Gallego Jiménez, Alicia (Date of defense: 2016-11-14)
microRNAs are small non-coding RNAs with crucial roles in gene regulation and whose contribution to animal evolution has been largely demonstrated. In this thesis we explored some functional consequences ...
Di Giovanni, Francesca (Date of defense: 2016-11-24)
Chromatin is not randomly organized inside the eukaryotic nucleus in interphase. In budding yeast gene expression of some specific loci is affected by their positioning in the nucleus. Replication ...
Burga Ramos, Alejandro Raúl (Date of defense: 2012-07-20)
Genetically identical cells and organisms growing in homogenous environmental conditions can show significant phenotypic variation. Furthermore, mutations often have consequences that vary among individuals ...
Palacios Verdú, María Gabriela (Date of defense: 2015-10-19)
Williams-Beuren syndrome is a neurocognitive disorder with multisystemic manifestations of variable expressivity caused by a 1.55-1.83 Mb at chromosomal band 7q11.23. In this thesis project we have ...
Gelabert Xirinachs, Pere (Date of defense: 2018-12-14)
La malària és una malaltia infecciosa causada per diverses espècies de protozous del gènere Plasmodium, capaces d’infectar eritròcits humans. La malària és probablement la patologia infecciosa que ha ...
Hoermann, Astrid (Date of defense: 2014-11-14)
Esta tesis revela la regulación transcripcional del gen gap giant (gt) en el embrión blastodermal de Drosophila por ingeniería inversa: un modelo matemático infiere los mecanismos subyacentes de datos ...
Rein, Katrin (Date of defense: 2015-03-23)
The maintenance of genome stability is crucial for homeostasis, development and suppression of diverse pathologies that include developmental disorders, premature aging and cancer. The DNA damage response ...
Bello, Carla (Date of defense: 2017-12-15)
La identificación de elementos funcionales en el genoma no-codificante continúa siendo una tarea desafiante. La genómica comparativa puede ayudarnos a entender como estos elementos han evolucionado y ...
Söylemez, Onuralp (Date of defense: 2015-10-09)
The role of epistasis – inter-dependent contributions of alleles to fitness – in shaping genetic variation within and between populations is an important question in evolutionary biology with significant ...
Pant, Devesh Chandra (Date of defense: 2018-10-05)
In spite of recent advances in understanding the genetic bases of leukodystrophies, a large number of clinical cases remain unexplained, suggesting that many leukodystrophy-associated genes have yet to ...