Now showing items 1614-1633 of 3254

    Integrative study of the regulatory and epigenomic programs involved in cancer development 

    Jené i Sanz, Alba (Date of defense: 2013-04-29)

    El càncer ha estat tradicionalment considerat una malaltia fonamentalment genètica, però recentment s'està fent palès que la desregulació de mecanismes epigenètics contribueix en gran manera al desenvolupament tumoral. ...

    Integrative understanding of transcription in a minimal cell model 

    Lloréns Rico, Verónica (Date of defense: 2016-09-15)

    One of the major challenges of biology is to understand how entire cells or organisms behave in homeostasis and in response to perturbations. Whole-cell modeling promotes this understanding by integrating different cellular ...

    Inter-individual physiological variation in the nematode Caenorhabditis elegans 

    Perez, Marcos Francisco (Date of defense: 2018-01-30)

    For unknown reasons, genetically identical animals often differ substantially in their phenotypic traits, even in a controlled environment. Here I investigate the causes of inter-individual physiological variation using a ...

    Inter-individual variability and temporal scaling in the aging transcriptome 

    Martin, Olivier M. F. (Date of defense: 2022-04-05)

    Gràcies als amplis esforços d'investigació, la nostra comprensió dels mecanismes fisiològics de l'envelliment ha progressat enormement. Recentment, les tecnologies òmiques han permès l'estudi a tot el genoma dels canvis ...

    Interacció farmacològica entre la 3.4-Metilendioximetamfetamina (MDMA, Èxtasi) i la paroxetina en humans 

    Segura Agulló, Mireia (Date of defense: 2004-07-09)

    La 3,4-metilendioximetamfetamina (MDMA, èxtasi) és una droga de síntesi que es consumeix entre els joves de forma recreativa. S'ha postulat que la 3,4-dihidroximetamfetamina (HHMA), metabòlit que es forma a partir de ...

    Interaction and participation in collaborative storytelling systems 

    Colás Álvarez, Joaquim (Date of defense: 2017-09-20)

    Storytelling is one of the oldest models of cultural expression in human history. Thanks to the evolution of information technologies, the Web 2.0 paradigm has impacted in this field: some modern audiences actively participate ...

    Interactive language learning in deep network agents 

    Dessí, Roberto (Date of defense: 2024-04-12)

    Recent advances in language modeling led to remarkable performance in many NLP applications. However, the static and passive learning imposed by the nexttoken- prediction objective makes models suboptimal when deployed in ...

    Intercambio de información policial y protección de datos personales en Europa: ADN forense en la investigación criminal 

    Domènech Ganau, Jordi (Date of defense: 2022-06-13)

    El intercambio de información entre los distintos cuerpos policiales favorece la cooperación entre Estados cuando se trata de luchar contra el crimen, pero a veces puede afectar al derecho a la protección de datos de ...

    Intercultural relations and family-school trust: immigrant and native families in schools of Barcelona 

    Mina, Prokic (Date of defense: 2020-01-23)

    The main aim of the thesis is to explain intercultural relations between immigrant and native families in the school context and how these reflect in their trust in local schools. For this purpose, I analyze the relationship ...

    Internal logistics optimization in the automotive industry 

    Fabri Lima, Marcelus (Date of defense: 2020-01-27)

    This thesis focus on internal logistics flows (ILF), which is defined as the flows of materials inside the same business or the same plant. Precisely, this work approaches the ILF of SEAT, a company in the Volkswagen ...

    International and Domestic Trade since 1980: Growth and Crises. 

    Zymek, Robert (Date of defense: 2011-07-20)

    This thesis sheds light on several macroeconomic aspects of international and domestic goods trade during the last three decades. The first chapter investigates the causes of the growth of world trade during this period ...

    International animal law: the case of farm animal welfare 

    Prasličková, Aurélia (Date of defense: 2022-07-19)

    Animal welfare has emerged as a pervasive concern in modern international law. Although the question of animal welfare is one of the greatest social justice issues of our times, there is a surprising lack of legal ...

    International juridical double taxation and individuals' ability to pay in the light of EU law 

    Mendonça, Maria Júlia Ildefonso (Date of defense: 2023-02-23)

    According to the CJEU’s case law, the tax disadvantage suffered by taxpayers in a cross-border situation arising from international juridical double taxation does not constitute a forbidden obstacle to free movement because ...

    The International legal regime of submarine cables: a global public interest regime 

    Shvets, Daria (Date of defense: 2021-03-25)

    This thesis, entitled The International Legal Regime Of Submarine Cables: A Global Public Interest Regime, aims to analyze the legal regime governing submarine cables, identify its deficiencies and examine how they might ...

    Internet i patrimoni cultural: el cas de les col•leccions d'instruments musicals en línia 

    Torrents, Llum (Date of defense: 2016-01-22)

    Aquesta tesi s'ha desenvolupat entorn les repercussions i oportunitats creades per la digitalització, accessibilitat en línia al patrimoni cultural i la preservació digital, doncs el llenguatge hipermèdia i els nous fluxos ...

    INTEROCC : Occupational exposure assessment for electromagnetic fields and risk of brain tumours. Development of a new source-based approach 

    Vila Rodríguez, Javier (Date of defense: 2016-11-25)

    Introducción: Con el fin de mejorar los métodos de evaluación de la exposición a campos electromagnéticos, desarrollamos un nuevo método basado en fuentes de exposición en lugar de códigos de ocupación. Mediciones obtenidas ...

    Interoperabilidad de metadatos en sistemas distribuidos 

    Peig Olivé, Enric (Date of defense: 2004-02-09)

    Usar metadatos para referenciar, etiquetar y describir recursos es cada vez más usual. Esto permite establecer mejores mecanismos para descubrir y localizar material publicado en repositorios públicos accesibles por la ...

    Interplay between cancer cells, fibroblasts, immune cells, and resistance to PD-1/PD-L1 inhibition in breast cancer 

    Soria Jiménez, Luis (Date of defense: 2023-02-17)

    Although the dual anti-HER2 blockade with trastuzumab and pertuzumab monoclonal antibodies has improved the outcome of patients with HER2+ breast cancer, a significant number of patients relapse. Additional strategies for ...

    Interplay of human adaptative NKG2C+ NK cells with specific antibodies and T cells in the response to cytomegalovirus infection 

    Costa García, Marcel (Date of defense: 2018-06-11)

    Human cytomegalovirus (HCMV) infection induces persistent changes in the host immune system, namely a sustained expansion of effector memory and cytotoxic specific T lymphocytes, the production of antibodies (Ab) and, in ...

    Interpretable deep-learning models for sound event detection and classification 

    Zinemanas Frieti, Pablo (Date of defense: 2023-10-20)

    Deep-learning models have revolutionized state-of-the-art technologies in many research areas, but their black-box structure makes it difficult to understand their inner workings and the rationale behind their predictions. ...