Ara mostrant els elements 21-30 de 52
Mestre Farràs, Neus (Data de defensa: 2021-09-16)
La tesi doctoral aquí presentada busca entendre quin és el paper de les proteïnes d’unió a l’ARN en la progressió tumoral, ja que s’ha demostrat que aquestes proteïnes poden regular aspectes que permeten ...
Severino, Jacqueline (Data de defensa: 2021-03-30)
X chromosome reactivation in female mouse germ cells is essential for the transmission of one active X chromosome to the progeny. However, despite its key role in development, the mechanistic details and ...
Mantica, Federica (Data de defensa: 2023-05-11)
Regulated Gene Expression (rGE) and Alternative Splicing (rAS) are two of the main mechanisms contributing to tissue-phenotypic diversity within and between species. In this thesis, we aim at characterizing ...
Pich Roselló, Oriol (Data de defensa: 2021-03-24)
Cells of our body are constantly exposed to events that can create lesions in the DNA. If unremoved by the DNA repair mechanisms, the lesion may lead to a mutational event. Some of these events might ...
Cabrerizo Granados, David (Data de defensa: 2020-11-30)
Snail1 is a transcriptional factor with a great relevance in tumor development as it is required for epithelial to mesenchymal transition and activation of cancer-associated fibroblasts (CAF). In this ...
Sebastián Perez, Rubén (Data de defensa: 2021-09-10)
Chromocenters are established after the 2-cell (2C) stage during mouse embryonic development, but the factors that mediate chromocenter formation remain largely unknown. To identify regulators of 2C ...
Tu, Xiaochuan (Data de defensa: 2023-07-27)
Embryonic stem cells (ESCs) are derived from the inner cell mass of the pre-implantation embryo and can recapitulate early developmental stages of the embryo. ESCs have the ability to continuously ...
Dan, Yuzhen (Data de defensa: 2022-02-24)
p38α (encoded by MAPK14) is a major regulator of cellular responses to almost all types of environmental and intracellular stresses. Upon activation, p38α phosphorylates various substrates both in the ...
Anlas, Kerim (Data de defensa: 2022-07-06)
Across metazoans, minimal in vitro systems from embryonic stem cells (ESCs) recapitulate the establishment of a body plan, particularly the anteroposterior (AP) axis. In contrast to actual embryos that ...
Carrillo García, Julia (Data de defensa: 2021-09-30)
This project has aimed to investigate the regulation of the mechanosensitive ion channel Piezo1 by proteins that sense and modify membrane curvature. Our second objective has been to study this interplay ...