Rodríguez Botigué, Laura (Date of defense: 2012-11-16)
The history of North Africa is extremely complex, and it has been difficult to assess from genetic and archeological data whether early populations were replaced by later migrations or if there has ...
Torruella Loran, Ignasi (Date of defense: 2016-10-28)
Els microRNAs són importants reguladors de gens i destacats contribuïdors a la diversitat fenotípica clarament involucrats en malaltia humana. Hem analitzat la variabilitat genètica en microRNAs i como ...
Dols Icardo, Oriol (Date of defense: 2016-12-15)
There are overwhelming evidences that amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are part of a clinical, pathological and genetic continuum. The C9orf72 repeat expansion is ...
Domingo Espinós, Júlia (Date of defense: 2020-02-21)
The first aim of this thesis was to tackle a core question in biology—to understand how large numbers of mutations combine together to influence phenotypes. In order to do so, we built a combinatorial ...
Invergo, Brandon M. (Date of defense: 2013-11-22)
Phototransduction is the biochemical process by which a light stimulus is converted to a neuronal signal. The process functions through complex interactions between many proteins, which work in concert ...
Telford, Marco (Date of defense: 2017-12-19)
This thesis focuses on Human herpesvirus 4 and 6, two ubiquitous viruses with a long list of putative disease associations, ranging from malignancies such as lymphomas and carcinomas to multiple sclerosis. ...
Eliscovich, Carolina (Date of defense: 2008-06-11)
La progresión meiótica y el desarrollo embrionario temprano están programados, en parte, por la activación tradcuccional de mRNAs maternos como lo son los que codifican para las proteinas de ciclina B1 ...
Aigner, Johanna (Date of defense: 2013-11-25)
La família B7 de proteïnes és àmpliament reconeguda per jugar un paper important en els processos inflamatoris mitjançant l'alteració de la capacitat de resposta de les cèl•lules T. La unió d’aquestes ...
Herranz Martín, Nicolás (Date of defense: 2011-09-23)
The epithelial to mesenchymal transition (EMT) is a highly conserved cellular program that allows well-‐differentiated epithelial cells to convert to motile mesenchymal cells. ...
Hernández Rodríguez, Jéssica (Date of defense: 2018-06-08)
The innovation of genomics has progressed at pace with the development of high-throughput DNA sequencing technologies. Prior to the outbreak of next-generation sequencing, retrieving genetic information ...