Mostrando ítems 11-20 de 30
Sala Romanyà, Laura (Fecha de defensa: 2018-06-20)
Snail1 is a transcription factor which activity is required for the fibroblasts-to-myofibroblast differentiation. In the first part of the thesis we characterize a protein complex involving Snail1, PRMT1 ...
Rubio Pérez, Carlota (Fecha de defensa: 2017-11-28)
Cancer is a disease of the genome. The study of tumor genomic alterations is used to guide several precision medicine strategies, some approved and a large number under clinical development. On the other ...
Pich Roselló, Oriol (Fecha de defensa: 2021-03-24)
Cells of our body are constantly exposed to events that can create lesions in the DNA. If unremoved by the DNA repair mechanisms, the lesion may lead to a mutational event. Some of these events might ...
Vali Pour Jamnani, Mischan (Fecha de defensa: 2022-06-02)
Somatic mutations are an inevitable component of ageing and the most important cause of cancer. The rates and types of somatic mutation vary across individuals, but relatively few inherited influences ...
Güney, Emre (Fecha de defensa: 2012-09-25)
The cell is governed by the complex interactions among various types of biomolecules. Coupled with environmental factors, variations in DNA can cause alterations in normal gene function and lead to a ...
Pavlovic, Milica (Fecha de defensa: 2014-03-11)
El objetivo de esta tesis era identificar determinantes genéticos de cáncer de mama con metástasis óseas. Para ello se utilizó un enfoque integral que se sustenta en células humanas de cáncer de mama, ...
Núñez Ollé, Marc (Fecha de defensa: 2014-07-04)
Cyclin O, a novel identified CDK1 and CDK2-binding cyclin, has been demonstrated to be required for γ-radiation induced apoptosis in a lymphoid cell line. Ɣ-radiation induces the formation of DSBs in ...
Bassaganyas Bars, Laia (Fecha de defensa: 2013-09-20)
Over the last ten years, improvements in molecular techniques and the arrival of the next-generation sequencing technologies have revealed a large amount of structural variation (SV) in the human genome. ...
Heredia Genestar, José María (Fecha de defensa: 2020-01-28)
La mutació és un procés essencial per l’evolució, tot i que també té un rol important tant en el càncer com en altres malalties. Les mutacions no s’acumulen uniformement al llarg del genoma i la seva ...
Alba Castellón, Lorena (Fecha de defensa: 2016-02-17)
Snail transcription factor 1 triggers epithelial to mesenchymal transition. In cancer, this process provides tumoral epithelial cells with invasive characteristics. In this thesis, we demonstrated that ...
616 - Patología. Medicina clínica. Oncología (11)
575 - Genética general. Citogenética general. Inmunogenética. Evolución. Filogenia (8)
576 - Biología celular y subcelular. Citología (4)
577 - Bioquímica. Biología molecular. Biofísica (2)
615 - Farmacología. Terapéutica. Toxicología. Radiología (2)