Universitat Pompeu Fabra
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El envejecimiento implica un aumento de la fragilidad en función del tiempo que resulta en la aceleración de la mortalidad. Para comprender el papel temporal de varias proteínas en el envejecimiento, utilizamos el sistema ...
La transició Epiteli-Mesènquima es dóna durant el desenvolupament embrionari i en els estadis tardans de la progressió tumoral permetent que es produeixi la metàstasi. Aquestes transicions necessiten una repressió de ...
Els factors de transcripció de la família Snail són fonamentals en la "transició epiteli-mesènquima", procés morfogènic essencial en el desenvolupament embrionari i en els fenòmens metastàsics tumorals.<br/>En els mamífers ...
Els trastorns de la conducta alimentària (TCA) tenen una etiologia complexa en la que hi intervenen factors de predisposició socioculturals, ambientals i genètics. S'ha aprofundit en les bases moleculars dels TCA mitjançant ...
The outer epithelial layer is the first cell type that emerges during development, providing essential mechanical protection and is indispensable for morphogenesis. Here, we study how the interplay between molecular and ...
Cells commonly live in a crowded environment, in a tissue or in a developing embryo. The extracellular matrix and/or surrounding neighboring cells can impose physical deformations to which cells need to adapt in order to ...
Desde Darwin y Lamarck, a los biólogos les ha intrigado la posibilidad de que rasgos adquiridos debido al ambiente pudieran ser heredados. Se han descrito muchos ejemplos de este tipo debidos a perturbaciones del ambiente ...
During mitosis, spindle assembly involves different sources of microtubules including centrosomes and chromosomes. While the role of centrosomes has been extensively studied, we still do not fully understand how chromosomes ...
The mechanisms of pre-mRNA splicing regulation are poorly understood. Here we dissect how the Saccharomyces cerevisiae ribosomal L30 protein blocks splicing of its pre-mRNA upon binding a kink-turn structure including the ...
Chronic respiratory diseases, especially chronic obstructive pulmonary disease (COPD), and several molecular mechanisms may predispose to lung cancer (LC) development. Hypothesis: We hypothesized that different biological ...
Targeted therapies against the Epidermal Growth Factor Receptor (EGFR) are useful to treat many human cancers such as non-small cell lung cancer, colorectal cancer and head and neck cancer. However, the efficacy of such ...
Actualment, degut a la disponibilitat d’un gran nombre de genomes seqüenciats, el camp de la genòmica comparativa està experimentant grans avenços. Ara són possibles una àmplia gama d’estudis que fins fa poc eren inimaginables. ...
La caquexia afecta negativamente a los pacientes con enfermedades crónicas y sobre todo en el cáncer. Las estrategias terapéuticas son aún limitadas. Los beta2-agonistas (formoterol) y el soporte nutricional (L-carnitina) ...
The mechanisms by which amyloid beta (Aβ) causes synaptic dysfunction in Alzheimer’s disease (AD) remain elusive. Aβ is derived by sequential cleavage of the amyloid precursor protein (APP) and released from neurons, but ...
Animals perceive the external world through their sensory systems, which consists in: i) sensory receptors that detect external stimuli; ii) neuronal pathways that convey the sensory information to the brain; and iii) ...
Brain activity during rest exhibits a robust intrinsic spatio-temporal structure characterized by correlated patterns of neural activity. The study of the brain in altered states of vigilance or drug-induced brain states ...
This doctoral thesis presents two different computational approaches to explore mechanistically chondrocyte dysregulation and identify biomarkers, to better understand patient stratification systems in primary knee ...
This thesis analyses the processes undergone by mainstream media during the independence debate in Catalonia, focusing on the relationship among media, their audiences and governments through different empirical perspectives. ...
Esta tesis doctoral estudia la circulación de las traducciones literarias en formato libro entre Bulgaria y el mundo hispánico (España e Hispanoamérica) durante el periodo situado entre 1882 y 2012. La investigación se ...
Tobacco consumption is the leading cause of preventable cancer mortality worldwide and it is the origin of cardiovascular and respiratory diseases. Tobacco specific nitrosamines (TSNAs) are classified as type I carcinogens ...
