Universitat de Barcelona
Now showing items 1132-1151 of 11199
• L’anàlisi de la hipermetilació del promotor d’MLH1 utilitzant el mètode de l’MS-MLPA ha demostrat ser un mètode de selecció precís, i més rendible que l’estudi de la mutació BRAF en la selecció dels pacients que són ...
El càncer de pròstata es la segona causa de mort per càncer en els homes. Tot i que la majoria de pacients amb càncer de pròstata metastàtic responen al tractament de deprivació androgènica, tots ells acabaran desenvolupant ...
L'objectiu d'aquesta tesi ha estat caracteritzar el dany muscular induït per diversos exercicis del tren inferior mitjançant l'anàlisi de l'evolució temporal i la magnitud de canvi de l'activitat o la concentració de ...
The hypothesis of the present thesis is that the presence or absence of some chromatin factors may facilitate or impair the action of chemotherapeutic drugs in colorectal cancer (CRC). Chromatin factors have been proven ...
Infectious diseases are still one of the main leading causes of death worldwide mainly due the overuse and the lack of development of new antibiotics. This fact has increased the appearance of multidrug resistance (MDR) ...
Cognitive impairment in the elderly encompasses many forms, ranging from subtle impairments in otherwise cognitively healthy individuals through mild cognitive impairment and dementia. Brain structural and functional changes ...
There is a debate in the international literature between two differing conceptions of the Energy Transition: the so-cal led «energy ladder approach», according to which societies transit from qualitatively ...
[eng] Living tissues are active materials with the ability to undergo drastic shape and dimension transitions. If properly controlled, these morphological changes allow various physiological phenomena such as embryonic ...
This thesis is centered on the study of PolyPurine Reverse Hoogsteen (PPRH) hairpins technology as a tool for both gene silencing and gene editing. PolyPurine Reverse Hoogsteen (PPRH) hairpins are nonmodified single-stranded ...
Adenosine deaminase acting on transfer RNA (ADAT) is a human heterodimeric enzyme that catalyzes the deamination of adenosine (A) to inosine (I) at the first position of the anticodon of transfer RNAs (tRNAs) (position 34, ...
This research work was aimed at the characterization in vitro, ex vivo and in vivo of nanostructured systems which independently contain a natural flavanone extracted from Eysenhardtia platycarpa and another four flavanones ...
Advances in structural and molecular biology have increased the knowledge of relevant and undrugged targets and have favoured the rational development of novel drugs through structure- based drug design (SBDD). ...
In this thesis, single-molecule experiments using LOT are employed to extract accurate information about the thermodynamics and kinetics of various molecular systems, with special emphasis on the elastic properties of ...
Spinal bulbar muscular atrophy (SBMA) is a member of the polyglutamine (polyQ) expansion diseases family; the most famous of which is Huntington disease (HD). SBMA is caused by the expansion of the coding region for the ...
Once a target is identified and characterized, the long pathway to develop a drug starts. In this process, biophysical methods have an important part to play and nowadays are firmly combined at several stages. In this ...
Mining industry faces environmental problems concerning waste management. Given the environmental issues associated with storage of mine wastes on land, one disposal option that has gained attraction is submarine tailings ...
Els alquilbenzens lineals són els precursors per a la fabricació dels alquilbenzens lineals sulfonats, un dels principals surfactants aniònics per a usos domèstics i industrials. Aquest producte és una barreja de diversos ...
La presente tesis doctoral tiene como principal objetivo aportar conocimiento en el área de la biorremediación de suelos contaminados por hidrocarburos, mediante el estudio a escala real y de laboratorio de tratamientos ...
La aprobación sucesiva de normativas acerca de la contaminación de suelos (RD 9/2005) y los cambios en el uso del suelo, están aumentando la demanda en la descontaminación de suelos. Sin embargo, aún existen áreas necesitadas ...
Les plantes produeixen una gran varietat de compostos isoprenoides que són essencials tant pel seu creixement i desenvolupament com per la seva relació i adaptación amb l'entorn. La biosíntesi d'isoprenoides en plantes té ...
