Pohl, Andy (Date of defense: 2014-10-03)
Genome-wide analysis of the nucleosome positioning and histone H1 isoform content of the T47D breast cancer cell line has found a number of observations, namely that with a gentle digestion of microccocal ...
Villanueva Cañas, José Luis (Date of defense: 2015-11-20)
Although the genome sequencing revolution is still in its infancy, we must acknowledge it as the major driver of biology since the beginning of the 21st century. The availability of a large collection ...
Cerutti, Andrea (Date of defense: 2013-07-19)
Immunoglobulin (Ig) diversification is essential for the generation of protective immune responses against intruding microbes. B cells require cognate interaction with T cells to generate protective ...
Noriega Esteban, Núria (Date of defense: 2009-02-27)
La adaptación de la levadura Saccharomyces cerevisiae a condiciones de alta osmolaridad está mediada por la vía de HOG ((high-osmolarity glycerol). La activación de esta vía induce una serie de respuestas ...
Serra Vidal, Gerard (Date of defense: 2018-12-05)
Àfrica és l'origen de totes les poblacions humanes actuals, i malgrat contenir els nivells més elevats de diversitat genètica, la seva història demogràfica ha estat relativament poc estudiada, amb moltes ...
Han, Sojung (Date of defense: 2019-10-16)
Bonobos are an interesting species to study due to their unique evolutionary features such as a peaceful social nature and hypersexual behavior. The prolonged exaggerated sexual swelling in females ...
Serrano Candelas, Eva (Date of defense: 2012-12-20)
The protein phosphatase calcineurin (Cn), together with its substrates, the transcription factors NFATc, play an essential role in several physiological processes of vertebrates, such as the immune ...
Sampietro Bergua, Mª Lourdes (Date of defense: 2007-01-19)
In this thesis we have addressed three different although related topics. First, we studied the post-mortem mutation damage rate of contaminated DNA sequences in ancient human remains focusing on the ...
Dobón Berenguer, Begoña (Date of defense: 2018-11-23)
The evolution of the genome is driven, among other factors, by the composition of the genome, the functional output of the gene products, and by environmental pressures. Among the environmental factors, ...
Kuderna, Lukas (Date of defense: 2020-01-24)
Genomic analyses are at the center of contemporary biology. These studies heavily rely on reference genome assemblies, yet those are typically highly fragmented. Having accurate representations of complex ...