Anlas, Kerim (Date of defense: 2022-07-06)
Across metazoans, minimal in vitro systems from embryonic stem cells (ESCs) recapitulate the establishment of a body plan, particularly the anteroposterior (AP) axis. In contrast to actual embryos that ...
Lloréns Rico, Verónica (Date of defense: 2016-09-15)
One of the major challenges of biology is to understand how entire cells or organisms behave in homeostasis and in response to perturbations. Whole-cell modeling promotes this understanding by integrating ...
Aragüés Peleato, Ramón (Date of defense: 2007-07-13)
La importancia de comprender los procesos biológicos ha estimulado el desarrollo de métodos para la detección de interacciones proteína-proteína. Esta tesis presenta PIANA (Protein Interactions And ...
Vendrell Arasa, Alexandre (Date of defense: 2009-01-16)
L'activació sostinguda de Hog1 porta a una inhibició del creixement cel·lular. En aquest treball, hem observat que el fenotip de letalitat causat per l'activació sostinguda de Hog1 és parcialment inhibida ...
Rubbini, Davide (Date of defense: 2016-04-29)
Hair cell damage, caused by various insults, results in hearing loss in humans, one of the major health problems nowadays. In mammals damaged hair cells cannot regenerate, whereas lower vertebrates have ...
Carrillo García, Julia (Date of defense: 2021-09-30)
This project has aimed to investigate the regulation of the mechanosensitive ion channel Piezo1 by proteins that sense and modify membrane curvature. Our second objective has been to study this interplay ...
Sleep Ronquillo, Eduard (Date of defense: 2010-06-30)
In contrast to mammals, zebrafish do have the ability to regenerate their heart after injury. A better understanding of how regenerationcompetent species do so should help developing strategies to enhance ...
Martín Rodríguez, Elena (Date of defense: 2018-01-24)
A splicing network analysis that captured functional similarities among spliceosomal components, revealed a prominent core module containing splicing factors SPF45, SR140 and CHERP. We report that ...
Ritschka, Birgit (Date of defense: 2017-09-15)
Cellular senescence has mainly been associated with tumor suppression and aging, mediated through cell intrinsic cell-cycle inhibition and arrest. However, through secretion of specific proteins, termed ...
Ollé Vila, Aina (Date of defense: 2020-02-12)
Les grans transicions evolutives han transformat profundament la manera com la informació s'organitza i es transmet, a vegades en la forma d'un nou nivell jeràrquic que conté entitats que prèviament es ...