Universitat Pompeu Fabra
Now showing items 1629-1648 of 3213
Cellular senescence has mainly been associated with tumor suppression and aging, mediated through cell intrinsic cell-cycle inhibition and arrest. However, through secretion of specific proteins, termed the senescence-associated ...
The aim of this thesis is to delve into sperm RNA dynamics during maturation and paternal inheritance. To obtain an integrative multi-omics view of sperm RNA during these processes, I turned to the new direct RNA sequencing ...
Genetically tractable model organisms may help to identify new approaches to stop malignant growth. During the first part of my doctoral thesis, I have participated in a high content screen carried out to this end taking ...
Embryonic stem cells (ESCs) are derived from the inner cell mass of the pre-implantation embryo and can recapitulate early developmental stages of the embryo. ESCs have the ability to continuously propagate while maintaining ...
Mouse embryonic stem cells (ESCs) require extracellular signals to induce the expression of intrinsic core pluripotency factors: Oct4, Sox2 and Nanog, known as the OSN triad. Notably, the Wnt/β-catenin pathway has been ...
The adaptive response of cells to external stimuli is an intriguing mechanism at the basis of the existence of life itself. For this purpose, signalling pathways and gene regulatory networks elegantly evolved translating ...
Cellular senescence is an irreversible form of proliferative arrest, historically linked to tumour suppression and aging. Recent discoveries, however, have extended its known role to include complex biological processes ...
Investigation of protein-ligand interactions has been a long-standing application for molecular dynamics (MD) simulations given its importance to drug design. However, relevant timescales for biomolecular motions are orders ...
This thesis studies how firms’ investment and credit are affected by different financial imperfections related to firm and bank learning, relationship lending and financial wealth. After reviewing in chapter 2 the related ...
El tabaquismo es la principal causa de muerte evitable en todo el mundo, responsable de más de 7 millones de muertes al año. La nicotina es el principal componente psicoactivo del tabaco y la responsable de sus propiedades ...
Chronic pain is a major clinical problem producing huge economic and social burdens. Currently, chronic pain treatment has limited efficacy and significant side effects. One of the reasons of this unmet clinical need is ...
The increase incidence of obesity and eating disorders represents a major health problem in developed countries. The low rate of success of treatments to prevent or reverse obesity, and overeating that causes it, highlights ...
Hypocretin-1 and hypocretin-2, also known as orexin-A and orexin-B, are 2 neuropeptides that are exclusively expressed by a small subset of neurons of the lateral hypothalamic area. Despite their restricted expression ...
Food addiction is closely associated with eating disorders including obesity and binge eating. However, the neural alterations underlying this disorder have not been yet clarified. We have trained mice in an operant model ...
The generation of urban digital elevation models from satellite images using stereo reconstruction techniques poses several challenges due to its precision requirements. In this thesis we study three problems related ...
The thesis shows the result of the research on foreign policy during the first and second Abe administration. It focuses on the relations with the US, China, India, Australia, the Philippines, the New Komei Party and ...
El objeto de estudio de esta tesis es la interacción que se produce en las audiencias de solicitud de asilo en Bélgica y los textos escritos que se generan en el procedimiento, principalmente, informes de audiencia y ...
Joan Fuster és una de les personalitats que més han contribuït a la cultura catalana contemporània des del País Valencià. La traducció va ser una de les nombroses activitats literàries i culturals que va realitzar. Això ...
Aquesta tesi proposa un recorregut per la Girona del segle XVII a través dels seus plets, negociacions polítiques i controvèrsies en general. Ens acompanyen en el trajecte els dirigents del municipi, naturalment, i també ...
The starting point of this research is a transnational vision of the avant-garde production of Joan Pérez-Jorba (Barcelona, 1878 − Paris, 1928), which includes both his journalism and poetry, from a receptive and creative ...
