Garrido Martín, Diego (Date of defense: 2020-01-30)
We have developed an efficient and reproducible pipeline for the identification of genetic variants affecting splicing (splicing quantitative trait loci or sQTLs), based on an approach that captures the ...
Esteller Cucala, Paula (Date of defense: 2023-04-18)
Changes in the epigenetic regulation of gene expression have important implications for evolution. However, the study of these changes (i) has not been consistently assessed across closely related ...
Fontseré Alemany, Clàudia (Date of defense: 2020-12-17)
Wild chimpanzee populations are considered to be under threat of extinction due to the damaging consequences of human impact into their natural habitat and illegal trade. Conservation genomics is an ...
Ferrando-Bernal, Manuel (Date of defense: 2021-07-09)
The aim of this thesis is to apply Identity by Descent (IBD) methodology to identify ancestry connections among individuals from genetically similar populations. Recombination events diminish the ...
Hernandez Alias, Xavier (Date of defense: 2023-02-23)
Malgrat teixits diferents presenten diferències en l'ús de codons i en els repertoris d'anticodons dels ARNt, el coneixement sobre la co-adaptació entre codó-anticodó en eucariotes multicel·lulars és ...
Renom, Pere (Date of defense: 2023-02-22)
According to estimates, over the 3.5 billion years that have elapsed since the appearance of life, the Earth has been inhabited by some 4 billion different species, of which 99.99% have already become ...
Lucas, Morghan C. (Date of defense: 2023-04-24)
The aim of this thesis is to delve into sperm RNA dynamics during maturation and paternal inheritance. To obtain an integrative multi-omics view of sperm RNA during these processes, I turned to the new ...
Zadra, Ivan (Date of defense: 2022-03-17)
To ensure faithful segregation of the genetic material, cells build the mitotic spindle, a machinery made of dynamic microtubules (MTs) and MT associated proteins (MAPs). Chromosome bi-orientation is ...
Gamarra Figueroa, Gianni Paolo (Date of defense: 2024-01-26)
Acute myeloid leukemias (AMLs) are a type of cancer where undifferentiated myeloid cells abnormally proliferate. Such phenotype can be caused by the expression of chimeric proteins like PML-RARα and ...
González i Colell, Marc (Date of defense: 2024-02-23)
Engineering biology requires a clear set of rules that ensure design predictability. However, certain biological processes difficult the application of these rules, impairing prediction. In the first ...