Universitat Pompeu Fabra: Recent submissions
Now showing items 441-460 of 3276
Creating the AML-specific t(9;11) chromosomal translocation model to study the structural basis of leukemia development in mouse cells
Chromosomal translocation are large-scale genome rearrangements found in several cancers. They are formed when two (or more) non-homologous chromosomes interchange large parts as a result of erroneous DNA repair after ...
Evolution of the transcriptomic regulation in the primate lineage
The evolution of transcriptomes has been linked to the emergence of novel phenotypes. However, our knowledge on how isoform diversity has impacted recent human evolution is very limited. To fill this gap, we have performed ...
Motivación e intervención delictiva: una revisión de la "participación psíquica"
La presente tesis doctoral efectúa una aproximación a la motivación al delito desde una perspectiva dogmática. El objetivo es doble. Por un lado, establecer una base de incriminación materialmente legítima para este fenómeno. ...
Immunotherapy of chronic virus infections : Exhausted CD8+ T cell subsets are differentially regulated by XCR1 + DC
The contribution of cross-presenting XCR1+ dendritic cells (DC) in maintaining T cell function during exhaustion and immuno-therapeutic interventions of chronic infections remains poorly characterized. Using the mouse model ...
The Role of chromatin-associated factors in genome topology
Gene expression, epigenetic states and topological conformation are three fundamental aspects of genome organization that are tightly regulated in space and time. Epigenetic states, protein occupancy and chromatin ...
The Impact of germline variants on human somatic mutation processes
Somatic mutations are an inevitable component of ageing and the most important cause of cancer. The rates and types of somatic mutation vary across individuals, but relatively few inherited influences on mutation processes ...
El Anglicismo terminológico: consecuencias léxicas del uso de textos escritos en inglés en las clases de medicina en español
This PhD dissertation deals with the analysis of the linguistic characteristics of terminological anglicisms in relation to the use of written texts in English as a means of preparation for oral and written communication ...
Cross-modal multilingualism: a reflection on language emergence via Pattern Asociation
Cross-modal and intra-modal language transfer divergences were analysed along with developmental ones from the multilingual texts written by 13 deaf sign-multilingual teenage learners whose L1 and language of instruction ...
Study of molecular targets and neurobiologial mechanisms involved in compulsive overeating
Binge-eating disorder (BED) is a chronic eating disturbance that affects 1.6-2.0% of people worldwide. It is characterised by recurrent episodes of consuming large amounts of food in a short period, together with a sense ...
Interpretable machine learning through radiomics and attribute-regularized neural networks for cardiology
El diagnóstico asistido por ordenador de enfermedades cardiovasculares (CVD) con resonancia magnética cardíaca (CMR) es un campo importante de investigación para el fenotipado avanzado de imágenes cardíacas. Las mediciones ...
Essays on the economic psychology of well-being
This thesis consists of three chapters that improve our knowledge of how income shapes well-being. Chapter 1 (“Measuring Affect Dynamics: An Empirical Framework”) presents an empirically-derived framework to conduct ...
A physician-in-the-loop approach by means of machine learning for the diagnosis of lymphocytosis in the clinical laboratory
The complete blood count (CBC) is one of the most commonly performed test due to its clinical utility, versatility and safety. Thus, there are well established consensus rules to review a CBC through the peripheral blood ...
A 3D culture system to study gene regulation in breast cancer cells
In this Thesis we report the successful growth of hormone responsive T47D cells as 3D spheroids in Matrigel mimicking the ECM. A detailed characterization by using a genome-wide approach of the main physical and biochemical ...
The Developing architecture of expressive pragmatics in preschoolers: multimodal and structural language trumps social cognition
Pragmatics, defined as the ability to use language socially, matters enormously in our day-to-day life and involves both the linguistic and social aspects of human communication. The literature focusing on developmental ...
The Structural and functional organization of the language network in non- or minimally verbal autism spectrum disorders
Language impairment forms a broader spectrum in humans than current diagnostic labels such as specific language impairment suggest. This thesis is about language capacities at the neglected bottom end of severity across ...
Efectividad de las estrategias de comunicación en la entrevista laboral: estudio perceptivo y psicofisiológico del impacto de las estrategias comunicativas basadas en sesgos cognitivos en la selección de personal
El presente estudio parte de una premisa relacionada tanto con intereses investigadores como con una voluntad de aplicación práctica. Tras la identificación de un vacío en la literatura científica referido a la investigación ...
Diseño, aplicación y evaluación de un programa CLIL y EPI de Música en inglés, en el ciclo superior de Educación Primaria
Esta investigación tiene como objeto de estudio la elaboración, aplicación y evaluación de un programa de mejora del nivel de inglés a partir de una propuesta CLIL en Música, desde un enfoque plurilingüe integrador de ...
Comparative cellular biology of vetebrate primordial oocytes
En este proyecto, hemos desarrollado métodos que permiten la caracterización comparativa basada en imágenes en vivo de ovocitos primordiales de humano, ratón y Xenopus. Mostramos que los ovocitos primordiales en las tres ...
Differential genetic events in the two main pathways of prostate carcinogenesis : Molecular, pathological and clinical analysis of crucial genetic alterations in ETS fusion-positive and negative prostate cancer
S'han identificat dues vies carcinogèniques en el càncer de pròstata (CaPr): la positiva i la negativa per a fusions dels gens ETS. L’objectiu d’aquest estudi ha estat entendre el significat biològic i la posició jeràrquica ...
Learning to identify and encode entities with deep learning models
In this thesis, I tackle the ability of deep neural networks to represent entities, and I assess the extent to which this feature impacts tasks involving entities. I consider two standard architectures, LSTM and Transformer, ...
