Universitat Pompeu Fabra
Ara mostrant els elements 2621-2640 de 3239
Mi trabajo ha estado enfocado en la implicación de los diferentes mecanismos epigenéticos de PML-RARa en la inducción de la leucemia promielocítica aguda (APL).<br/>En particular yo estudié el rol de MBD1, un miembro de ...
Pancreatic ductal adenocarcinoma (PDA) is one of the most aggressive tumors; mostly due to its lack of symptoms, resulting in late diagnosis, and also due to the presence of an aggressive tumor microenvironment. Importantly, ...
This thesis is a compilation of three articles that aim to contribute to a deeper understanding of the role of higher education in refugees’ integration by focusing on urban refugees’ experiences who settled in a neighboring ...
Epigenetic modification serves as a crucial mechanism in regulating gene expression and facilitating cellular adaptation to environmental stress. This study aimed to identify histone residues and their associated ...
The relevance of epigenetics is increasingly recognized in haematopoietic diseases such as myelodysplastic syndromes (MDS) and acute myeloid leukaemia (AML). Variants of histones, such as macroH2As, and chromatin remodellers, ...
Polyomaviruses are suspected to cause cancer in humans although to date Merkel cell polyomavirus (MCPyV) is the only proven human carcinogen. Potential associations of up to nine polyomaviruses with 468 lymphoproliferative ...
The Amyloid β-peptide (Aβ) is accumulated in several diseases including GNE myopathy and Alzheimer’s disease (AD). GNE myopathy is a skeletal muscle disorder caused by biallelic mutations in the UDP-N-acetylglucosamine ...
Chronic kidney disease (CKD) is usually characterized by histological lesions of glomerulosclerosis and tubulointerstitial fibrosis (TIF). The progressive TIF is mediated by multiple mediators such as growth factors, ...
This Ph.D. dissertation examines the extent to which the personal characteristics of political leaders affect their political ambition and government formation processes. While the literature shows that government ...
At least eleven histone H1 variants exist in mammalian somatic cells that bind to the linker DNA and stabilize the nucleosome particle contributing to higher order chromatin compaction. In addition of playing a structural ...
In the eukaryotic nucleus, DNA, wrapped around a core of histone proteins. Replication-coupled histones can be exchanged by histone variants. In mammals, H2A can be replaced by three distinct macroH2A proteins. Alternative ...
Cardiovascular disease and, specifically, atherothrombosis is a global health problem with huge devastating consequences. While cardiovascular research has progressed rapidly over the last years, there is still a need ...
The marginal zone (MZ) of the spleen contains an innate-like subset of B cells that mount rapid protective antibody responses to polysaccharides and lipids from bloodborne viruses and bacteria. These antigens activate ...
Cells of our body are constantly exposed to events that can create lesions in the DNA. If unremoved by the DNA repair mechanisms, the lesion may lead to a mutational event. Some of these events might drive the transformation ...
The cell is governed by the complex interactions among various types of biomolecules. Coupled with environmental factors, variations in DNA can cause alterations in normal gene function and lead to a disease condition. ...
Macrophages are exquisite sensors of tissue homeostasis that can rapidly switch between pro- and anti-inflammatory or regulatory modes to respond to perturbations in the microenvironment. This functional plasticity involves ...
HER2 overexpression accounts for approximately 15-20% of breast tumors, and mainstay therapy for these patients includes HER2-specific antibodies in combination with chemotherapy. Although the efficacy of anti-HER2 antibodies ...
The correct development and function of CNS is critical for brain health of the organism. Early or chronic stress causes prominent alterations in brain function, and affects the expression of neurotrophic factors in limbic ...
Steroid receptors (SRs) are hormone-induced transcription factors that regulate gene expression by their concerted actions with coregulatory proteins. Performing a quantitative mass spectrometry-based interaction screen ...
Polycomb repressive complex (PRC) 2 is one of the key regulators of the transcriptional programs, it maintains stem cell properties and guides cell lineage specification. It is a multiprotein complex formed by a core and ...
