Universitat Pompeu Fabra: Recent submissions
Now showing items 461-480 of 3276
A deep learning perspective on linguistic ambiguity
This thesis studies the information that an expression and its context contribute to ambiguity resolution, focusing on the syntactic, lexical, and referential levels, and on the English language. I adopt computational ...
A machine learning approach to computer modeling of musical expression for performance learning and practice
Aquesta tesi tracta sobre el disseny i la implementació de sistemes informàtics per a l'execució musical expressiva (CSEMP), explorant diferents mètodes de l'aprenentatge automàtic i reflexionant sobre el paper de l'estructura ...
Characterization of fluid biomarker profiles in the preclinical stage of the Alzehimer's continuum
La malaltia d’Alzheimer (MA) està precedida per una llarga etapa preclínica, en la qual es desenvolupa la patologia cerebral en absència de simptomatologia. La identificació acurada d’aquesta fase preclínica, i un millor ...
Illuminating the chemical space of therapeutical relevance : from pharmaceutical patents to untargeted proteins
Systems pharmacology is the discipline that studies the so-called ‘pharmacological space’ with a holistic and network-based perspective. Its challenge is to shed light on the astonishingly sophisticated biological processes ...
Unraveling luminal breast cancer heterogeneity
Metastasis is the major cause of death from Breast Cancer (BCa). During its progression, divergent opinions have arisen regarding the hormonal status of the BCa subtypes. The mammary gland is composed of different cell ...
Inter-individual variability and temporal scaling in the aging transcriptome
Gràcies als amplis esforços d'investigació, la nostra comprensió dels mecanismes fisiològics de l'envelliment ha progressat enormement. Recentment, les tecnologies òmiques han permès l'estudi a tot el genoma dels canvis ...
SRRM3 regulates a subprogram of highly sensitive microexons important for pancreatic endocrine function
Alternative splicing is a post-transcriptional process that allows the generation of multiple transcript and protein isoforms from a single gene by differential processing of exons and introns. This Thesis focuses on ...
Unravelling the roles of an alternatively spliced microexon in Daam1 in nervous system development and function
Microexons are an unusual form of alternative splicing with high evolutionary conservation, however, their functions are still far from being understood. In this thesis, we focused on a neuronal-specific microexon that ...
Una Aproximación a los efectos en salud y calidad de vida de un programa de regeneración urbana en Chile
The general objective of this thesis was to evaluate the effects of the Chilean urban regeneration program "Quiero mi Barrio" on the health and quality of life of people living in Chile, taking into account socioeconomic ...
Integrative proteomic analysis of ovarian cancer : understanding tumour physioloy and predicting response to treatment
High-grade serous carcinoma (HGSC) is the most common and deadly subtype of ovarian cancer. It is characterised by presenting defects in the homologous recombination repair, most frequently associated to BRCA1 mutations. ...
Statistical modelling of the baby face for 3D Face Reconstruction
In this thesis, we address the problem of reconstructing the 3D facial geometry of babies from uncalibrated 2D images. This topic has many different applications, but it is especially relevant for the early diagnosis of ...
Causes and consequences of affective polarisation in comparative perspective
This PhD dissertation adds to the literature that studies affective polarisation in comparative perspective. Citizens of democracies around the globe express substantive levels of hostility towards opposing parties, their ...
How new technologies change politics
This dissertation investigates how new technologies such as social media, digitalizing workplaces, and robotization change society and politics. The first chapter focuses on new technologies affecting the democratic ...
Information representation and processing in neuronal networks: from biological to artificial systems and from first to second-order statistics
Neuronal networks are today hypothesized to the basis for the computing capabilities of biological nervous systems. In the same manner, artificial neuronal systems are intensively exploited for a diversity of industrial ...
Construction of injectable wireless microstimulators based on rectification of volume conducted high frequency currents
Functional neuromuscular stimulation (FNS) refers to the delivery of electrical stimuli to nerves or muscles to enhance, modify or restore motor functions. Despite their invasiveness, implantable systems for FNS offer ...
Precarious employment and mental health in Europe : Development, validation, and association with mental health of a novel cross-national measure
This dissertation aims to advance knowledge on the contours of precarious employment (PE) as a social determinant of health by developing, validating, and evaluating the association with mental health of a novel measure ...
Variations of Polycomb assembly in mouse embryonic stem cells and early differentiation
Polycomb repressive complex (PRC)1 and 2 are major players in gene regulation, devoted to maintenance of the epigenetic memory of gene silencing. Mouse embryonic stem cells (mESCs) have been extensively exploited as a model ...
Large-scale online learning under partial feedback
La toma secuencial de decisiones con incertidumbre cubre una amplia clase de problemas. Las aplicaciones reales requieren que los algoritmos sean computacionalmente eficientes y escalables. Nosotros estudiamos un rango ...
Data-driven pitch content description of choral singing recordings
Ensemble singing is a well-established practice across cultures, found in a great diversity of forms, languages, and levels. However, it has not been widely studied in the field of Music Information Retrieval (MIR), ...
Feminist initiatives supporting self-managed abortion in legally restrictive settings of Latin America and the Caribbean : Social inequalities and quality of care
In this thesis our aim was to understand social inequalities and quality of care in feminist initiatives supporting self-managed abortion in legally restrictive settings of Latin America and the Caribbean. The thesis ...
