Angelats Canals, Edgar (Date of defense: 2018-09-14)
G-protein coupled receptors (GPCR) constitute a complex and versatile superfamily of membrane receptors with relevance in maintaining homeostasis. The thesis project has focused in members of this ...
Oliveras Martínez, Anna (Date of defense: 2015-12-18)
Voltage-gated K+ channels, Kv channels, are the most diverse group of K+ channels. They have several key functions in cardiovascular and nervous system; setting the resting membrane potential and ...
Aguilar Fadó, Esther (Date of defense: 2015-02-23)
Metastasis represents the most life-threatening aspect of tumorigenesis and is the leading cause of death by cancer. Intensive research in this field has shed light on some of the molecular strategies ...
Matito Sánchez, Cecilia (Date of defense: 2006-01-13)
Cancer is one of the leading causes of death in countries throughout the world. Increase in the production of Reactive Oxygen Species (ROS) has been implicated in many human disease processes, including ...
Hernaiz Llorens, Marc (Date of defense: 2019-11-25)
During brain development, UNC5 receptors play a key role in controlling axonal extension through their sensing of the guidance molecule Netrin-1. The correct positioning of receptors into specific ...
Obando Martínez, Ana Zuleima (Date of defense: 2016-05-19)
Heteromeric amino acid transporters (HATs) are the unique solute transporters known to be composed of two subunits linked by a disulphide bridge. The heavy subunit (4F2hc or rBAT), a type II membrane ...
Capera Aragonés, Jesusa (Date of defense: 2019-12-20)
Kv1.3 is a voltage-gated potassium channel mainly expressed at the plasma membrane and at the inner mitochondrial membrane of different cell types. A dual role for the channel has been suggested: Plasma ...
Ruiz Cánovas, Eugenia (Date of defense: 2018-12-10)
Compound F has been reported to possess important antioxidant, anti-inflammatory, anti- diabetic and anti-cancer effects, among other interesting properties. Although Compound F has been extensively ...
Henryka Gawrzak, Sylwia (Date of defense: 2016-11-23)
Breast cancer is the most frequently diagnosed cancer and remains the second leading cause of death among women in Europe and United States. In this malignancy, metastasis remains to be an incurable ...
López Fauqued, Marta (Date of defense: 2010-06-22)
Malignant melanoma is the most lethal skin cancer with no effective therapeutic treatment in its metastatic stages. RAS and PI3K pathways have been shown to play a critical role in melanoma development ...