Universitat Pompeu Fabra
Ara mostrant els elements 1373-1392 de 3286
Dsk2/UBQLN is a conserved extraproteasomal ubiquitin receptor that has been widely described as a protein involved in the ubiquitin proteasome pathway. In Drosophila, this protein has been recently reported in a non-proteolitic ...
MicroRNAs (miRNAs) are major contributors to phenotypic diversity and have a demonstrated role in evolution. We performed an analysis on how miRNA nucleotide substitutions may have contributed to human divergence from their ...
The focus of this work was to functionally characterize the CD300e receptor expressed in human monocytes and myeloid dendritic cells and investigate the implications that receptor engagement has on their biology. We provide ...
Compulsive, impulsive, and addictive disorders display some behavioral commonalities associated with a dysfunction in the regulation of motivated, goal-directed behavior. Relevant to motivated behavior, there is a set of ...
Alternative splicing (AS) is a post-transcriptional mechanism for gene expression regulation affecting almost every multiexonic gene in mammals. However, the impact of AS at the proteomic level remains under debate. In ...
The splicing regulatory protein RBM10 is frequently mutated in bladder carcinomas. Analysis of RNA sequencing data of 476 bladder tumours (UROMOL) identified 469 alternative splicing (AS) events associated with RBM10 ...
El complexos SWI/SNF són remodeladors de cromatina dependents d’ATP que es troben altament conservats al llarg de l’evolució. Aquests complexos poden regular l’accessibilitat a una zona genòmica alterant l’estat de la ...
En esta investigación doctoral se estudian los fundamentos y límites de la responsabilidad jurídico-penal del jefe o superior jerárquico de organizaciones delictivas por los delitos cometidos por sus subordinados. En ...
The purpose of this research is to elucidate the philosophical foundations of the Margin of Appreciation Doctrine of the European Court of Human Rights. For this, two basic problems are distinguished: the conceptual problem ...
Una adecuada interpretación del principio de legalidad ofrece buenas razones para admitir la analogía in bonam partem en el Derecho penal aunque de un modo limitado. Incluso cuando el juez mediante ésta excluye o limita ...
Esta tesis estudia el gag visual en tanto que imagen en movimiento, analizando sus formas, modelos y funciones esenciales. Se parte de una serie de ejemplos clave del cine mudo y el slapstick para rastrear su evolución ...
The focus of this dissertation is the globalized world of today. As a complex phenomenon, globalization has many and varied effects on our lives. Some of them are paradigmatically negative such as the impact on individual ...
El cuerpo principal de esta memoria de tesis doctoral se centra en las diferencias contables y fiscales en la regulación de los gastos fiscalmente deducibles en este Impuesto y, especialmente, de las amortizaciones y ...
Previous research has demonstrated the difficulty of the grammatical gender category for L2 learners and bilingual speakers. The main goal of this study is to investigate the gender agreement by 30 young L1 heritage speakers ...
Aquesta tesi avalua l'existència de diferencies per gènere en la relació entre discapacitat i mortalitat, i aspectes metodològics en l'anàlisi de supervivènciad'estudis de gent gran. Es van utilitzar les dades provinents ...
Esta tesis doctoral está basada en la identificación de las desigualdades de género en salud laboral descritas en la literatura científica, así como en el análisis de las desigualdades de género en la población ocupada en ...
Schizosaccharomyces pombe initiates sexual development under nitrogen starvation, changing the transcription patterns of many genes to allow sexual differentiation. MBF transcription factor recognize specific sequences ...
Mice are the premier model organisms to study human biology and disease, but there is still debate about the extent to which molecular mechanisms are conserved between human and mouse. With the advance of next-generation ...
This doctoral thesis aims to find a connection between two different disciplines. On the one hand, the electromagnetic theory, one of the most known and most applied theories in physics, properly described by the famous ...
Behind every good advertisement there is a creative concept, a Big Idea. In contrast to the countless number of ads, a small number of patterns of effective communication (idea templates) have been uncovered, which are ...
