de membrana y la función de importantes proteínas de membrana. El objetivo principal de este trabajo ...
Role of the sigma-1 receptor in the pathophysiology of osteoarthritis pain
Osteoarthritis is the most common musculoskeletal disease worldwide, characterized by degradation of the articular cartilage, chronic joint pain and disability. Currently available treatments for osteoarthritis have limited ...
Role of the sigma-1 receptor in the sensory-discriminative and affective-motivational components of acute and chronic pain
The present Doctoral Thesis focuses on the study of the sigma-1 receptor (σ1R) in the field of pain. This research has been a part of the preclinical σ1R project focusing on drug discovery of σ1R ligands for the treatment ...
