Villegas Mirón, Pablo (Date of defense: 2021-07-19)
The evolutionary history of the human genome has been shaped by the selection of multiple elements in response to different environmental pressures. The analysis of regulatory adaptations and the ...
Mariotti, Marco (Date of defense: 2013-12-13)
Selenoproteins are a diverse class of proteins containing selenocysteine, the 21st aminoacid. Selenocysteine is inserted co-translationally, recoding very specific UGA codons through a dedicated ...
Segura Puimedon, Maria (Date of defense: 2012-11-20)
Williams-Beuren syndrome (WBS) is a neurodevelopmental disorder caused by the common deletion of 26-28 contiguous genes in the 7q11.23 region, which poses difficulties to the establishment of ...
Solé Morata, Neus (Date of defense: 2017-12-15)
The Y chromosome is the longest non-recombining DNA sequence of the human genome. This avoidance of recombination, together with its paternal inheritance, makes the Y chromosome a powerful tool with ...
Álvarez Errico, Damiana (Date of defense: 2006-07-13)
El presente trabajo describe el clonaje y caracterización de un nuevo receptor inhibidor de la superfamilia de las Ig, que hemos denominado IREM-1 (Immune Receptor Expressed by Myeloid Cells). El analisis ...
Althammer, Sonja Daniela (Date of defense: 2012-04-27)
The recent advent of High-Throughput Sequencing (HTS) methods has triggered a revolution in gene regulation studies. Demand has never been higher to process the immense amount of emerging data to gain ...
Ferrández Peral, Luis (Date of defense: 2022-06-08)
The evolution of transcriptomes has been linked to the emergence of novel phenotypes. However, our knowledge on how isoform diversity has impacted recent human evolution is very limited. To fill this ...
Bou de Pieri, Francesc (Date of defense: 2020-12-17)
Tot i que l’obesitat és clarament deguda a un desequilibri entre la ingesta d’energia i la despesa, i està molt associada a l’estil de vida, es considera una malaltia multifactorial amb una alta ...
Gigli, Elena (Date of defense: 2011-06-20)
The evolutionary history of H. neanderthalensis, interwoven with that of H. sapiens, has always fascinated the scientific world. Recent adavncess in paleogenetics shedds new light on the phylogenetic ...
Rodríguez Galindo, Miguel (Date of defense: 2023-11-13)
Tumor progression is dominated by two evolutionary forces: first mutagenesis, which provides the heritable variability where, secondly, natural selection acts. The main challenge of cancer genomics is ...