Avaluació de la utilitat del monitoratge farmacocinètic dels fàrmacs anti-TNF en pacients amb malaltia inflamatòria intestinal en dos hospitals amb diferent grau d’especialització 

    Vila Currius, Mireia (Date of defense: 2020-03-09)

    The tumor necrosis factor (TNF) acts as a potent inducer of inflammation in autoimmune diseases like Crohn disease and ulcerative colitis. Current available treatments are based on TNF inhibition such as infliximab and ...

    Bypass gástrico en el tratamiento de la obesidad mórbida. Seguimiento a 5 años de los primeros 300 casos en la provincia de Girona 

    Rodríguez Hermosa, José Ignacio (Date of defense: 2018-12-10)

    A prospective study on 300 morbidly obese patients who underwent gastric bypass in the province of Girona with a follow-up of 5 years.More female (288/12), mean age 43.5 years, mean weight 118.7 kg, mean BMI 46.1 kg/m2. ...

    Cognitive function in obesity: interactions with the gut microbiome 

    Arnoriaga Rodríguez, María (Date of defense: 2022-04-27)

    Obesity is considered a modifiable risk factor for cognitive impairment which, in turn, predisposes to overeating and weight gain. Compelling evidence in animal models has demonstrated the impact of the gut microbiome on ...

    Control and modeling techniques in biomedical engineering: the artificial pancreas for patients with type 1 diabetes 

    Abu-Rmileh, Amjad Hisham Ahmad (Date of defense: 2013-12-09)

    This thesis presents different control strategies, for the closed-loop artificial pancreas, which are based on Model Predictive Control (MPC) and Sliding Mode Control (SMC). Multiple MPC with linear models and gain scheduling, ...

    Dehiscencia de anastomosis en la cirugía del cáncer de recto: incidencia, factores pronósticos y morbimortalidad asociada 

    Farrés Coll, Ramon (Date of defense: 2023-03-10)

    Introduction: Anastomotic leak (AL) is the most feared complication in the postoperative period for patients with rectal cancer. Objectives: To determine the real rate of AL in patients operated on for rectal cancer. ...

    Descripció i quantificació de la microbiota intestinal associada al càncer colorectal 

    Mas de Xaxars Rivero, Teresa (Date of defense: 2012-10-02)

    Colorectal Cancer is the main type of cancer in Spain. Up to 90% of the cases are sporadic in nature and its aetiology is still unclear. It is supposed to be a multi-factorial disease, where factors play an important role ...

    Detecció de la Ribonucleasa 1 anòmalament glicosilada en sèrums humans: possible ús com a marcador tumoral del càncer de pàncreas 

    Barrabés Vera, Sílvia (Date of defense: 2007-10-08)

    L'adenocarcinoma pancreàtic és una neoplàsia amb mal pronòstic per la que no existeixen marcadors específics. En aquesta tesi s'han estudiat possibles alteracions de les estructures glucídiques de la ribonucleasa pancreàtica ...

    Development of new, non-invasive tools based on faecal bacterial signatures for the early detection of colorectal cancer 

    Malagón Rodríguez, Marta (Date of defense: 2019-12-13)

    This thesis aims to develop a new non-invasive tool based on faecal bacterial markers for the early detection of colorectal cancer, which is capable of detecting precancerous lesions before the onset of clinical signs. ...

    Ecophysiology and philogeny of Faecalibacterium prausnitzii in healthy and diseased gut. Application in Inflamatory Bowel Disease diagnostics 

    López Siles, Mireia (Date of defense: 2016-01-25)

    In this PhD thesis Faecalibacterium prausnitzii populations of patients with gut disease and healthy individuals have been characterized. First, isolates from healthy volunteers have been phenotypically characterised, ...

    Factors pronòstics en la dehiscència anastomòtica de la cirurgia del càncer de còlon. Models de predicció actuals i validació externa independent 

    Pigem Rodeja, Anna (Date of defense: 2023-03-03)

    INTRODUCTION: Anastomotic leak (AL) is the most dreadful and life-threatening complication in colon cancer (CC) surgery. It is associated to an increase of morbimortality, longer hospital stay, increased healthcare costs ...

    Genetics and transcriptomics of adherent-invasive Escherichia coli (AIEC): new approaches to uncover molecular markers for its rapid identification 

    Camprubí Font, Carla (Date of defense: 2019-07-26)

    The adherent-invasive Escherichia coli (AIEC) pathotype could play a role in the course of Crohn’s disease. This is characterized by its capacity to adhere to and to invade intestinal epithelial cells as well as to replicate ...

    Intestinal microbiology in Crohn's disease: a study of Escherichia coli as a potential etiologic agent 

    Martínez Medina, Margarita (Date of defense: 2009-12-22)

    La malaltia de Crohn és una malaltia inflamatòria intestinal crònica d'etiologia encara desconeguda. Actualment es pensa que hi participen factors genètics i immunològics que confereixen una susceptibilitat a l'hoste, i ...

    La infermeria d'atenció primària en l'atenció als problemes del peu en la diabetis tipus 2 a Catalunya 

    Jurado Campos, Jerónimo (Date of defense: 2009-06-12)

    Aquesta tesi pretén respondre a la pregunta: Què pot fer la infermeria d'atenció primària i què és el què fa, en els problemes del peu en persones amb diabetis tipus 2 a Catalunya?. L'estat del tema exposa la importància ...

    Monitoratge de la malaltia inflamatòria intestinal en la pràctica clínica mitjançant marcadors de la microbiota intestinal en mostres fecals. Estudi prospectiu 

    Miquel Cusachs, Josep Oriol (Date of defense: 2021-12-17)

    The gut microbiota (GM) plays a pivotal role in the maintenance of gut homeostasis, and the pathogenesis of inflammatory bowel disease (IBD) which includes Crohn's disease (CD) and ulcerative colitis (UC). The degree of ...

    New tumour markers for pancreatic cancer based on the altered glycosylation of serum glycoproteins 

    Duran Sidera, Adrià (Date of defense: 2023-11-14)

    Pancreatic cancer (PaC) is the deadliest of all tumours, with a 5-year survival below 12% and a mortality/incidence ratio of 94.5%. One of the main reasons behind this dismal prognosis is the diagnosis of the disease at ...

    Relevance of the epigenetic regulation exercised by hepatic microRNAs in the fatty liver arena: from the bedside to the bench 

    Latorre Luque, Jèssica (Date of defense: 2020-03-04)

    Non-alcoholic fatty liver disease (NAFLD) has become the leading cause of chronic liver disease worldwide, involving a spectrum of disturbances mainly characterized by fatty acid infiltration and fat deposition in the liver ...

    Signatures bacterianes com a eines de diagnòstic diferencial i monitoratge de les malalties inflamatòries intestinals 

    Amoedo Cibeira, Joan (Date of defense: 2020-12-15)

    Inflammatory Bowel Disease (IBD) is a group of immune-based pathologies that affect the digestive tract, causing chronic inflammatory diseases processes. In recent years, the microbial communities that inhabit the human ...