Selfa Aspiroz, Idoia Lucía (Date of defense: 2022-02-01)
During the last years, the development of procedures to direct the differentiation of human pluripotent stem cells (hPSCs) towards different renal cell types has resulted in the establishment of approaches ...
Mestres Gonzalvo, Enric (Date of defense: 2022-02-18)
The embryo culture system is composed by all those elements with the potential to impact embryo development. Its optimization is required to stabilize in vitro embryo culture and produce reliable and ...
Sinigaglia, Barbara (Date of defense: 2022-11-25)
Several rainforest hunter-gatherer groups in south-east Asia are characterized by specific morphological features including a particularly dark skin color (D), an extremely short stature (S), the ...
Martínez Ara, Guillermo (Date of defense: 2022-09-19)
During embryonic development, cellular forces synchronize in space and time to generate functional tissue shapes. Apical constriction is a force-generating process necessary to provoke the folding of ...
Häkkinen, Hanna-Maria (Date of defense: 2022-07-01)
Cellular errors can spontaneously occur during vertebrate embryo development and can lead to apoptosis. Recent work in our lab revealed a novel function of the embryonic epithelium as an efficient ...
Pezzano, Fabio (Date of defense: 2022-06-13)
Cells commonly live in a crowded environment, in a tissue or in a developing embryo. The extracellular matrix and/or surrounding neighboring cells can impose physical deformations to which cells need ...
Belmonte Mateos, Carla (Date of defense: 2022-02-03)
Precise regulation of neurogenesis is achieved by differentially allocating the neurogenic competence along the tissue. In the hindbrain proneural gene expression is stereotypically confined in segment ...
Kozyczkowska, Aleksandra (Date of defense: 2022-03-11)
To address one of the most fascinating questions in the history of life, the origin of animal multicellularity, we needed experimentally tractable representatives from each of the unicellular lineages, ...
Dan, Yuzhen (Date of defense: 2022-02-24)
p38α (encoded by MAPK14) is a major regulator of cellular responses to almost all types of environmental and intracellular stresses. Upon activation, p38α phosphorylates various substrates both in the ...
Anlas, Kerim (Date of defense: 2022-07-06)
Across metazoans, minimal in vitro systems from embryonic stem cells (ESCs) recapitulate the establishment of a body plan, particularly the anteroposterior (AP) axis. In contrast to actual embryos that ...