Domínguez Rodríguez, Diana (Date of defense: 2021-05-04)
La metàstasis és responsable del 90% de les morts per càncer, demostrant l’existent manca de coneixement en relació als seus mecanismes moleculars. Investigacions anteriors del nostre laboratori han ...
Vineethakumari Muraleedharan, Chithran (Date of defense: 2024-03-14)
Microtubules form diverse arrays according to the cell type or the cell cycle stage to facilitate the context-specific functions of the cytoskeleton. One way by which cells achieve this is by restricting ...
Ivancic, Dimitrie (Date of defense: 2024-04-03)
Methods for genome engineering have enabled construction of synthetic genomes, therapeutically reprogrammed cells, synthetic organs, and modification of human genomes. Design and discovery of genome ...
Özer, Ege Ekin (Date of defense: 2024-03-21)
In this thesis, we explored neural entrainment as a potential mechanism to underline the behavioral evidence that certain phonological properties of listeners’ native language affects speech segmentation. ...
Bajew, Simon (Date of defense: 2022-04-12)
Alternative splicing is a post-transcriptional process that allows the generation of multiple transcript and protein isoforms from a single gene by differential processing of exons and introns. This ...
Shekari, Mahnaz (Date of defense: 2024-04-03)
This thesis explores technical factors influencing brain PET quantification, developing brain PET harmonization framework, assessing Centiloid robustness as a clinical biomarker, and evaluating the ...
Sondermann, Nathalie Allegra Faye (Date of defense: 2024-03-21)
Polycomb repressive complexes (PRC1/2) are key chromatin regulators in development. Their deregulation is implicated in various cancers including leukaemia. Meanwhile, MLL-rearrangements by chromosomal ...
Delgado Tejedor, Anna (Date of defense: 2024-03-21)
RNA modifications, collectively known as the ‘epitranscriptome’, play a major role in multiple biological processes, including splicing regulation, gene expression regulation and antibiotic resistance. ...
Morales Pastor, Adrián (Date of defense: 2024-04-11)
G protein-coupled receptors (GPCRs) are central to cellular signaling and pivotal in drug development. This thesis investigates allosteric communication in GPCRs, crucial for their effective modulation ...
Suárez Ara, Patricia (Date of defense: 2024-04-12)
The origin of animals has puzzled scientists for centuries. The transition from a unicellular eukaryote to animals is undoubtedly one of the biggest evolutionary transitions in Earth’s history. To unravel ...