Krüger, Angela (Date of defense: 2012-12-14)
The embryo of Caenorhabditis elegans is a model system in which development can be studied at single cell resolution. In this thesis I describe the use of a semi-automatic nuclear tracking algorithm to ...
Kłosin, Adam (Date of defense: 2015-11-09)
Desde Darwin y Lamarck, a los biólogos les ha intrigado la posibilidad de que rasgos adquiridos debido al ambiente pudieran ser heredados. Se han descrito muchos ejemplos de este tipo debidos a ...
Vali Pour Jamnani, Mischan (Date of defense: 2022-06-02)
Somatic mutations are an inevitable component of ageing and the most important cause of cancer. The rates and types of somatic mutation vary across individuals, but relatively few inherited influences ...
Reis, Kadri (Date of defense: 2016-03-23)
Una gran proporción del genoma de la mayoría de eucariotas superiores está formado por secuencias repetitivas de DNA que contienen señales de represión de la transcripción. Para entender mejor cómo ...
Perez, Marcos Francisco (Date of defense: 2018-01-30)
For unknown reasons, genetically identical animals often differ substantially in their phenotypic traits, even in a controlled environment. Here I investigate the causes of inter-individual physiological ...
Toufighi, Kiana (Date of defense: 2014-10-31)
Over the last several decades, the emerging ‘integrated’ view of the cell has triumphed over the ‘one gene/one protein/one function’ paradigm. This is illustrated by the biologically opposite effects ...
Domingo Espinós, Júlia (Date of defense: 2020-02-21)
The first aim of this thesis was to tackle a core question in biology—to understand how large numbers of mutations combine together to influence phenotypes. In order to do so, we built a combinatorial ...
Burga Ramos, Alejandro Raúl (Date of defense: 2012-07-20)
Genetically identical cells and organisms growing in homogenous environmental conditions can show significant phenotypic variation. Furthermore, mutations often have consequences that vary among individuals ...
Baeza Centurión, Pablo (Date of defense: 2020-02-27)
Alternative pre-mRNA splicing is a regulated step in eukaryotic gene expression in which introns are removed from the transcript and exons are joined together to form a mature mRNA. To study the effects ...