Universitat Pompeu Fabra
Mostrando ítems 2121-2140 de 3292
The term "neurodegenerative disorder" refers to a set of illnesses in which the neurological system gradually deteriorates and is characterized by cognitive impairment, motor degradation, and behavioural changes. The ...
In this Thesis we have studied how dynamics and space modulate cellular behaviour, by means of mathematical modelling of particular biological examples. At the single cell level, we show how pulsatile input signals can be ...
L’Splicing de les molècules d’ARN és el procés pel qual les seqüències interposades (“introns”) s’eliminen, i les seqüències restants es concatenen per a formar l’ARN madur. La investigació recent mostra que gairebé ...
L'aparició de la pluricel·lularitat (MC) va definir un esdeveniment evolutiu important en la història de la vida al nostre planeta. Ha tingut lloc diverses vegades dins de grups independents i diferents enfocaments han ...
This work explores the multidimensional, ambiguous and temporal characteristics of tonality. The approach relies on interfacing pitch-spaces with time vs. time-scale descriptions. In this combined representation, the spatial ...
La disponibilidad de herramientas conceptuales para la descripción y la extracción en un determinado dominio de conocimiento es fundamental para garantizar el acceso a la información. En contextos de conflictos armados ...
Existen diferentes modelos para la provisión de servicios de atención al parto y distintos factores relacionados con la organización de los servicios en los que se atiende a las mujeres. En esta tesis se exploran los ...
La tesis Modelos experimentales de enseñanza y aprendizaje del chino como lengua extranjera a través de tareas y planteamientos competenciales se inicia con una reflexión teórica sobre las condiciones de aplicación al caso ...
Alterations in the expression of carbohydrates and the enzymes involved in their synthesis (glycosidases and glycosyltransferases) can be considered as universal feature of malignant transformation. Iminosugars, monosaccharide ...
L'adenocarcinoma ductal de pàncrees és un càncer molt agressiu que actualment representa la quarta causa de mort per càncer als països occidentals. Les teràpies clàssiques, basades en la resecció quirúrgica, la radioteràpia ...
Aggregation of the amyloid-β (Aβ) peptide to form oligomers and amyloid fibrils is a central event in the pathogenesis of Alzheimer’s disease (AD). This thesis aims to provide a better understanding of Aβ toxicity and the ...
Auricular transcutaneous vagus nerve stimulation (atVNS) is an evolving non-invasive neuromodulation technology, which is under investigation for therapeutic applications, including cognitive improvement. In this thesis, ...
Genome wide association studies (GWAS) have pointed out ORMDL3 gene as a risk factor for several proinflammatory and autoimmune diseases. The protein encoded by this gene belongs to a family of transmembrane proteins of ...
This thesis introduces SIMPLE (Structured Illumination based Point Lo- calization Estimator), a novel super-resolution technique in fluorescence microscopy. By combining standing-wave patterned illumination with single-molecule ...
Cachexia and muscle deconditioning, which are the major comorbidities in patients with chronic diseases including lung cancer (LC), impair disease prognosis. Several biological mechanisms are involved in these two muscle ...
In the present thesis we studied the effects of hydric stress in the ovary of the cockroach Blattella germanica. At morphological level, we described ovarian resorption induced by water deprivation. At a molecular level, ...
In contrast to mammals, zebrafish do have the ability to regenerate their heart after injury. A better understanding of how regenerationcompetent species do so should help developing strategies to enhance human cardiac ...
En los últimos años hemos sido testigos de la identificación de múltiples familias de receptores inmunológicos. En este contexto encontramos la recientemente descrita familia IREM/CD300 localizada en la región cromosómica ...
Unlike characteristic HP1 proteins, the HP1c isoform of Drosophila melanogaster is a euchromatic protein. HP1c forms a complex with the zinc finger proteins ROW and WOC, which are crucial for HP1c function. In the present ...
DNA hypomethylation of repeats has been found in almost every tumor type studied. Hypomethylation of repetitive elements was shown to increase the likelihood of homologous recombination of these repeated sequences and thus ...
