Universitat de Barcelona
Mostrando ítems 5307-5326 de 11185
Metastatic breast cancer (BCa) is the leading cause of death in BCa patients. Current therapies for BCa aim at cell proliferation and, therefore, latent disseminated cells are able to escape treatment. For this reason, ...
The present thesis has established a new and state of the art mammalian protein expression system at the laboratory which has then contributed with high-yield expression for the purification and crystallization of three ...
The work developed during this PhD has embraced several topics that I divide in three blocks. Each block contains two chapters in this dissertation. Additionally, a general introduction of the different topics is provided ...
Major dynamical traits of a neuronal network are shaped by its underlying circuitry. In several neurological disorders, the deterioration of brain's functionality and cognition has been ascribed to changes in the topological ...
After germination in darkness, Arabidopsis seedlings follow a dark specific developmental pattern called skotomorphogenesis or etiolation, characterized because the plant develops long hypocotyls together with a closed ...
Plasma Polymerization is a novel technique for the preparation of polymer-like thin film coatings at low temperatures onto almost any type of substrates: plastic, metal, semiconductors, wood, textile fibers or membranes, ...
Freshwater degradation has been largely attributed to excess nutrient concentrations of anthropogenic origin. Freshwater degradation in combination with water scarcity are the reason of severe stress on water resources ...
Macrophages require presence of M-CSF to survive and proliferate. Incubation of bone marrow macrophages with soluble factors (LPS or IFN-gamma) or insoluble factors such as extracellular matrix proteins (Decorin, FN) ...
Glucocorticoids (GC) induce cell cycle arrest and apoptosis in different cell types and therefore are widely used to treat a variety of diseases including autoimmune disorders and cancer. This effect is mediated by the GC ...
In this thesis, tumor metabolic reprogramming has been exploited in order to propose new targets in cancer treatment. On one hand, we explored the pentose phosphate pathway (PPP) enzymes as putative therapeutic targets ...
We identified proteins that interacted with the ectodomain of 4F2hc, a plasma membrane protein with dual function as heavy subunit of the amino acid transporters and positive regulator of β1 and β3 integrins. Initially, ...
Mitosis is a tightly regulated process that aims to ensure the correct distribution of the chromosomes between the two newly generated cells. Many protein kinases have been defined as essential for this process: cyclin- ...
The main subject of this PhD Thesis is the manufacturing of titanium dioxide multifunctional coatings by means of two spraying technologies: Cold Gas Spray (CGS) and Atmospheric Plasma Spray (APS). The characteristics of ...
The Cold Spray (CS) is a novelty technique for the production of coatings within the field of Thermal Spray. The use of low work temperatures (under the melting point of the material) is what makes it different from the ...
¿Cómo fundar regímenes políticos duraderos cuando resulta imposible encontrar un polo incondicionado desde el cual derivar la legitimidad de la ley? ¿Cómo establecerlos en las condiciones políticas de la modernidad, en una ...
En una serie de recientes trabajos, donde se estudian a fondo muchos problemas esenciales de la moderna teoría de las funciones de dos variables complejas, F. SEVERI ha establecido las bases de una fundamentación geométrica ...
[spa] La presente investigación pretende ocuparse de los fundamentos de la filosofía de la historia de Walter Benjamin a partir de una lectura pormenorizada de ciertos textos que consideramos esenciales. Estos fundamentos ...
El desarrollo sostenible (art. 2 Tratado de Ámsterdam de 1997) persigue la finalidad de la calidad de vida del ser humano (Preámbulo y art. 45.2 Constitución Española) en su dimensión intra e inter generacional. La ...
La importancia creciente que la incertidumbre tiene en economía no se ha visto correspondida por una atención suficiente a las cuestiones de fundamentación, desde el punto de vista conceptual, lógico y eidométrico. La tesis ...
