Now showing items 5303-5322 of 11050

    Genetic Polymorphisms of RANK, RANKL and their relation to osteoporosis (Polimorfismos genéticos de RANK y RANKL y su relación con la osteoporosis) 

    Yoskovitz, Guy (Date of defense: 2012-12-05)

    Osteoporosis is a systemic skeletal disorder and the most common metabolic bone disease. It is recognized as one of the most prevalent problems facing postmenopausal women in western society. The World Health Organization ...

    Genetic Risk Factors for the Lack of Response to Clinical Treatment in Mental Disorders: an Approach from Pharmacogenetics 

    Mitjans Niubó, Marina (Date of defense: 2014-12-17)

    Severe mental disorders, such as Major Depressive Disorder (MDD), Bipolar Disorder (BD) and Schizophrenia (SCZ), represent a huge burden to society, reflecting the limited efficacy of current drug treatments. Although the ...

    Genetic risk factors in Schizophrenia and Neurodevelopmental disorders: Association and epistatic analyses of Neuritin-1 gene and white matter related genes = Factores genéticos en esquizofrenia y enfermedades del neurodesarrollo: análisis de asociación y epistáticos en el gen Neuritina-1 y en genes relacionados con la materia blanca 

    Prats Balado, Claudia (Date of defense: 2017-09-29)

    Nowadays, it is estimated that about 450 million people suffer from a mental or behavioural disorder in the world. According to World health organization (WHO), 33% of the years lived with disability (YLD) are due to ...

    Genetic variability and telomere length in bariatric surgery outcomes in obese patients 

    Peña Lozano, Elionora (Date of defense: 2020-11-13)

    Based on the background showing i) that obesity have a polygenic nature with the implication of different genes of minor effect and lifestyle factors; ii) the high variability between individuals in weight loss outcome ...

    Genetic variability of minnows and loaches in rivers and high mountain lakes from the Pyrenees and Italian Alps 

    Suh, Jongmo (Date of defense: 2024-02-20)

    [eng] The invasion of alien species is a major global threat to ecosystems, with significant impacts, especially on freshwater ecosystems. The species diversity in freshwater ecosystems has significantly declined worldwide, ...

    Genetic variation in serotonergic system genes: vulnerability for major depression and pharmacogenetics of response to SSRI antidepressants 

    Arias Sampériz, Bárbara (Date of defense: 2003-01-01)

    1. Objetivo General: Estudiar la variación existente en genes candidatos implicados en la neurotransmisión serotoninérgica como factor de riesgo en la depresión mayor y como factor relacionado con aspectos del fenotipo ...

    Genetic variation of the X chromosome and the genomic regions of Coagulation Factors VII and XII in human populations: Epidemiological and evolutionary considerations 

    Athanasiadis, Georgios (Date of defense: 2010-07-14)

    In this work we have analyzed the variation of (i) several X chromosome polymorphic Alu insertions and (ii) several SNPs and microsatellites within and around the genomic regions of the genes coding for coagulation factors ...

    Genetically Modified Macrophages and Renal Regeneration 

    Mastora, Chrysoula (Date of defense: 2013-12-10)

    After ischemic damage in kidney, alternatively activated or M2 macrophages are key players in resolving inflammation and participating in kidney repair. Obtaining this particular phenotype is a process controlled by ...

    Genetics and epigenetics of attention-deficit/hyperactivity disorder and comorbid conditions 

    Shivalikanjli, Anu (Date of defense: 2021-04-06)

    The broad objectives of this work are the identification of genes that contribute to the susceptibility to attention-deficit/hyperactivity disorder (ADHD) and cocaine dependence, two disorders that co-occur in patients. ...

    Genetics of human populations: evolutionary and epidemiological applications = Genética de las poblaciones humanas: aplicaciones evolutivas y epidemiológicas 

    Zanetti, Daniela (Date of defense: 2015-11-26)

    The present thesis deals with a deep analysis of the genetic structure of extant human worldwide populations, with a special focus on the Mediterranean. Different genetic markers, 18 Alu insertions and 367 single ...

    Genetics of natural variation and environmental modulation of immune-related hybrid incompatibilities in Arabidopsis 

    Atanasov, Kostadin Evgeniev (Date of defense: 2019-05-14)

    Arabidopsis thaliana is a small ruderal weed with prominent north-hemisphere distribution. It has an autogamous style of reproduction, whereas about 3% of the natural population can exhibit outcrosses. Some of these ...

    Genètica evolutiva en llagostes de l'infraordre Achelata / Evolutionary genetic of Achelata lobsters 

    Palero Pastor, Ferran (Date of defense: 2008-12-19)

    Aquesta tesi pretenia proporcionar noves perspectives sobre les relacions evolutives entre llagostes de l'infraordre Achelata utilitzant marcadors moleculars, tant d'evolució lenta com d'evolució ràpida, i calcular el temps ...

    Genètica i dependència de cocaïna: Estudis d'associació, transcriptòmica i models animals 

    Cabana Dominguez, Judit (Date of defense: 2018-10-05)

    La cocaïna és una droga psicoestimulant que actua directament sobre sistema de recompensa del cervell tot produint sensació de plaer. A més, els seus efectes sobre altres àrees cerebrals produeixen alteracions en l’estat ...

    Genètica i drogues psicoestimulants: dependència de cocaïna i consum d’èxtasi 

    Fernández Castillo, Noelia (Date of defense: 2011-05-27)

    La cocaïna i l’èxtasi (MDMA, 3,4-metilendioximetamfetamina) són drogues psicoestimulants que incrementen l’activitat del sistema nerviós central i perifèric amb efectes com l’augment de l’estat d’alerta, la resistència, ...

    Genètica i epigenètica de les addiccions i trastorns comòrbids 

    Pineda i Cirera, Laura (Date of defense: 2020-09-22)

    Aquesta Tesi té com a objectiu principal contribuir a l’estudi i a la identificació de factors genètics i epigenètics de susceptibilitat a les addiccions i a trastorns comòrbids, tant en humans com en models animals. Els ...

    Genètica molecular de l'autisme: recerca de variants de susceptibilitat i estudis funcionals 

    Torrico Aviles, Bàrbara (Date of defense: 2015-07-17)

    Els trastorns de l’espectre autista (TEA) són trastorns greus del neurodesenvolupament, caracteritzats per una discapacitat en la comunicació, tant verbal com no verbal, la limitació de la interacció social i comportaments ...

    Genética de la esclerosis múltiple: papel del HLA-DRB1 en la susceptibilidad y expresión fenotípica 

    Romero Pinel, Lucía María (Date of defense: 2010-11-03)

    La esclerosis múltiple (EM) es una enfermedad debida a factores genéticos y ambientales. Se ha demostrado que existe agregación familiar y que los genes del haplotipo HLA-DR2 son los que mayoritariamente se asocian con la ...

    Genoarquitectura del sistema nervioso durante el desarrollo embrionario del anfioxo: implicaciones evolutivas para el origen del cerebro de vertebrados 

    Albuixech Crespo, Beatriz (Date of defense: 2015-09-18)

    En esta tesis se ha estudiado en detalle la genoarquitectura de la placa neural del anfioxo en desarrollo. La expresión de varios genes había sido descrita en el primordio nerual del anfioxo, pero no existe ningún consenso ...

    A genome editing based approach to study tumor cell heterogeneity 

    Turón Rodrigo, Gemma (Date of defense: 2019-04-25)

    Colorectal tumors are not homogeneous entities but rather composed of a mixture of cells with different phenotypes, reminiscent of healthy intestinal epithelium cell types. Intestinal epithelium is one of the organs with ...

    Genome-wide transposon analyses: annotation, movement and impact on plant function and evolution 

    Hénaff, Elizabeth Marie (Date of defense: 2013-06-20)

    The diversity of life forms around us is astounding: a walk in the woods, or even down the street, shows us organisms of different morphologies: two legs, four legs, wings; different capacity of interaction with our ...